Premorbid IQ in Schizophrenia: A Meta-Analytic Review

Woodberry, Kristen A.; Giuliano, Anthony J.; Seidman, Larry J.

doi:10.1176/appi.ajp.2008.07081242

Cited by 506 publications

(398 citation statements)

References 38 publications

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“…This is consistent with evidence that indicates that a lower premorbid level of intelligence may increase vulnerability to schizophrenia (52). In addition, intelligence may genetically overlap with known cognitive endophenotypes for schizophrenia (53).…”

Section: Developmental Disorders In "Adult Disguise"supporting

confidence: 90%

Rethinking the Concept of Psychosis and the Link Between Autism and Schizophrenia

Aggernæs

2015

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology

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Section: Developmental Disorders In "Adult Disguise"supporting

confidence: 90%

Rethinking the Concept of Psychosis and the Link Between Autism and Schizophrenia

Aggernæs

2015

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology

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“…In the literature, there is also a limited number of data confirming the occurrence of cognitive deficits in children and adolescents in the early stage of the schizophrenic process. These deficits, according to different authors, are similar to those of adult patients with schizophrenia [54,55,56,57].…”

Section: Resultssupporting

confidence: 64%

“…W literaturze istnieje także ograniczona liczba danych potwierdzających występowanie deficytów poznawczych u dzieci i młodzieży we wczesnym etapie procesu schizofrenicznego. Deficyty te według róż-nych autorów są zbliżone do tych stwierdzanych u osób dorosłych chorych na schizofrenię [54,55,56,57].…”

Section: Wyniki I Dyskusjaunclassified

Review paper. Neuropsychological dimension of schizophrenia - evaluation possibilities and therapeutic implications

Makarewicz

Karakuła-Juchnowicz

Łobejko

2017

Current Problems of Psychiatry

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Introduction: In the last decades, researchers' attention has been focused on cognitive dysfunction in schizophrenia. Numerous studies indicate the existence of neurodegenerative deficits in schizophrenia including, but not limited to, motor functions, learning and memory, executive functions, attention, language, spatial skills and general intelligence.Method: A review of available literature on the topic of the past two decades, available in the Pubmed, EBSCO, SCOPUS databases has been made using the keywords: schizophrenia, cognition, early intervention.Results: Cognitive dysfunction is an important feature of the prodromal phase and the first episode of schizophrenia. Researchers have thus proposed to initiate early therapeutic interventions for people with so-called risky mental conditions. The article includes the reference to research on neurocognitive disorders essence in schizophrenia, the definition and review of methods used to identify specific cognitive deficits and issues related to risk of developing psychosis and early therapeutic intervention in high-risk states.Conclusions: Researchers report the importance of detecting cognitive disorders in the early stages of schizophrenia. This broadens the range of therapeutic interventions and enables early intervention in the increased risk of psychosis.

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“…A significant IQ decline has been reported around the time of onset of COS [16] and adult schizophrenia [58]. As the baseline assessment in our study took place at the time of the first psychotic episode, it is possible that onsetrelated decline in intelligence continued in some patients after baseline assessment.…”

Section: Discussionmentioning

confidence: 82%

Course of intelligence deficits in early onset, first episode schizophrenia: a controlled, 5-year longitudinal study

Jepsen

Fagerlund

Pagsberg

et al. 2009

Eur Child Adolesc Psychiatry

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Only few prospective longitudinal studies have assessed the course of intelligence deficits in early onset schizophrenia (EOS), and these have used different age appropriate versions of Wechsler Intelligence Scales and age appropriate norms. The post-psychotic development of intelligence in EOS has predominantly been characterized as relatively stable in these studies. However, comparisons of IQs from different test versions based on the different norms may not permit unequivocal interpretations. The objective of the current study was to compare the development of intelligence in EOS patients (N = 10) from their first psychotic episode to 5 years of post onset with that of healthy controls (N = 35) and patients who at baseline had been diagnosed with other non-affective psychoses (N = 8). The same version of a Wechsler Intelligence Scale was administered at both baseline and follow-up assessments, and the same norms were used to derive IQs at baseline and followup. Significantly smaller change in mean full scale intelligence quotient (FSIQ) was found in diagnostically stable EOS patients compared with healthy controls during the follow-up period. However, no statistically significant difference in mean FSIQ change was observed between patients with EOS and patients with other non-affective psychoses, although this result must be interpreted with caution due to the small sample sizes. The results suggest abnormally slow acquisition of new intellectual information and skills in EOS patients during the first 5 years after full clinical presentation.

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Premorbid IQ in Schizophrenia: A Meta-Analytic Review

Abstract: Years before the onset of psychotic symptoms, individuals with schizophrenia, as a group, demonstrate mean IQ scores approximately one-half of a standard deviation below that of healthy comparison subjects.

Cited by 506 publications

References 38 publications

Rethinking the Concept of Psychosis and the Link Between Autism and Schizophrenia

Rethinking the Concept of Psychosis and the Link Between Autism and Schizophrenia

Review paper. Neuropsychological dimension of schizophrenia - evaluation possibilities and therapeutic implications

Course of intelligence deficits in early onset, first episode schizophrenia: a controlled, 5-year longitudinal study

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