Background: Premenstrual syndrome (PMS) is a condition, which consists of cyclical physical, behavioral and psychological symptoms, which regularly recurs before period and disappears by the end of menstruation. Objectives: This study aims to estimate the prevalence, severity of PMS, and its impact on work productivity among a group of female doctors aged between (20-45) at King Fahad Armed Forces Hospital (KFAFH), Jeddah, Saudi Arabia. Methodology: A cross sectional study with a sample of female doctors (N=177) at King Fahad Armed Forces Hospital in Jeddah were included in the study, a self-administered questionnaire distributed among them included sociodemographic questions, premenstrual evaluating questionnaire including the American college of obstetrics & gynecology (ACOG) criteria, and questions about the effect on work using a valid work assessment questionnaire. Results: Prevalence of PMS found to be in 50.7% of female doctors, Most of cases with PMS are in the category borderline to mild (18%) and mild to moderate (16.3%). PMS had significant relation with overall work impairment. Saudi female doctors found to be more liable to PMS than non-Saudi. Conclusion: PMS was prevalent among female doctors at KFAFH, with significant overall work productivity loss.