Premature progesterone rise on day of hCG negatively correlated with live birth rate in IVF cycles: An analysis of 1022 cycles

Lepage, Jean-Yves; Keromnes, Gwenola; Epelboin, Sylvie; Luton, Dominique; Yazbeck, Chadi

doi:10.1016/j.jogoh.2018.05.005

Cited by 12 publications

(8 citation statements)

References 18 publications

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“…E2 and P during ovarian stimulation are likely to in uence clinical outcomes in ART treatment. Elevated P on hCG day negatively in uences clinical pregnancy and live birth, and is associated with an increased rate of miscarriage (Lepage et al, 2019, Li et al, 2008). An increase in the serum P level on hCG day is associated with premature luteinization, following an undesired early rise in LH during the follicular phase of the nal oocyte maturation (Fleming and Jenkins, 2010).…”

Section: Discussionmentioning

confidence: 99%

Factors improved clinical outcomes in patients < 38 years with diminished ovarian reserve and low oocyte retrieval: a retrospective study

Chen

Liu

et al. 2023

Preprint

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Background: In young patients with Diminished ovarian reserve (DOR), the number of retrieved oocytes limits the success of assisted reproductive technology, but which factors influence the clinical outcome of young DOR patients who already have retrieved few eggs is still unclear. Methods: We retrospectively analyzed clinical date of 349 young DOR patients (< 38 years old and FSH >10IU/L) with low oocyte retrieval (≤ 5 oocytes). Results: Total of 18 candidate variables were tested. Seven factors were identified as being significantly different (P < 0.05) between the clinical pregnancy group and the non-clinical pregnancy group. six factors were significantly different between the live-birth group and the non-live birth group. In multivariate analysis, lower antral follicle count (AFC) and estradiol (E2) level on hCG day were independent negative risk factors associated with the outcome of clinical pregnancy, as well as live birth. Lower progesterone (P) on hCG day was associated with a higher rate of clinical pregnancy and live birth. Conclusions: Our study indicated that AFC, E2 on hCG day, and P on hCG day are prognostic factors for clinical pregnancy and live birth rates in young DOR patients with low oocyte retrieval.

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Section: Discussionmentioning

confidence: 99%

Factors improved clinical outcomes in patients < 38 years with diminished ovarian reserve and low oocyte retrieval: a retrospective study

Chen

Liu

et al. 2023

Preprint

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“…Two retrospective studies investigated the impact of PL on live birth rate and concluded that PL could reduce significantly live birth rate [17,91]. Another retrospective study included 1022 IVF-ICSI cycles reported that PL was associated with both increase in miscarriage rate and decrease in live birth rate, despite equivalent initial implantation and clinical pregnancy rates between the study groups of with and without PL [92]. Surprisingly, PL (P ≥ 2 ng/ml) was linked to low birth weight in fresh embryo transfer cycles, after adjustment of confounding factors like estradiol levels and maternal age [93].…”

Section: Pl and Live Birth Ratementioning

confidence: 99%

Revisiting debates of premature luteinization and its effect on assisted reproductive technology outcome

Hussein

Elnashar

Amin

et al. 2019

J Assist Reprod Genet

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The impact of the prematurely elevated serum progesterone on the late follicular phase, commonly known as premature luteinization (PL), is a matter of continuing debate. Available evidence supports that serum progesterone ≥ 1.5 ng/ml on the day of ovulation triggering could reduce the pregnancy potential in fresh in vitro fertilization (IVF) cycles by jeopardizing endometrial receptivity. Causes of PL during ovarian stimulation are unclear. Recent studies point toward the daily follicle-stimulating hormone dosage, duration of controlled ovarian stimulation, number of oocytes retrieved, and peak estradiol level as factors affecting the incidence of PL. Emerging data show additional influence on embryo quality. The prevention of PL has been challenging. The key elements in preventing PL include individualization of ovarian stimulation according to patient's ovarian reserve, proper ovulation trigger timing, and use of medications such as corticosteroids and metformin. Embryo cryopreservation with deferred embryo transfer is the established strategy to overcome PL, yet it is an extra burden to the IVF laboratory and increased cost for patients. Herein, we review the up-to-date knowledge of this frequent IVF problem including causes, proposed diagnostic criteria, and its impact on endometrial receptivity, embryo quality, and pregnancy outcomes. The preventive measures and rescue strategies are also discussed.

