Premature skewing of T cell receptor clonality and delayed memory expansion in HIV-exposed infants
Sonwabile Dzanibe,
Aaron J. Wilk,
Susan Canny
et al.
Abstract:While preventing vertical HIV transmission has been very successful, HIV-exposed uninfected infants (iHEU) experience an elevated risk to infections compared to HIV-unexposed and uninfected infants (iHUU). Here we present a longitudinal multimodal analysis of infant immune ontogeny that highlights the impact of HIV/ARV exposure. Using mass cytometry, we show alterations in T cell memory differentiation between iHEU and iHUU being significant from week 15 of life. The altered memory T cell differentiation in iH… Show more
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