Première série de décès en France liés à l’oxycodone

Aknouche, Frédéric; Guibert, Émilie; Tessier, Alison; Alvarez, Jean‐Claude; Lemaire-Hurtel, Anne-Sophie; Kintz, Pascal

doi:10.1016/j.toxac.2015.01.003

Cited by 3 publications

(1 citation statement)

References 3 publications

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“…After 15 minutes of agitation at room temperature, centrifugation (3000 rpm for 15 minutes) and evaporation to dryness at 45°C, the residue was reconstituted in 30 μL of mobile phase A and transferred to an injection vial. The analysis was performed with an ultra‐performance liquid chromatography tandem mass spectrometer (UPLC−MS/MS), according to two previously published procedures …”

Section: Methodsmentioning

confidence: 99%

Testing for midazolam and oxycodone in blood after formalin‐embalmment: About a complex medico‐legal case

Ameline

Raul

Kintz

2019

Drug Testing and Analysis

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The stability of compounds in formalin solution is an important factor for drug analysis in a toxicological investigation. In this article, the authors report a complex medico‐legal case involving midazolam and oxycodone. The complexity of this case comes from the fact that the body was embalmed with formalin solution before the autopsy. This technique, called thanatopraxy, allows the preservation of corpses from decomposition, the destruction of a maximal number of micro‐organisms, and the presentation of the body with a natural appearance to the family. Unfortunately, when thanatopraxy is performed before the collection of biological specimens, the toxicological results are not representative of the time of the death. In addition, the interpretation of the results is difficult, because formalin can cause oxidation of xenobiotics present in the body at the time of the death, alter the pH of the tissues and dilute the compounds. To document the chemical stability of midazolam and oxycodone in formalin solution and interpret the results, a stability study was conducted for 21 days. Blood containing midazolam and oxycodone was spiked with formalin, kept at 4°C and regularly tested for both drugs. This study showed a rapid degradation of midazolam and oxycodone (85% during the first 24 hours for oxycodone). In the peripheral blood of the victim, methanol (1.31 g/L), midazolam (74ng/mL) and oxycodone (152 ng/mL) were identified. According to the stability study, the measured concentrations in formalin fixed‐tissues are to be interpreted very carefully, knowing that significant degradation has occurred.

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Section: Methodsmentioning

confidence: 99%

Testing for midazolam and oxycodone in blood after formalin‐embalmment: About a complex medico‐legal case

Ameline

Raul

Kintz

2019

Drug Testing and Analysis

Self Cite

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Doctor shopping of opioid analgesics relative to benzodiazepines: A pharmacoepidemiological study among 11.7 million inhabitants in the French countries

Ponté

Lepelley²,

Boucherie

et al. 2018

Drug and Alcohol Dependence

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Ten‐year trend of opioid and nonopioid analgesic use in the French adult population

Daveluy

Micallef

Sanchez-Peña³

et al. 2020

Brit J Clinical Pharma

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Aims Analgesics are the most widely used medicines worldwide. In parallel, opioid abuse has increased and is of major concern. The accessibility of pharmacologically powerful medicines and the addictovigilance signals in France about the risk of opiates addiction call for an overview of analgesic use. The objective of this study was to investigate the use of analgesics reimbursed in France over a 10‐year period through its prevalence. Methods A cross‐sectional study repeated yearly was conducted by using data from the French reimbursement database from 2006 to 2015. Analgesics were classified according to their pharmacological potency: prevalence of use for each category and sociodemographic characteristics of patients treated were analysed. Results The annual prevalence of analgesic use was high and increased during the study period (59.8%, 253 976 users in 2015). In 2015, prevalence was always higher in women and increased with age, except for those older than 84 years. Peripheral analgesics were the most used (55.3%, 234 739 users). The prevalence of weak analgesic use decreased (21.3%, 90 257 users), mainly due to the definitive withdrawal of dextropropoxyphene in France in 2011, which was not offset by an increase in the consumption of other weak analgesics. For strong analgesics (1.2%, 5129 users), morphine was the most widely used, with a dramatic increase in oxycodone use, especially in the elderly. Conclusion The prevalence of analgesic use is high: approximately 31 million adults had at least 1 analgesic reimbursed in 2015. The most widely used analgesics were peripheral analgesics, far ahead of opioid analgesics.

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Première série de décès en France liés à l’oxycodone

Cited by 3 publications

References 3 publications

Testing for midazolam and oxycodone in blood after formalin‐embalmment: About a complex medico‐legal case

Testing for midazolam and oxycodone in blood after formalin‐embalmment: About a complex medico‐legal case

Doctor shopping of opioid analgesics relative to benzodiazepines: A pharmacoepidemiological study among 11.7 million inhabitants in the French countries

Ten‐year trend of opioid and nonopioid analgesic use in the French adult population

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