Premenstrual Syndrome and Anxiety Disorders: A Psychobiological Link

Facchinetti, Fabio; Tarabusi, M.; Nappi, Giuseppe

doi:10.1159/000012260

Cited by 22 publications

(9 citation statements)

References 16 publications

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“…Although panic-like response to lactate infusions is most consistent in panic disorder, some sensitivity to lactate infusions have been reported in post-traumatic stress disorder, where it primarily induces flash-backs (Rainey et al, 1987;Jensen et al, 1997), and a subset of patients with premenstrual syndrome (Facchinetti et al, 1992;Sandberg et al, 1993). A disorder that also shares a biological linkage with panic disorder (Facchinetti et al, 1998). In contrast, lactate infusions are ineffective in patients with obsessive compulsive disorder , social anxiety disorder and major depression without history of panic attacks (Cowley et al, 1987).…”

Section: Discussionmentioning

confidence: 99%

Chronic inhibition of GABA synthesis in the bed nucleus of the stria terminalis elicits anxiety-like behavior

et al. 2008

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The current study tested the hypotheses that chronic loss of inhibitory GABAergic tone in the bed nucleus of the stria terminalis (BNST), a region implicated in anxiety behavior, results in generalized anxiety disorder-like behaviors without panic-like responses (i.e., tachycardia, hypertension and tachypnea) following panicogenic stimuli (e.g., sodium lactate infusions). To test this hypothesis, the GABA synthesis inhibitor L-allylglycine (L-AG) or its inactive isomer D-AG was chronically infused into the BNST of male rats via osmotic minipumps. L-AG, but not D-AG, treated rats had increased anxiety-like behavior as measured by social interaction (SI) and elevated plus maze paradigms. Restoring GABAergic tone, with 100pmoles/100nl of muscimol (a GABAA receptor agonist), in the BNST of L-AG treated rats attenuated L-AG-induced anxiety-like behavior in the SI test. To assess panic-like states, L-AG treated rats were intravenously infused with 0.5M sodium lactate, a panicogenic agent, prior to assessing SI and cardiorespiratory responses. L-AG decreased SI duration again; however, sodium lactate did not induce panic-like cardiorespiratory responses. These findings demonstrate that GABA inhibition in the BNST elicits anxiety-like behavior without increasing sensitivity to lactate, thus suggesting a behavioral profile similar to that of generalized anxiety-like behavior rather than that of panic.

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Section: Discussionmentioning

confidence: 99%

Chronic inhibition of GABA synthesis in the bed nucleus of the stria terminalis elicits anxiety-like behavior

et al. 2008

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“…In the CBT group, the number of cases with PMDD at the follow-up was smaller than in the fluoxetine group [23]. These results show the potential of CBT as a promising treatment option resulting in long-term stable improvements and indicate the important role of coping strategies [24]. However, these findings require further investigation.…”

Section: Introductionmentioning

confidence: 99%

Internet-Based Cognitive-Behavioural Intervention for Women with Premenstrual Dysphoric Disorder: A Randomized Controlled Trial

Weise

Kaiser

Janda

et al. 2019

Psychother Psychosom

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Background: Given the high prevalence of clinically relevant premenstrual symptoms and the associated impairment, there is a need for effective treatments. Initial evidence suggests cognitive-behavioural therapy (CBT) as an effective treatment for premenstrual dysphoric disorder (PMDD). The aim of the current randomized clinical trial was to evaluate an Internet-based CBT (iCBT) to reduce the burden of PMDD. Methods: In all, 174 women with PMDD were recruited via newspaper articles, flyers, and social media. They were randomized to a treatment group (TG; n = 86) or waitlist control group (CG; n = 88). Women of the TG received an 8-week therapist-guided iCBT. Data were assessed before and after treatment/waiting, and 6 months after intervention with prospective symptom diaries and questionnaires in the premenstrual phase. Treatment effects and moderators were analysed using hierarchical linear modelling. Results: Significant time × group interaction effects on functional impairment and psychological impairment, impact on everyday life, symptom intensity, and symptom disability in favour of the TG indicated the efficacy of the treatment. Follow-up assessments demonstrated treatment effects to be stable until 6 months after treatment. Additionally, significant interactions with moderator variables were found. In the TG, higher levels of active coping and lower levels of support-seeking coping were associated with stronger improvement in interference in everyday life and symptom intensity. In addition, lower levels of perceived stress were associated with stronger improvement in functional impairment. Conclusion: The iCBT was highly effective in reducing the burden of PMDD. It appears to be particularly important to address coping styles and stress management in the treatment.

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“…3 Psychiatric disorders such as anxiety and depression are more common in patients with PMS than the general population. 2,4,5 A more severe form of PMS has recently been defined by the American Psychiatric Association in its Diagnostic and Statistical Manual of Mental Disorders (4th Edition-Text Revision) and has been termed premenstrual dysphoric disorder (PMDD). 6 Patients with PMDD are required to have five affective or physical symptoms beginning during the last week of the luteal phase and remitting during the week post menses.…”

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confidence: 99%