Premedication With Oral Pregabalin for the Prevention of Acute Postsurgical Pain in Coronary Artery Bypass Surgery

Ziyaeifard, Mohsen; Mehrabanian, Mohammad Javad; Faritus, Seyedeh Zahra; Koohpar, Mehrdad Khazaei; Ferasatkish, Rasool; Hosseinnejad, Heidar; Mehrabanian, Mohammadreza

doi:10.5812/aapm.24837

Cited by 25 publications

(15 citation statements)

References 22 publications

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“…Pregabalin has been used in different types of surgery and published clinical studies suggest that chronic pain may be reduced in patients who receive perioperative pregabalin [ 24 , 26 ], but data on the role of pregabalin in cardiac surgery are limited: Ziyaeifard et al [ 34 ] reported that a single preoperative dose of pregabalin 150 mg significantly reduced pain but had no effect on morphine consumption after elective CABG surgery, whereas Joshi and Jagadeesh reported that one pregabalin dose before and one daily pregabalin dose for two days after surgery reduced pain scores and tramadol consumption for 36 hours but had no effect on chronic postoperative pain in patients undergoing off-pump coronary artery bypass (OPCAB) surgery [ 35 ]. However, a prospective clinical trial by Pesonen et al showed that although perioperative pregabalin significantly reduced perioperative oxycodone consumption and the incidence of confusion, it increased the time to extubation in elderly patients undergoing cardiac surgery [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Pregabalin Effect on Acute and Chronic Pain after Cardiac Surgery

Bouzia¹,

Tassoudis

Καρανικόλας

et al. 2017

Anesthesiology Research and Practice

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Introduction. Pain after cardiac surgery affects long-term patient wellness. This study investigated the effect of preoperative pregabalin on acute and chronic pain after elective cardiac surgery with median sternotomy. Methods. Prospective double blind study. 93 cardiac surgery patients were randomly assigned into three groups: Group 1 received placebo, Group 2 received oral pregabalin 75 mg, and Group 3 received oral pregabalin 150 mg. Data were collected 8 hours, 24 hours, and 3 months postoperatively. Results. Patients receiving pregabalin required fewer morphine boluses (10 in controls versus 6 in Group 1 versus 4 in Group 2, p = 0.000) and had lower pain scores at 8 hours (4 versus 3 versus 3, p = 0.001) and 3 months (3 versus 2 versus 2, p = 0.000) and lower morphine consumption at 8 hours (14 versus 13 versus 12 mg, p = 0.000) and 24 hours (19.5 versus 16 versus 15 mg, p = 0.000). Percentage of patients with sleep disturbances or requiring analgesics was lower in the pregabalin group and even lower with higher pregabalin dose (16/31 versus 5/31 versus 3/31, p = 0.000, and 26/31 versus 16/31 versus 10/31, p = 0.000, resp.) 3 months after surgery. Conclusion. Preoperative oral pregabalin 75 or 150 mg reduces postoperative morphine requirements and acute and chronic pain after cardiac surgery.

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Section: Discussionmentioning

confidence: 99%

Pregabalin Effect on Acute and Chronic Pain after Cardiac Surgery

Bouzia¹,

Tassoudis

Καρανικόλας

et al. 2017

Anesthesiology Research and Practice

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“…In one study, administration of 150 mg of pregabalin prior to inducting anesthesia reduced pain scores and opioid consumption after hysterectomy 16. With pregabalin 150 mg prior to myocardial revascularization surgery, there was a decrease in pain intensity after 4, 12, and 24 hours 17. A systematic review showed that a single preoperative dose of 100–300 mg was effective, with no difference between doses 5…”

Section: Discussionmentioning

confidence: 99%

Effect of preoperative pregabalin on analgesia and interleukins after lumbotomy: prospective, randomized, comparative, double-blind study

