Premature ovarian insufficiency and infertility

Magraith, Karen; Fernando, Waduge Dhanushi; Vincent, Amanda

doi:10.31128/ajgp-08-22-6531

Cited by 4 publications

(1 citation statement)

References 29 publications

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“…premature ovarian insufficiency —menopause occurring before 40 years of age; women may experience oligomenorrhoea and amenorrhoea during this time 2 …”

Section: Introductionmentioning

confidence: 99%

Management of menopause

Magraith,

Jang

2023

Aust Prescr

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SUMMARY During perimenopause and after menopause, women may experience diverse symptoms. All women require a comprehensive assessment of their current health and risks for future disease, appropriate screening, and promotion of a healthy lifestyle. Menopausal hormone therapy is the most effective treatment for menopausal symptoms. It can be offered to symptomatic patients with no contraindications following an individualised discussion about the risk of harms versus benefits. Menopausal hormone therapy is recommended for women with premature ovarian insufficiency (menopause occurring before 40 years of age) regardless of symptoms, unless contraindicated. Nonhormonal medications may improve symptoms for women who have contraindications to, or do not wish to take, menopausal hormone therapy.

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“…premature ovarian insufficiency —menopause occurring before 40 years of age; women may experience oligomenorrhoea and amenorrhoea during this time 2 …”

Section: Introductionmentioning

confidence: 99%

Management of menopause

Magraith,

Jang

2023

Aust Prescr

Self Cite

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The role of mitochondrial DNA copy number in female infertility: a bidirectional two-sample Mendelian randomization study

Wan,

Lai,

Huang

et al. 2024

Gynecological Endocrinology

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An improved method for experimental modeling of premature ovarian insufficiency in Wistar rats

Zakurayeva,

Yarmolinskaya,

Adamenkov

et al. 2023

Journal of obstetrics and women's diseases

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BACKGROUND: Despite an enormous progress in the field of reproductive endocrinology, the mechanisms of premature ovarian insufficiency have not been fully understood so far. Knowledge of the supposed causes and mechanisms underlying the development of premature ovarian insufficiency has expanded significantly in recent years, mainly due to advances in genetics and the creation of models for experimental research. The experimental modeling of premature ovarian insufficiency, which is as close as possible to the origin and development of the corresponding disease in humans, is effectively used to elaborate promising therapeutic approaches, in particular, to test new drugs or biologically active agents in order to study their preventive or curative effects. This article discusses the main methods of the experimental modeling of POI in laboratory animals. We have herein summarized the literature data related to the development of the clinical and morphological picture of the disease, with the advantages and disadvantages of each of the models analyzed. AIM: The aim of this study was to modify the premature ovarian insufficiency modeling methodology to substantiate the effectiveness and to test new directions in drug therapy with subsequent implementation in clinical practice. MATERIALS AND METHODS: The new method is based on the creation of an experimental premature ovarian insufficiency model in female Wistar rats. To obtain this model, experimental rats were randomized into two groups: 1) animals receiving cyclophosphamide at a dose of 150 mg/kg b.w. subcutaneously once (n = 10); 2) animals receiving 2 ml of saline intraperitoneally once (n = 9). On day10, the animals were removed from the experiment. After autopsy, a visual assessment of morphological changes in the ovaries was carried out, and a right-sided ovariectomy was performed. RESULTS: When using the proposed model, the reproducibility rate of POI has reached 100%. CONCLUSIONS: Our modification of the method ensures the creation of a highly reproducible premature ovarian insufficiency model in Wistar rats. Another significant advantage of this modeling method is its ease of implementation and economic efficiency.

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Premature ovarian insufficiency and infertility

Cited by 4 publications

References 29 publications

Management of menopause

Management of menopause

The role of mitochondrial DNA copy number in female infertility: a bidirectional two-sample Mendelian randomization study

An improved method for experimental modeling of premature ovarian insufficiency in Wistar rats

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