“…2 The common symptoms of PMDD are excessive tension, irritability, desperate mood, depression, extreme anger, decreased interest in daily activity, and low self-esteem. 1,2,6,7 Not all women with PMS symptoms experience PMDD symptoms, but all women with PMDD symptoms also experience PMS symptoms. 3,8 PMS symptoms begin after menarche between age 14 and 17 years, and the most serious symptoms are observed between ages 25 and 35 years.…”