Santiago

Leal

Moura

et al. 2019

JPR

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BackgroundPregabalin is an anticonvulsant and has been used for postoperative analgesia. This study aimed to assess the effect of a single preoperative dose of pregabalin for analgesia after nephrectomy.MethodsThe study was prospective, randomized, comparative, and double-blinded, conducted in 40 kidney transplant donors, between 18 and 60 years, American Society of Anesthesia physical status I or II. Epidural anesthesia was performed with 15 mL of 0.5% ropivacaine single shot and general anesthesia with 3 µg/kg of fentanyl, propofol, atracurium, and sevoflurane, and 50% of oxygen without nitrous oxide. Patients in group 1 were administered 300 mg of pregabalin and those in group 2 were administered placebo, in identical capsules, 1 hour prior to surgery. Postoperative analgesia was supplemented with tramadol. The following parameters were assessed: pain intensity after 6 and 24 hours; pain threshold, from the thenar and peri-incisional region, analgesic supplementation; ILs (IL6, IL8, and IL10) prior to surgery and after 6 and 24 hours.ResultsThe pain intensity was lower with pregabalin after 24 hours (G1: 2.5±2.4, G2: 3.0±2.6). There was no difference in the sensitivity of the thenar and peri-incisional region after 6 and 24 hours; in the number of patients requiring supplementation (G1=15%, G2=45%); concentrations of IL-6, IL-8, and IL-10; and side effects (nausea, vomiting, dizziness, and pruritus).ConclusionPregabalin in a single preoperative dose of 300 mg reduced pain intensity 24 hours after lumbotomy.

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“…43 44 The present study was designed with the primary aim of examining whether the addition of pregabalin to a perioperative THA analgesic regimen (which includes spinal anaesthesia and perioperative celecoxib) while in hospital and for 1 week postdischarge improves pain and functional outcomes up to 3 months after surgery. The present study did not find significant differences between pregabalin and placebo groups in the primary measures of function (both physical and patient reported) at 6 weeks or 3 months after THA (Table 2).…”

Section: Discussionmentioning

confidence: 99%

Pregabalin reduces postoperative opioid consumption and pain for 1 week after hospital discharge, but does not affect function at 6 weeks or 3 months after total hip arthroplasty

Clarke

Pagé

McCartney

et al. 2015

British Journal of Anaesthesia

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Background: This study examined whether a perioperative regimen of pregabalin added to celecoxib improved pain scores and functional outcomes postdischarge up to 3 months after total hip arthroplasty (primary outcome) and acute postoperative pain and adverse effects (secondary outcomes). Methods: One hundred and eighty-four patients were enrolled in a randomized, double-blind, placebo-controlled study. Two hours before receiving a spinal anaesthetic and undergoing surgery, patients received celecoxib 400 mg p.o. and were randomly assigned to receive either pregabalin 150 mg p.o. or placebo p.o. After surgery, patients received pregabalin 75 mg or placebo twice daily in hospital and for 7 days after discharge. Patients also received celecoxib 200 mg every 12 h for 72 h and morphine i.v. patient-controlled analgesia for 24 h. Pain and function were assessed at baseline, 6 weeks, and 3 months after surgery. Results: There was no difference between groups in physical function or incidence and intensity of chronic pain 3 months after total hip arthroplasty. The pregabalin group used less morphine [mean (): 39.85 (28.1) mg] than the placebo group [54.01 (31.2) mg] in the first 24 h after surgery (P<0.01). Pain scores were significantly lower in the pregabalin group vs the placebo group on days 1-7 after hospital discharge, and the pregabalin group required less adjunctive opioid medication (Percocet) 1 week after hospital discharge (P<0.05). Conclusions: Perioperative administration of pregabalin did not improve pain or physical function at 6 weeks or 3 months after total hip arthroplasty. Perioperative administration of pregabalin decreased opioid consumption in hospital and reduced daily pain scores and adjunct opioid consumption for 1 week after discharge.

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Premedication With Oral Pregabalin for the Prevention of Acute Postsurgical Pain in Coronary Artery Bypass Surgery

Cited by 25 publications

References 22 publications

Pregabalin Effect on Acute and Chronic Pain after Cardiac Surgery

Pregabalin Effect on Acute and Chronic Pain after Cardiac Surgery

Effect of preoperative pregabalin on analgesia and interleukins after lumbotomy: prospective, randomized, comparative, double-blind study

Pregabalin reduces postoperative opioid consumption and pain for 1 week after hospital discharge, but does not affect function at 6 weeks or 3 months after total hip arthroplasty

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