Premenarchal and postmenarchal girls with insulin-dependent diabetes mellitus: Ovarian and other organ-specific autoantibodies, menstrual cycle

Šnajderová, Marta; Martínek, J; Horejsí, J; Nováková, Dana; Lebl, Jan; Koloušková, Stanislava

doi:10.1016/s1083-3188(99)00023-6

Cited by 29 publications

(24 citation statements)

References 21 publications

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“…The longer the premenarcheal period with T1DM, the greater was the delay in the onset of first menses. This observation lends support to the hypothesis that, in the presence of diabetes mellitus, antibodies to ovarian cells impair ovarian function [29]. Thus, the earlier the onset of T1DM occurs during the prepubertal period, the greater is the likelihood that such antibodies could have already formed and resulted in ovarian functional impairment.…”

Section: Discussionsupporting

confidence: 77%

Delayed menarche in young German women with type 1 diabetes mellitus: recent results from the DPV diabetes documentation and quality management system

et al. 2007

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Section: Discussionsupporting

confidence: 77%

Delayed menarche in young German women with type 1 diabetes mellitus: recent results from the DPV diabetes documentation and quality management system

et al. 2007

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“…The longer the premenarcheal period with type 1 diabetes, the greater was the delay in the onset of first menses. This observation lends support to the hypothesis that, in the presence of diabetes mellitus, antibodies to ovarian cells impair ovarian function (30). Thus, the earlier the onset of type 1 diabetes occurs during the prepubertal period, the greater is the likelihood that such antibodies could have already formed and resulted in ovarian functional impairment.…”

Section: Discussionsupporting

confidence: 77%

Delayed pubertal onset and development in German children and adolescents with type 1 diabetes: cross-sectional analysis of recent data from the DPV diabetes documentation and quality management system

Rohrer

Stierkorb²,

Heger

et al. 2007

European Journal of Endocrinology

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Objective: To investigate the effect of type 1 diabetes on pubertal onset and development, and to identify factors potentially affecting puberty, including glycemic control, relative diabetes duration, body mass index standard delta score (BMI SDS), insulin dose, and intensity of insulin therapy. Research design and methods: Initiated in 1990, the Diabetes-Patienten-Verlaufsdaten (DPV) is an ongoing, prospective longitudinal follow-up program to benchmark the quality of diabetes care provided to, predominantly, pediatric patients. Data collection for this non-interventional audit was carried out at 202 German diabetes treatment centers. Patient recruitment was done by referral, clinic/hospital ascertainment, or self-report. Data were analyzed for subcohorts of 1218-2409 boys and 579-2640 girls from a cohort of 24 385 pediatric type 1 diabetic patients. Selection was based on ethnicity and availability of data on Tanner stage 2, or higher, of genital and pubic hair development (boys) or breast and pubic hair development, and menarche (girls). Results: Boys showed significant (P!0.05) delay (years) in mean ages at onset of genital development (12.0 (G0.9) years) and pubarche (12.2 (G0.4) years). In girls, mean ages at thelarche (11.4 (G0.5) years), pubarche (11.5 (G0.1) years), and menarche (13.2 (G0.5) years) were significantly delayed compared with the general population. Sexual maturity (Tanner stage 5) was not delayed in either sex. Elevated glycohemoglobin and decreased BMI SDS were associated with significantly delayed pubertal onset, whereas relative diabetes duration and insulin dose were not. Conclusions: Pubertal onset, but not sexual maturity, is delayed in children with type 1 diabetes. Delay increases with higher glycohemoglobin and lower BMI SDS.European Journal of Endocrinology 157 647-653

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“…20 However, the findings of other studies have suggested that the mean age of menarche in adolescents with age of diabetes onset older than 11 years is delayed by 1 year compared to adolescents with age of diabetes onset older than 11 years and compared to control group adolescents. 21 These findings are not comparable with our findings because the sample was not clearly defined and the researchers used a different methodology.…”

Section: Discussionmentioning

confidence: 91%

Age at Menarche and Menstrual Irregularities of Adolescents with Type 1 Diabetes

Δελτσίδου

2010

Journal of Pediatric and Adolescent Gynecology

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Premenarchal and postmenarchal girls with insulin-dependent diabetes mellitus: Ovarian and other organ-specific autoantibodies, menstrual cycle

Cited by 29 publications

References 21 publications

Delayed menarche in young German women with type 1 diabetes mellitus: recent results from the DPV diabetes documentation and quality management system

Delayed menarche in young German women with type 1 diabetes mellitus: recent results from the DPV diabetes documentation and quality management system

Delayed pubertal onset and development in German children and adolescents with type 1 diabetes: cross-sectional analysis of recent data from the DPV diabetes documentation and quality management system

Age at Menarche and Menstrual Irregularities of Adolescents with Type 1 Diabetes

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