2023
DOI: 10.1016/j.isci.2023.106465
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Premature termination of transcription is shaped by Rho and translated uORFS in Mycobacterium tuberculosis

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Cited by 13 publications
(30 citation statements)
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“…The TTS patterns within these two leaders indicated multiple TTS thoughout the metE leader, compared to two, closely spaced TTS in the ppe2 leader, suggesting differences in the regulation of the switches (Fig. 2A & B) (21). To explore how B 12 might affect growth and metE and ppe2 transcription, we grew cultures of M. tuberculosis to OD 600 ~0.6 before adding 10 μg/mL AdoB 12 ; notably, this did not affect the growth rate (Supplementary Fig.…”
Section: Premature Transcription Termination In Mete and Ppe2 Leadersmentioning
confidence: 97%
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“…The TTS patterns within these two leaders indicated multiple TTS thoughout the metE leader, compared to two, closely spaced TTS in the ppe2 leader, suggesting differences in the regulation of the switches (Fig. 2A & B) (21). To explore how B 12 might affect growth and metE and ppe2 transcription, we grew cultures of M. tuberculosis to OD 600 ~0.6 before adding 10 μg/mL AdoB 12 ; notably, this did not affect the growth rate (Supplementary Fig.…”
Section: Premature Transcription Termination In Mete and Ppe2 Leadersmentioning
confidence: 97%
“…We have mapped multiple premature transcription termination sites (TTS) associated with RNA leaders including those of metE and ppe2 in M. tuberculosis cultures grown in standard conditions (21). The TTS patterns within these two leaders indicated multiple TTS thoughout the metE leader, compared to two, closely spaced TTS in the ppe2 leader, suggesting differences in the regulation of the switches (Fig.…”
Section: Premature Transcription Termination In Mete and Ppe2 Leadersmentioning
confidence: 99%
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