Premedication with controlled-release oxycodone does not improve management of postoperative pain after day-case gynaecological laparoscopic surgery

Jokela, R.; Ahonen, Jouni; Valjus, M.; Seppαlä, Timo; Korttila, K.

doi:10.1093/bja/ael342

Cited by 27 publications

(22 citation statements)

References 24 publications

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“…Results of our study are similar to those by Jokela et al 9 These authors also found no improvement in postoperative pain scores after pre-medication with 15 mg of oxycodone CR in day-case gynaecological laparoscopic surgery patients. This is in contrast to a similar study by Reuben et al 8 who showed a reduction in the consumption of rescue pain analgesics, VAS scores, incidence of All authors contributed to conception and design, manuscript preparation, read and approved the final manuscript.…”

Section: Discussionsupporting

confidence: 91%

Pre-medication with controlled-release oxycodone in the management of postoperative pain after ambulatory laparoscopic gynaecological surgery

Lim¹,

Thong²,

Zhu³

et al. 2013

OA Case Reports

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IntroductionOxycodone controlled-release is a potent opioid analgesic. We aim to assess the efficacy of pre-medication of oral oxycodone controlled-release in the reduction of postoperative pain in ambulatory laparoscopic gynaecological surgery. Materials and MethodsA randomised, double blind, placebocontrolled trial was performed. This was conducted in 60 patients undergoing ambulatory laparoscopic gynaecological surgery. They were randomised into two groups to receive either oral oxycodone controlled-release 10 mg (Group C, n = 30) or placebo (Group P, n = 30 ) 1 h preoperatively. Postoperative pain score and side effects of oxycodone controlled-release were assessed in the recovery room. Rescue analgesia of intravenous fentanyl (25 μg every 15 min) was given in the recovery room until the numerical rating pain score was ≤5. These patients were followed up 24 h postoperatively via telephone questionnaire. ResultsWe found no difference in pain scores at rest or on exertion at 15 min, 1 h, 2 h or 24 h after the surgery between the two groups of patients. In

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Section: Discussionsupporting

confidence: 91%

Pre-medication with controlled-release oxycodone in the management of postoperative pain after ambulatory laparoscopic gynaecological surgery

Lim¹,

Thong²,

Zhu³

et al. 2013

OA Case Reports

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“…The standard deviation (SD) in the reference study [12] was 1.3 in the placebo group at this time point. The minimal target difference (TD) with clinical significance is 1 point of VAS.…”

Section: Discussionmentioning

confidence: 87%

“…Sample size calculation was based on a visual analogue score (VAS) for pain at rest calculated in the reference study [12] in the first hour after the end of anesthesia. The standard deviation (SD) in the reference study [12] was 1.3 in the placebo group at this time point.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast with these results, Jokela et al [12] have recently shown that premedication with controlledrelease oxycodone does not improve management of postoperative pain after day-case gynecological laparoscopic surgery. Controlled-release oxycodone has shown high bioavailability, which contributes to modest interindividual variability after oral administration [13].…”

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confidence: 84%

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Preoperative administration of controlled-release oxycodone as a transition opioid for total intravenous anaesthesia in pain control after laparoscopic cholecystectomy

et al. 2008

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“…The higher frequency of constipation in that study can be explained by the time of opioid use, which was longer than in our study, limited to two days. Jokela et al studied premedication with 15 mg controlled-release oxycodone in gynecological laparoscopic operations and found 25% of nausea and vomiting 17 . The higher frequency could be explained by the different type of operation, since the gynecological laparoscopic operations may cause a higher incidence of nausea and vomiting compared with head and neck procedures.…”

Section: Discussion Discussion Discussion Discussion Discussionmentioning

confidence: 99%

Safety and tolerability of controlled-release oxycodone on postoperative pain in patients submitted to the oncologic head and neck surgery

Cavalcanti

Carvalho

Musauer

et al. 2014

Rev. Col. Bras. Cir.

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Safety and tolerability of controlled-release oxycodone on Safety and tolerability of controlled-release oxycodone on Safety and tolerability of controlled-release oxycodone on Safety and tolerability of controlled-release oxycodone on Safety and tolerability of controlled-release oxycodone on postoperative pain in patients submitted to the oncologic head postoperative pain in patients submitted to the oncologic head postoperative pain in patients submitted to the oncologic head postoperative pain in patients submitted to the oncologic head postoperative pain in patients submitted to the oncologic head and neck surgery and neck surgery and neck surgery and neck surgery and neck surgery Segurança e tolerabilidade da oxicodona de liberação controlada em dores pós-Segurança e tolerabilidade da oxicodona de liberação controlada em dores pós-Segurança e tolerabilidade da oxicodona de liberação controlada em dores pós-Segurança e tolerabilidade da oxicodona de liberação controlada em dores pós-Segurança e tolerabilidade da oxicodona de liberação controlada em dores pós-operatórias em pacientes submetidos à operações oncológicas de cabeça e operatórias em pacientes submetidos à operações oncológicas de cabeça e operatórias em pacientes submetidos à operações oncológicas de cabeça e operatórias em pacientes submetidos à operações oncológicas de cabeça e operatórias em pacientes submetidos à operações oncológicas de cabeça e pescoço pescoço pescoço pescoço pescoço We conducted a prospective, observational and open study, with 83 patients with moderate to severe pain after head and neck oncological operations. All patients received general anesthesia with propofol, fentanyl and sevoflurane. Postoperatively, should they have moderate or severe pain, we began controlled-release oxycodone 20 mg 12/12 b.i.d on the first day and 10 mg b.i.d. on the second. We assessed the frequency and intensity of adverse effects, the intensity of postoperative pain by a verbal numeric scale and the use of rescue analgesia from 12 hours after administration of the drug and between 7 and 13 days after the last oxycodone dose. Results Results ResultsResults Results: The most common adverse events were nausea, vomiting, dizziness, pruritus, insomnia, constipation and urinary retention, most mild. No serious adverse events occurred. In less than 12 hours after the use of oxycodone, there was a significant decrease in the intensity of postoperative pain, which remained until the end of the study. The rescue medication was requested at a higher frequency when the opioid dose was reduced, or after its suspension. Conclusion Conclusion Conclusion Conclusion Conclusion: Controlled release oxycodone showed to be safe and well tolerated and caused a significant decrease in postoperative pain.

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Premedication with controlled-release oxycodone does not improve management of postoperative pain after day-case gynaecological laparoscopic surgery

Abstract: Oral premedication with CR oxycodone did not improve management of postoperative pain after day-case gynaecological laparoscopic surgery.

Cited by 27 publications

References 24 publications

Pre-medication with controlled-release oxycodone in the management of postoperative pain after ambulatory laparoscopic gynaecological surgery

Pre-medication with controlled-release oxycodone in the management of postoperative pain after ambulatory laparoscopic gynaecological surgery

Preoperative administration of controlled-release oxycodone as a transition opioid for total intravenous anaesthesia in pain control after laparoscopic cholecystectomy

Safety and tolerability of controlled-release oxycodone on postoperative pain in patients submitted to the oncologic head and neck surgery

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