Premorbid performance IQ deficit in schizophrenia

Amminger, G. Paul; Schlögelhofer, Monika; Lehner, Thomas; Ott, S. Looser; Friedrich, MH; Aschauer, Harald

doi:10.1034/j.1600-0447.2000.102006414.x

Cited by 33 publications

(22 citation statements)

References 17 publications

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“…Thus, although there is a negative link between FSIQ and psychotic disorders primarily low PIQ was strongly related to psychoses whereas this was not the case for VIQ. This finding in which subjects with psychotic illnesses perform more poorly on performance than on verbal intelligence tasks is consistent with earlier research showing that primarily fluid functions are negatively affected in psychotic individuals (Aylward et al, 1984;Ott et al, 1998;Amminger et al, 2000). This gap between deficits, however, is assumed to vary according to the stage of illness.…”

Section: Discussionsupporting

confidence: 79%

“…In another but prospective conscript study, a general cognitive impairment was found to be predictive of later disorders from the schizophrenia spectrum, however, an additional risk was given by deficits in nonverbal reasoning (comparable to PIQ) (Reichenberg et al, 2006). This effect might be explained by neurodegenerative processes in specific areas of the brain during illness which involve fluid components of intelligence such as executive functions and working memory (Purcell et al, 1998;Amminger et al, 2000;Ojeda et al, 2010). While basic functions are intact those functions which enable the acquisition of new information and skills are impaired (Bedwell et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

“…Indeed for in schizophrenia and other psychoses cognitive deficits are considered to be a core feature of the disease and are therefore well investigated (for an overview see Matheson et al, 2011). However, more recent prospective studies suggested cognitive impairments might have their origins several years prior to the psychotic break and are therefore not attributable to onset and course of the illness ( Rund, 1998;Amminger et al, 2000;van Winkel et al, 2006;Kremen et al, 2010;Mechelli et al, 2011). A meta-analysis of longitudinal population-based studies provided strong evidence for pre-morbid cognitive deficits in future cases of psychosis (Khandaker et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Precursors of cognitive impairments in psychotic disorders: A population-based study

Müller

Vetter

Weiser

et al. 2013

Psychiatry Research

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Cognitive deficits have been found to be more prevalent in psychotic than in other disorders. Longitudinal research has shown that these deficits were generally already existent before onset of illness and are therefore not necessarily attributable to neurodegenerative processes. This study investigated whether both low IQ and markers of premorbid cognitive dysfunction independently contribute to an increased risk for psychoses. In a cross-sectional study about 50,000 young Swiss males completed a survey of intellectual problems in childhood/adolescence and other vulnerability factors during military call-up in 2005/2006. Subsequently, military IQ assessments were carried out on the entire sample. Diagnostic assessments were conducted according to International Classification of Diseases-10th edition (ICD-10). Low, especially performance, IQ was highly associated with an increased risk for psychotic disorders after adjusting for preexisting cognitive deficits and covariates, while in other disorders this association was less marked. Furthermore, preexisting intellectual problems emerged as important risk factors for psychoses. Our results confirm the importance of low IQ as characteristic of psychoses. Although premorbid intellectual deficits are common in people who go on to develop psychosis, neurodegenerative disease processes may also precipitate further declines in fluid cognitive functions. Assessment of cognitive functioning should be taken into account in early detection of psychoses. Longitudinal research has shown that these deficits were generally already existent before onset of illness and are therefore not necessarily attributable to neurodegenerative processes. This study investigated whether both low IQ and markers of premorbid cognitive dysfunction independently contribute to an increased risk for psychoses. In a cross-sectional study about Subsequently, military IQ assessments were carried out on the entire sample. Diagnostic assessments were conducted according to ICD-10. Low, especially performance IQ was highly associated with an increased risk for psychotic disorders after adjusting for preexisting cognitive deficits and covariates; while in other disorders this association was less marked.Furthermore, preexisting intellectual problems emerged as important risk factors for psychoses.Our results confirm the importance of low IQ as characteristic of psychoses. Although premorbid intellectual deficits are common in people who go on to develop psychosis, neurodegenerative disease processes may also precipitate further declines in fluid cognitive functions. Assessment of cognitive functioning should be taken into account in early detection of psychoses.

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Precursors of cognitive impairments in psychotic disorders: A population-based study

Müller

Vetter

Weiser

et al. 2013

Psychiatry Research

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“…Verbal knowledge is less likely to deteriorate after brain insult (Nelson and O'Connell, 1978) and less affected before the onset of psychosis (Amminger et al, 2000). Therefore, reduced performance on verbal measures of general knowledge is indicative of lower premorbid cognitive function.…”

Section: Discussionmentioning

confidence: 99%

Common genetic risk variants are associated with positive symptoms and decision-making ability in patients with schizophrenia

Martin

Robinson

Reutens

et al. 2015

Psychiatry Research

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“…Amminger et al [7] found that subjects who later developed schizophrenia had lower intelligence quotient (IQ) scores, specifically on the Performance IQ Scale, than control individuals and those with affective disorder. Similarly, Cannon et al [8•] found that cognitive functioning in patients who were later diagnosed with schizophrenia, as well as their siblings, was stable from age 4 to 7 years, and more impaired than nonpsychiatric control individuals.…”

Section: Course Of Schizophreniamentioning

confidence: 99%

Cognition in schizophrenia

Harvey

Bowie

Friedman

2001

Curr Psychiatry Rep

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Cognitive dysfunction has been described as a hallmark feature of schizophrenia since the first descriptions of the illness. Kraepelin described a number of features of the disorder that he thought reflected impairments in cognition and attention. He also speculated that cognitive impairments were mediated by neurobiologic dysfunction, specifically impairments in the functions of the frontal lobe. Since Kraepelin's time, there have been many changes in the general conceptions of schizophrenia, including ideas regarding the status and importance of cognitive impairment in the illness. Due to increased sophistication of neuropsychologic assessment and neuroimaging techniques, cognitive impairment has again has risen to the forefront of importance in terms of theories regarding the etiology and treatment of schizophrenia.

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Premorbid performance IQ deficit in schizophrenia

Abstract: Our results emphasize premorbid intellectual deficits in schizophrenia. Those deficits might largely be in consequence of an impairment on the PIQ scale.

Cited by 33 publications

References 17 publications

Precursors of cognitive impairments in psychotic disorders: A population-based study

Precursors of cognitive impairments in psychotic disorders: A population-based study

Common genetic risk variants are associated with positive symptoms and decision-making ability in patients with schizophrenia

Cognition in schizophrenia

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