Premorbid Predictors of Chronic Fatigue

Kato, Kenji; Sullivan, Patrick F.; Evengård, Birgitta; Pedersen, Nancy L.

doi:10.1001/archpsyc.63.11.1267

Cited by 129 publications

(119 citation statements)

References 31 publications

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“…33 In our multivariate analysis, high neuroticism had the greatest numerical point estimate of odds ratio, which indicates a particularly strong association with post-treatment CF, in agreement with observations in long-term testicular cancer survivors. 7 In general, neuroticism has only rarely been evaluated in connection with the treatment of prostate cancer.…”

Section: Discussionsupporting

confidence: 89%

Fatigue in hormone-naïve prostate cancer patients treated with radical prostatectomy or definitive radiotherapy

Kyrdalen

Dahl

Hernes

et al. 2010

Prostate Cancer Prostatic Dis

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Chronic fatigue (CF) is a distressing symptom that follows cancer treatment; however, it has rarely been studied in hormone-naïve prostate cancer survivors after radical prostatectomy (RP) or definitive radiotherapy (RAD). We investigated CF in prostate cancer survivors after RP or RAD as monotherapy and explored associations between CF and medical and psychosocial variables. A population-based, cross-sectional postal survey in 2006 included Norwegian hormone-naïve survivors with the diagnosis of prostate cancer in 2004 who were treated with RP (n ¼ 337) or RAD (n ¼ 184). The primary outcome variable was prevalence of CF (defined as fatigue lasting 6 months or longer). Twelve to 32 months after RP and RAD, 13.4 and 26.1% of the patients after, respectively, RP and RAD reported CF inversely associated with pretreatment age (P ¼ 0.003). In multivariate analysis, high neuroticism, post-treatment co-morbidity, pain, urinary and intestinal dysfunction, but not sexual dysfunction, were positively associated with reporting CF. Further studies of CF in prostate cancer survivors should take into consideration the survivors' pretreatment medical and psychosocial situation.

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Section: Discussionsupporting

confidence: 89%

Fatigue in hormone-naïve prostate cancer patients treated with radical prostatectomy or definitive radiotherapy

Kyrdalen

Dahl

Hernes

et al. 2010

Prostate Cancer Prostatic Dis

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“…Within this account, cognitive behavioural models have become increasingly popular [2][3][4][5]. These models propose a set of predisposing factors (e.g., genetics, personality characteristics, and life events), precipitating factors (e.g., physiological factors and general distress) and perpetuating factors (e.g., physiological, cognitive, behavioural, and social reactions) that each may contribute to the development and maintenance of CFS [3][4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

“…In particular the trait 'neuroticism', which is characterized as the degree of emotional instability, associated with a tendency to experience negative emotions, a vulnerability for stress and for psychopathology, may be relevant [33]. First, neuroticism is presumed to be one of the predisposing factors of CFS in [4][5]34] in biopsychosocial accounts. Second, there is preliminary evidence that neuroticism negatively influences illness acceptance and mental wellbeing in CFS [31].…”

Section: Introductionmentioning

confidence: 99%

Cognitive behavior therapy in patients with chronic fatigue syndrome: The role of illness acceptance and neuroticism

Poppe

Petrovic

Vogelaers

et al. 2013

Journal of Psychosomatic Research

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Number of words: 4560 Number of tables: 3Running head: CBT and chronic fatigue syndrome Key Words: chronic fatigue syndrome, cognitive behaviour therapy, acceptance, healthrelated quality of life, neuroticism. 2 AbstractObjective. Increasing the quality of life (QoL) of patients with chronic fatigue is challenging because recovery is seldom achieved. Therefore, it is important to identify processes that improve QoL. This study examined the extent of improvement related to cognitive behaviour group therapy (CBT), and whether improvement is affected by initial levels of acceptance and neuroticism.Methods. Eighty CFS patients followed CBT, and self-reported (pre-post design) on mental and physical QoL (MQoL and PQoL), fatigue, acceptance, neuroticism. The extent of improvement was analyzed using t-tests, effect sizes, and clinically significant change criteria.Whether acceptance and neuroticism at baseline predicted changes, was analyzed by means of correlation and regression analyses. Results. Significant improvement was found for all variables. The effect size for MQoL andPQoL was small; for acceptance and fatigue moderate. About 20% (MQoL) to 40% (fatigue) of the participants clinically improved.Pre-treatment level of acceptance was negatively correlated with changes in MQoL, not with PQoL changes. Neuroticism pre-treatment was positively related with MQoL changes.Regression analysis showed an effect of acceptance on changes in MQoL beyond the effect of neuroticism. Conclusions:Although CBT is an evidence-based treatment, the sizes of the effects are often small regarding QoL. Our study also revealed small effect sizes. Our study showed that patient characteristics at baseline were significantly associated with MQoL outcome; indicating that CFS patients with high neuroticism or with a low acceptance show more improvement in MQoL. We propose to specifically target acceptance and neuroticism before treatment in order to maximize clinical relevance.3

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“…While the exclusion of medical causes of symptoms is important, there are a range of factors that should heighten a clinician's awareness of the possibility of FSS. These can be pre-morbid factors known to be risk factors of FSS, such as being female [2], having prior psychiatric disorders [9,20,21], prior experience of illness in the family and previous unexplained symptoms in the individual [22,23], levels of social adjustment [24] or, as highlighted by Kempke et al's article in this issue, certain personality styles [25], although it is fair to say that evidence on the role of personality and personality disorder is conflicting [24]. Additionally, factors around the way in which an individual describes their symptoms or examination findings may be positive signs of a functional disorder [26].…”

mentioning

confidence: 99%