We investigated whether differences in positive and negative emotional reactivity could be found in depressed preschoolers and preschoolers at risk for later internalizing symptoms relative to nondepressed/low risk comparison groups. Observational measures of emotional reactivity, used to derive a score of the balance between anger and sadness, were obtained and analyzed in independent samples. One study utilized cross-sectional data from preschoolers with a current depressive syndrome and two non-depressed comparison groups. The other study utilized longitudinal data that assessed emotional reactivity at preschool age and later mental health symptoms during the transition to primary school, allowing a retrospective determination of risk. Depressed and at risk boys displayed more anger than sadness in contrast to girls in the same groups and in contrast to no disorder/ low risk controls. This finding was detected in depressed and "at risk for internalizing" boys who were not comorbid for externalizing problems. The validity of these findings, which are consistent with the developmental and theoretical literature, is enhanced by their emergence in two independent samples. Results suggest possible gender specificity in the manifestations of early onset depression.After a long history of skepticism about the possibility that children could experience clinical depression (Digdon & Gotlib, 1985;Rochlin, 1959), empirical data began to demonstrate that children and adolescents manifest symptoms of depression similar to those in the adult disorder as described in the Diagnostic and Statistical Manual (DSM; APA, 2000;Carlson & Cantwell, 1980; Puig-Antich, Blau, Marx, Greenhill, & Chamber, 1978;Ryan, Puig-Antich, & Ambrosini, 1987). Both longitudinal follow-up studies and findings of high genetic risk for affective disorders in adolescent and adult relatives of depressed child probands further emphasized the validity of depression as well as the continuity of the disorder over the lifespan (Todd, Neuman, Geller, Fox, & Hickok, 1993;Weissman et al., 1999). Studies also demonstrated that the presence of sadness and the absence of positive affective states, as evidenced by anhedonia, are primary characteristics of childhood depression (Carlson & Cantwell, 1980;Kovacs & Paulauskas, 1984). Furthermore, the unique importance of irritability or anger in childhood depression was also emphasized, leading to a developmental modification to the DSM criteria for Major Depressive Disorder (MDD) that stipulated that, in children, irritability rather than sadness can serve as a cardinal symptom of depression.In keeping with these findings in older children, Luby and colleagues (2002;2003a) have provided data suggesting that negative emotions characteristic of adult MDD, such as sadness and anhedonia, may also arise as early as age 3. A specific and stable constellation of depressive symptoms, with associated impairment in functioning rated by both parents and teachers, was identified in these young children when core DSM symptom...