Premeiotic Origin of Teratomas: Is Meiosis Required for Differentiation into Mature Tissues?

Zhuang, Zhengping; Devouassoux‐Shisheboran, Mojgan; Lubensky, Irina A.; Tavassoli, Fattaneh A.; Vortmeyer, Alexander O.

doi:10.4161/cc.4.11.2190

Cited by 9 publications

(7 citation statements)

References 8 publications

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“…43 It has also been suggested that malignant transformation of the stroma may be either through the transformation of differentiated elements or through progression of totipotential germ cells in the teratoma. 1,18,35,44,45 All of these clinical and laboratory observations support that the stroma of testicular teratomas of men is not simply composed of coexisting accessory cells but that it is an integral neoplastic teratoma component.…”

Section: Discussionmentioning

confidence: 75%

Molecular genetic evidence supporting the neoplastic nature of fibrous stroma in testicular teratoma

et al. 2012

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Testicular teratoma typically consists of heterogeneous mixtures of diverse epithelial and stromal components. The biological nature and genetic characteristics of the fibrous stroma of testicular teratomas have not been thoroughly investigated. Chromosome 12p abnormalities are the hallmark genetic alterations of germ cell tumors. We studied chromosome 12p abnormalities in the fibrous stroma and other components of pure testicular teratomas from 32 patients using interphase fluorescence in situ hybridization. Overall, 72% (23/32) of pure testicular teratomas had chromosome 12p abnormalities. Isochromosome 12p or 12p overrepresentation independent of isochromosome 12p was detected in the fibrous stroma in 53% (17/32) and 41% (13/32) of cases, respectively. Among the 17 cases positive for isochromosome 12p, 8 (47%) also had 12p overrepresentation. In 31% (10/32) cases, the fibrous stroma showed neither 12p overrepresentation nor isochromosome 12p. Isochromosome 12p and 12p overrepresentation were identified, respectively, in the gastrointestinal-type epithelium of 14/23 (61%) and 15/23 (65%) cases; in the respiratory-type epithelium of 41% (7/17) and 41% (7/17) cases; in the squamous epithelium of 62% (8/13) and 54% (7/13) cases; and in the cartilage of 63% (5/8) and 38% (3/8) cases. Concordant chromosomal 12p abnormalities were observed between the fibrous stroma and epithelial elements of testicular teratomas. Our results indicate that the fibrous stroma of testicular teratomas frequently has genetic abnormalities similar to those of the epithelial components. Concordant chromosome 12p alterations between the fibrous stroma and epithelial elements provide further evidence that both epithelial and fibrous components of teratoma are derived from a common progenitor.

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Section: Discussionmentioning

confidence: 75%

Molecular genetic evidence supporting the neoplastic nature of fibrous stroma in testicular teratoma

et al. 2012

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“…As indicated earlier, mature cystic teratomas are heterozygous in a substantial minority of cases, indicating that they can originate from a premeiotic germ cell (93,94). Furthermore, a recent study indicated that the immature elements in immature teratomas are also heterozygous (97). Because cases with heterozygous DNA in the teratomas were interpreted as being noninformative, there would be no way to identify cases that might represent tumor spread to the peritoneum from the primary ovarian teratoma.…”

Section: Pathogenesis Of Germ Cell Tumorsmentioning

confidence: 89%

“…In the remaining case, the malignant component revealed homozygosity of different alleles compared with the mature teratoma, suggesting 2 independent teratomatous growth processes. In a more recent investigation, mature and immature components were procured from immature teratomas (97). The immature teratomatous tissue had a heterozygous genotype, whereas remarkably, the mature tissue components within the immature teratoma showed homozygosity, suggesting that immature teratomas arise from premeiotic cells and that meiosis may be required for differentiation into mature tissues.…”

Section: Pathogenesis Of Germ Cell Tumorsmentioning

confidence: 97%

Recent Advances in the Pathology and Classification of Ovarian Germ Cell Tumors

Roth

Talerman²

2006

International Journal of Gynecological Pathology

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In recent years, our knowledge of ovarian germ cell tumors has increased, and their classification has evolved. The introduction of cisplatin-based chemotherapy and the discovery of tumor markers, including alpha-fetoprotein and human chorionic gonadotropin, have dramatically changed the clinical outlook for most of these patients. In this review, recent advances in the classification and pathology of ovarian germ cell tumors are discussed. Where appropriate, comparisons are made with testicular germ cell tumors. The last section of the article discusses the pathogenesis of germ cell tumors. This review will emphasize the articles written in the last 10 years and those that have significantly advanced our knowledge of germ cell tumors in past decades.

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“…This theory suggests an initiating event in premeiotic cells causes continuous proliferation, resulting in immature and heterozygous tissues, while cells that proceed through the meiotic pathway create homozygous and mature components 17. In this model, meiosis is required for tissue maturation and is responsible for homozygosity 17. Yet, in this study, we have demonstrated that both mature heterozygous and homozygous tissue can occur within a single MOT.…”

Section: Discussionmentioning

confidence: 63%

“…The other possibility of a somatic origin has not gained sufficient attention. Interestingly, immature teratomatous elements were subsequently found to be heterozygous, resulting in the premeiotic hypothesis of immature teratomas and possibly a subset of mature teratomas 17. This theory suggests an initiating event in premeiotic cells causes continuous proliferation, resulting in immature and heterozygous tissues, while cells that proceed through the meiotic pathway create homozygous and mature components 17.…”

Section: Discussionmentioning

confidence: 99%

Heterozygous bone marrow in a homozygous mature ovarian teratoma: a challenge to the germ cell theory or incidental somatic heterotopia?

Munday

Hui

2015

J Clin Pathol

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Premeiotic Origin of Teratomas: Is Meiosis Required for Differentiation into Mature Tissues?

Cited by 9 publications

References 8 publications

Molecular genetic evidence supporting the neoplastic nature of fibrous stroma in testicular teratoma

Molecular genetic evidence supporting the neoplastic nature of fibrous stroma in testicular teratoma

Recent Advances in the Pathology and Classification of Ovarian Germ Cell Tumors

Heterozygous bone marrow in a homozygous mature ovarian teratoma: a challenge to the germ cell theory or incidental somatic heterotopia?

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