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“…A recent study suggested that elevated P level on the day of HCG administration negatively in uence live birth rate and correlates with high rates of miscarriage. However, the detrimental impact of high P levels during pregnancy does not appear to be associated with endometrial receptivity [2]. A different study indicated that low P levels (≤ 0.5 ng/ml) on the day of HCG administration are associated with low LBR [3].…”

Section: Introductionmentioning

confidence: 96%

Progesterone levels predict pregnancy outcome in individuals with fallopian tube associated infertility

Zhang

2020

Preprint

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Background: To investigate the predictive value of human chorionic gonadotropin(HCG) and progesterone(P) levels on pregnancy outcomes in patients receiving in vitro fertilization(IVF) due to simple fallopian tube factors. METHODS:We retrospectively analyzed the clinical data of 854 cycles from the simple fallopian tube factor IVF fresh embryo transfer.The clinical data of 854 cycles from January 2010 to December 2018 was divided into 7 groups according to the P level on HCG day.Live birth rates(LBR) and observe trends were calculated. The receiver operating characteristic(ROC) curve was established to determine the optimal cutoff value for P, which was used to further divide the data into 3 groups: Group 1 (P ≦ 1.0 ng/ml), Group 2 (1.0 ng/ml ≤ P ≤ 1.25 ng/ml), and Group 3 (P≥1.25ng/ml). We then compared the ovulation results and clinical outcomes between the 3 groups. RESULTS There were no significant differences in age, infertility years, Gonadotropin(Gn)dosage, Gn days, Luteinizing hormone(LH) level on HCG day, 2pronuclear(2PN) fertilization rate, clinical pregnancy rate(CPR), LBR, full-term birth rate, and preterm birth rate among the three groups, but body mass index （BMI）(P = 0.001), basal LH (P = 0.034), estrogen peak (P = 0.000), number of eggs obtained (P = 0.000) were significantly different. CONCLUSION The level of P level on HCG day does not affect the CPR and LBR after IVF. However, P levels between 1.0-1.25ng/ml may lead to good clinical pregnancy outcomes.

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Premature progesterone rise on day of hCG negatively correlated with live birth rate in IVF cycles: An analysis of 1022 cycles

Cited by 12 publications

References 18 publications

Factors improved clinical outcomes in patients < 38 years with diminished ovarian reserve and low oocyte retrieval: a retrospective study

Factors improved clinical outcomes in patients < 38 years with diminished ovarian reserve and low oocyte retrieval: a retrospective study

Revisiting debates of premature luteinization and its effect on assisted reproductive technology outcome

Progesterone levels predict pregnancy outcome in individuals with fallopian tube associated infertility

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Premature progesterone rise on day of hCG negatively correlated with live birth rate in IVF cycles: An analysis of 1022 cycles

Cited by 12 publications

References 18 publications

Factors improved clinical outcomes in patients &lt; 38 years with diminished ovarian reserve and low oocyte retrieval: a retrospective study

Factors improved clinical outcomes in patients &lt; 38 years with diminished ovarian reserve and low oocyte retrieval: a retrospective study

Revisiting debates of premature luteinization and its effect on assisted reproductive technology outcome

Progesterone levels predict pregnancy outcome in individuals with fallopian tube associated infertility

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Product

Resources

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Factors improved clinical outcomes in patients < 38 years with diminished ovarian reserve and low oocyte retrieval: a retrospective study

Factors improved clinical outcomes in patients < 38 years with diminished ovarian reserve and low oocyte retrieval: a retrospective study