Premedicación con ketamina-midazolam oral en pacientes no colaboradores en cirugía mayor ambulatoria

Cortiñas, M.; Oya, Bahriye; Caparrós, Paula Jaén; Cano, Galo Guillermo Farfán; Ibarra, Marta Carolina; Martínez, Luis Alberto Corona

doi:10.1016/s0034-9356(10)70708-8

Cited by 8 publications

(4 citation statements)

References 19 publications

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“…Ketamine is an N-methyl-d-aspartate receptor antagonist exerting a desirable sedative and analgesic effect (7). When administered orally, as a sole premedication, it produces adverse effects such as salivation and anxiety (8).…”

Section: Introductionmentioning

confidence: 99%

Comparison of Intranasal Dexmedetomidine and Oral Ketamine Versus Intranasal Midazolam Premedication for Children Undergoing Dental Rehabilitation

Oriby

2019

Anesth Pain Med

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BackgroundDental rehabilitation surgery is associated with significant fear and anxiety with subsequent psychological disturbances. Midazolam has been used frequently as a premedication. However, it may be associated with side effects. Dexmedetomidine and ketamine combination has been suggested as an effective premedication in improving preoperative sedation and analgesia.ObjectivesThis study compared the effects of combined intranasal dexmedetomidine and oral ketamine versus intranasal midazolam on anxiolysis and postoperative analgesia.MethodsSeventy-six children (aged two to six years) undergoing dental rehabilitation under general anesthesia were assigned randomly to one of the two groups (n = 38 each) receiving either intranasal dexmedetomidine at 2 µg/kg and oral ketamine at 3 mg/kg (Group DK) or intranasal midazolam at 0.2 mg/kg (group M) 30 minutes prior to the anesthesia induction. The sedation levels and parental separation state were evaluated. Time to recovery, postoperative rescue analgesia, and postoperative adverse effects were assessed.ResultsSeventy-six children completed the study. Patients in group DK had significantly lower sedation scores than those in group M after 20 and 30 min (P < 0.05). The rate of satisfactory separation showed no statistically significant difference between the two groups 30 minutes after the administration of premedication (P = 0.926). A significantly higher number of patients in group M required rescue analgesic (42%) compared to those in group DK (16%) (P = 0.012).ConclusionsPremedication with intranasal dexmedetomidine 2 µg/kg and oral ketamine 3 mg/kg is a rapid and effective alternative in children undergoing dental rehabilitation when compared to intranasal midazolam 0.2 mg/kg.

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Section: Introductionmentioning

confidence: 99%

Comparison of Intranasal Dexmedetomidine and Oral Ketamine Versus Intranasal Midazolam Premedication for Children Undergoing Dental Rehabilitation

Oriby

2019

Anesth Pain Med

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“…Hanamoto et al showed that oral midazolam was more efficient than that provided through intramuscular route [7], while ketamine had good oral bioavailability and norketamine, its first-pass metabolite, was fully active with analgesic properties [8]. Even if lower doses of ketamine and midazolam than those reported in literature were used [4][5][6][7][8], easy preoperative management was allowed, without delaying patient's extubation and postoperative recovery time, as already demonstrated by Trabold et al in children [9]. The patient did not experience postoperative nausea and vomiting, thanks to intraoperative low opioid use and dexamethasone and ondansetron prophylaxis [10].…”

Section: Discussionmentioning

confidence: 99%

Anesthetic Management of an Adult Patient With Down Syndrome for Thoracic Surgery

Pelli¹,

Loffredo²,

Menna³

et al. 2021

Cureus

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The anesthetic management of adult patient with Down syndrome (DS) can be challenging due to poor patient cooperation, age-related comorbidities, and a possible difficult airway. Thoracic anesthesia requires an advanced airway management; thus, treatment of DS patients can be particularly demanding. An accurate preoperative assessment is paramount in order to plan a well-designed perioperative strategy in advance. This report describes the anesthetic management of an adult patient affected by DS who underwent pleural decortication for pleural empyema.

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“…[7] Even drugs such as ketamine are used for premedication effectively in mentally disabled patients undergoing major dental surgery, without any increase in the incidence of side effects. [8]…”

Section: Pre-anaesthetic Evaluationmentioning

confidence: 99%

Changing concepts in anaesthesia for day care surgery

Harsoor¹

2010

Indian J Anaesth

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Premedicación con ketamina-midazolam oral en pacientes no colaboradores en cirugía mayor ambulatoria

Cited by 8 publications

References 19 publications

Comparison of Intranasal Dexmedetomidine and Oral Ketamine Versus Intranasal Midazolam Premedication for Children Undergoing Dental Rehabilitation

Comparison of Intranasal Dexmedetomidine and Oral Ketamine Versus Intranasal Midazolam Premedication for Children Undergoing Dental Rehabilitation

Anesthetic Management of an Adult Patient With Down Syndrome for Thoracic Surgery

Changing concepts in anaesthesia for day care surgery

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