Prematurity at less than 24 weeks of gestation is a risk for prolonged hyperglycemia in extremely low-birth weight infants

Yamauchi, Tamio; Imamura, Masatoshi; Takasawa, Kei; Nakajima, Keisuke; Nakagawa, Ryuichi; Gau, Maki; Sugie, Manabu; Taki, Atsuko; Kawai, Masahiko; Kashimada, Kenichi; Morio, Tomohiro

doi:10.1007/s12020-020-02393-3

Cited by 2 publications

(5 citation statements)

References 26 publications

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“…3,11 Most of the hyperglycemia incidents in the neonatal period may develop within the first 14 days of life. 6 However, we excluded hyperglycemia occurring within the first 3 days of life because bacterial infection and death have been reported to be strongly associated with hyperglycemia within this period. 3,6 Thus, we aimed to investigate the cause of hyperglycemia between 3 and 14 days after birth in ELBWIs.…”

Section: Definition Of Outcome Variablesmentioning

confidence: 99%

“…6 However, we excluded hyperglycemia occurring within the first 3 days of life because bacterial infection and death have been reported to be strongly associated with hyperglycemia within this period. 3,6 Thus, we aimed to investigate the cause of hyperglycemia between 3 and 14 days after birth in ELBWIs. We checked the blood glucose levels of the infants at least once every 24 h for the first 5 days of life and at least once every 3 days from day 6 to day 14, depending on the patient's general condition.…”

Section: Definition Of Outcome Variablesmentioning

confidence: 99%

“…The suggested pathological causes of hyperglycemia include continuous glycogenesis irrespective of the serum glucose levels, high serum growth hormone levels, high insulin resistance due to physiological stress and low amount of skeletal muscle, and defective islet beta cell processing of proinsulin. 1,6 Several factors may contribute to the development of hyperglycemia in ELBWIs, including low birth weight and gestational age (GA), administration of catecholamines and glucocorticoids, parenteral nutrition, and stress. 5,7e10 However, numerous diagnostic criteria for hyperglycemia in ELBWIs have been used in literature, making it difficult to describe the epidemiology of hyperglycemia in ELBWIs.…”

Section: Introductionmentioning

confidence: 99%

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Risk factors for hyperglycemia in extremely low birth weight infants during the first 14 days

Inage

Hirano

Nakagawa

et al. 2022

Pediatrics & Neonatology

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Background: There are limited data regarding the risk factors for hyperglycemia in extremely low birth weight infants (ELBWIs). The aim of this observational study was to investigate the incidence of hyperglycemia among ELBWIs during the first 14 days of life and identify independent risk factors for hyperglycemia development. Methods: We retrospectively evaluated 55 ELBWIs (32 male infants) between January 2015 and March 2020. Hyperglycemia was diagnosed when the glucose level was 180 mg/dL. Demographic and clinical data were extracted from the patients' medical records. The risk factors associated with the onset of hyperglycemia were identified by Cox proportional hazards regression analysis with variables that had previously been identified as risk factors for hyperglycemia. Results: Hyperglycemia developed in 23 patients (41.8%) within the first 14 days of life. Gestational age, chorioamnionitis, postnatal intravenous glucocorticoids, and probiotic type were included in the analysis. The results indicated that hyperglycemia was significantly associated with gestational age (hazard ratio [HR], 0.65; 95% confidence interval [CI], 0.48e0.87; P Z 0.004). Further, Bifidobacterium breve (B. breve M-16V) use was related to hyperglycemia in ELBWIs (HR, 2.95; 95% CI, 1.10e7.87; P Z 0.031). Conclusion:Hyperglycemia was strongly associated with lower gestational age and B. breve M-16V use in our study population. Although probiotic supplementation may be beneficial for preterm infants to reduce the incidence of necrotizing enterocolitis, the dextrin used as an excipient in B. breve M-16V may lead to an undesirable carbohydrate load in ELBWIs.

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Section: Definition Of Outcome Variablesmentioning

confidence: 99%

Section: Definition Of Outcome Variablesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Risk factors for hyperglycemia in extremely low birth weight infants during the first 14 days

Inage

Hirano

Nakagawa

et al. 2022

Pediatrics & Neonatology

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“…The incidence of hyperglycemia ranges between 30% and more than 80% [1][2][3][4][5][6]. It is mainly detected in the first two weeks after birth [2,3,7,8]. Threshold values and the duration of hyperglycemia, when insulin treatment is recommended in extremely premature infants, differ from threshold values in infants and infants later in life.…”

Section: Introductionmentioning

confidence: 99%

“…Some studies have shown that an increased glucose infusion rate and higher lipid intake are independent risk factors for hyperglycemia [2,6,10,11,17,18]. Other risk factors include low gestation age, lower birth weight and the need for inotropes, vasopressors and glucocorticoids [2,[4][5][6][7]10,19,20].…”

Section: Introductionmentioning

confidence: 99%

A Higher Amount of Nutritional Intake as a Possible Cause of Hyperglycemia in Extremely Premature Infants in Parenteral and Enteral Nutrition at the Tertiary Neonatal Intensive Care Unit

Predanič Drobne,

Kornhauser Cerar,

Erčulj

et al. 2023

Children

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Background: This study aimed to find an association between infants who had hyperglycemia and those who did not, those treated with insulin or not and several prenatal and postnatal variables or the suboptimal prescription of parenteral nutrition. Methods: We conducted a retrospective study, which included extremely premature infants (<28 weeks of gestation) admitted to the tertiary NICU, University Medical Centre Ljubljana, between 1 January 2021 and 31 December 2021. Blood glucose measurements, insulin treatment, general characteristics, nutritional data and complications of prematurity were obtained retrospectively from hospital data. RESULTS: There were 21 infants included in the study who did not receive insulin and 17 who were treated with insulin. Infants receiving insulin were younger and lighter compared to the non-insulin treatment group (mean gestational age 178 vs. 188 days; median birth weight 680 g vs. 990 g). The younger insulin group of infants received the same daily number of total macronutrients per kg per day compared to the older non-insulin group, i.e., glucose, lipids and amino acids, as recommended for the gestational age and birth weight. After adjusting for gestational age, no significant association with complications of prematurity was found. Conclusions: The postulated explanation (with the prescription of a higher amount of macronutrients during the first seven days) for hyperglycemia and treatment with insulin in the less mature and lighter infants cannot be supported by the data given.

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Prematurity at less than 24 weeks of gestation is a risk for prolonged hyperglycemia in extremely low-birth weight infants

Cited by 2 publications

References 26 publications

Risk factors for hyperglycemia in extremely low birth weight infants during the first 14 days

Risk factors for hyperglycemia in extremely low birth weight infants during the first 14 days

A Higher Amount of Nutritional Intake as a Possible Cause of Hyperglycemia in Extremely Premature Infants in Parenteral and Enteral Nutrition at the Tertiary Neonatal Intensive Care Unit

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