Prematurely aging female mice improve their behavioural response, immunity, redox state, and lifespan after a short social interaction with non-prematurely aging mice

Cerro, Estefanía Díaz-Del; Félix, Judith; Fuente, Mónica De la

doi:10.1007/s10522-022-09968-9

Cited by 6 publications

(2 citation statements)

References 64 publications

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“…For mice, we can measure respiration and metabolism used by the metabolic cage and through the respiratory exchange ratio (RER) [ 60 ] to determine the degree of senescence or used by metabolic treadmill in research [ 61 ]. In addition, we can test strength and muscle of mice through small animal handgrip dynamometer [ 62 ] or a wire suspension test [ 63 , 64 ]. For the measurements of bone and fat, we can measure the volume of visceral and subcutaneous fat and analyze the the cortical bone and trabecular bone of the mice by bone imaging [ 61 ].…”

Section: Overview Of Senescencementioning

confidence: 99%

“…For the measurements of bone and fat, we can measure the volume of visceral and subcutaneous fat and analyze the the cortical bone and trabecular bone of the mice by bone imaging [ 61 ]. There are differences in motor, coordination, and endurance between young and senescent mice; thus, it is feasible to judge senescence by track test [ 65 ] and wood rod test [ 64 ]. According to previous studies, mice exhibit higher anxiety like behaviors [ 66 ] with senescence.…”

Section: Overview Of Senescencementioning

confidence: 99%

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Application of mesenchymal stem cells for anti-senescence and clinical challenges

Wang,

Gao,

Wang

2023

Stem Cell Res Ther

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Senescence is a hot topic nowadays, which shows the accumulation of senescent cells and inflammatory factors, leading to the occurrence of various senescence-related diseases. Although some methods have been identified to partly delay senescence, such as strengthening exercise, restricting diet, and some drugs, these only slow down the process of senescence and cannot fundamentally delay or even reverse senescence. Stem cell-based therapy is expected to be a potential effective way to alleviate or cure senescence-related disorders in the coming future. Mesenchymal stromal cells (MSCs) are the most widely used cell type in treating various diseases due to their potentials of self-replication and multidirectional differentiation, paracrine action, and immunoregulatory effects. Some biological characteristics of MSCs can be well targeted at the pathological features of aging. Therefore, MSC-based therapy is also a promising strategy to combat senescence-related diseases. Here we review the recent progresses of MSC-based therapies in the research of age-related diseases and the challenges in clinical application, proving further insight and reference for broad application prospects of MSCs in effectively combating senesce in the future.

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Section: Overview Of Senescencementioning

confidence: 99%

Section: Overview Of Senescencementioning

confidence: 99%

Application of mesenchymal stem cells for anti-senescence and clinical challenges

Wang,

Gao,

Wang

2023

Stem Cell Res Ther

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El tacto, un sentido crucial en las interacciones sociales para mejorar la homeostasis en el envejecimiento y promover una longevidad saludable

Cerro

Félix

Fuente

2023

Revista Española de Geriatría y Gerontología

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Social environment as a modulator of immunosenescence

Garrido

Toda

Cerro

et al. 2022

Expert Rev. Mol. Med.

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Immune system aging, a process known as immunosenescence, involves a striking rearrangement affecting all immune cells, resulting in an increased rate of infections and a major incidence of autoimmune diseases and cancer. Nonetheless, differences in how individuals of the same chronological age carry out this immunosenescence establishment and thus the aging rate have been reported. In the context of neuroimmunoendocrine communication and its role in the response to stress situations, growing evidence suggests that social environments profoundly influence all physiological responses, especially those linked to immunity. Accordingly, negative contexts (loneliness in humans/social isolation in rodents) were associated with immune impairments and decreased lifespan. However, positive social environments have been correlated with adequate immunity and increased lifespan. Therefore, the social context in which an individual lives is proposed as a decisive modulator of the immunosenescence process and, consequently, of the rate of aging. In this review, the most important findings regarding how different social environments (negative and positive) modulate immunosenescence and therefore the aging rate, as well as the role of stress responses, hormesis, and resilience in these environments will be explained. Finally, several possible molecular mechanisms underlying the effects of negative and positive environments on immunosenescence will be suggested.

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Prematurely aging female mice improve their behavioural response, immunity, redox state, and lifespan after a short social interaction with non-prematurely aging mice

Cited by 6 publications

References 64 publications

Application of mesenchymal stem cells for anti-senescence and clinical challenges

Application of mesenchymal stem cells for anti-senescence and clinical challenges

El tacto, un sentido crucial en las interacciones sociales para mejorar la homeostasis en el envejecimiento y promover una longevidad saludable

Social environment as a modulator of immunosenescence

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