Premature ovarian insufficiency secondary to COVID‐19 infection: An original case report

Wilkins, James A.; Al-Inizi, Shamma

doi:10.1002/ijgo.13719

Cited by 24 publications

(26 citation statements)

References 4 publications

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“…ACE2 is widely expressed in the female reproductive system including the ovary, uterus, vagina, and placenta so that follicle development and ovulation, luteal angiogenesis and degeneration as well as regular changes in endometrial tissue and embryo development may be influenced by COVID-19. 94 Considering the disturbance of female reproductive functions, 95 following-up and evaluation of fertility are recommended in patients with a menstrual disorder or those with a delay in pregnancy. Menstrual data analysis of women of childbearing age diagnosed with COVID-19 revealed that a menstrual volume decrease or cycle prolongation in one-fifth of patients as a consequence of transient sex hormone changes.…”

Section: Covid-19 and Gynecologymentioning

confidence: 99%

The overall impact of COVID‐19 on healthcare during the pandemic: A multidisciplinary point of view

Sabetkish

Rahmani

2021

Health Science Reports

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Background and Aims The Coronavirus disease 2019 (COVID‐19) pandemic globally changed the priorities of medical and surgical procedures. It has caused many healthcare systems to stop performing their routine screenings. Altering medical clinics to COVID‐19 referral centers, lockdowns, and the public fear to refer to medical centers caused a significant reduction in the referral rate; especially in the elderly. This short review article highlights the transform in clinical practice during the post‐COVID era and the need for future medical revolutions. Methods A comprehensive literature search was separately performed by both authors. The articles published between 2019 and August 2021 were included in this study and selected according to a quality appraisal method. Results We have summarized the possible corresponding changes in the diagnosis and treatment of all fields of medical care including internal medicine, surgical, and minor subcategories after the COVID‐19 pandemic. We have also discussed the potential impacts of the pandemic on all these different categories and subcategories of medicine, including the outpatient setting and clinical work. We do believe that the lack of routine check‐ups has led to an increase in the stage of disease in patients with a previously diagnosed problem. On the other hand, the dramatic change in the lifestyle of the population including restricted mobility and increased consumption of unhealthy food has caused metabolic syndrome and other new diseases that have not been diagnosed and properly managed. Conclusion Our findings revealed the urgent need for public health awareness. It indicated the need to carry out both psychological and screening approaches in the post‐COVID era to not miss patients with a chronic disease and new cases who were undiagnosed during the COVID pandemic.

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Section: Covid-19 and Gynecologymentioning

confidence: 99%

The overall impact of COVID‐19 on healthcare during the pandemic: A multidisciplinary point of view

Sabetkish

Rahmani

2021

Health Science Reports

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“…Although the patients were women between 42-54 years of age, and that COVID-19 can elicit premature ovarian insufficiency, 11,12 no significant clinical or analytical signs suggestive of menopause were detected in any of the participants. Even if night sweats had been due to perimenopausal symptoms, they vanished after increasing their carbohydrate intake at night.…”

Section: Discussionmentioning

confidence: 89%

Impact of evening carbohydrate intake on the resolution of persistent night sweats in patients with long COVID: a case series

2022

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Up to 25% of patients with long COVID experience persistent night sweats. However, in most cases they remain untreated until they disappear on their own. Since SARS-CoV-2 is known to disrupt glucose homeostasis, we hypothesized that impaired mitochondria would result in faster glycogen depletion at night due to reduced ATP production yield, inducing adrenaline production ultimately leading to the onset of persistent night sweats. To test our hypothesis we investigated whether incorporating carbohydrates into the diet of three non-diabetic patients with long COVID before bedtime would have any effect decreasing their night sweats. Remarkably, after one week with the dietary intervention, the patients reported that their night sweats had completely disappeared. Therefore, we propose carbohydrate supplementation as an affordable solution for night sweats in long COVID patients.

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“…AOAs can be detected in 24-73% of patients with POI and may appear years before POI diagnosis [41,44]. Moreover, there are some reports of POI developing after viral infections, including one case report of COVID-19-related POI and AOA formation after anti-HPV vaccination [45,46].…”

Section: Pathogenesis Of Poimentioning

confidence: 99%

The Role of Noncoding RNA in the Pathophysiology and Treatment of Premature Ovarian Insufficiency

Pankiewicz¹,

Laudański

Issat³

2021

IJMS

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Premature ovarian insufficiency (POI) is defined as a loss of ovarian function before the age of 40 years, with a prevalence rate estimated at approximately 1%. It causes infertility and is related to serious long-term health consequences, including reduced life expectancy, increased cardiovascular risk, decreased bone mineral density and neurological disorders. There is currently no effective therapy for POI that is widely available in clinical practice; therefore, the treatment of patients with POI is based on hormone replacement therapy. One of the recent advances in the understanding of the pathophysiology of POI has been the role of microRNAs (miRNAs) and other noncoding RNAs (ncRNAs) in the disease. Moreover, intensive research on human folliculogenesis and reproductive biology has led to the development of novel promising therapeutic strategies with the use of exosomal miRNAs derived from mesenchymal stem cells to restore ovarian function in POI patients. This narrative review focuses on the new studies concerning the role of ncRNAs in the pathogenesis of POI, together with their potential as biomarkers of the disease and targets for therapy.

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Premature ovarian insufficiency secondary to COVID‐19 infection: An original case report

Abstract: Synopsis This is a case of premature ovarian insufficiency, likely induced by COVID‐19. The association has not been reported to date.

Cited by 24 publications

References 4 publications

The overall impact of COVID‐19 on healthcare during the pandemic: A multidisciplinary point of view

The overall impact of COVID‐19 on healthcare during the pandemic: A multidisciplinary point of view

Impact of evening carbohydrate intake on the resolution of persistent night sweats in patients with long COVID: a case series

The Role of Noncoding RNA in the Pathophysiology and Treatment of Premature Ovarian Insufficiency

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