Prenatal abnormal width of the cavum septum pellucidum – MRI features and neurodevelopmental outcome

Cooper, Shiri; Katorza, E.; Berkenstadt, Michal; Hoffmann, Chen; Achiron, R.; Bar‐Yosef, Omer

doi:10.1080/14767058.2017.1364721

Cited by 14 publications

(13 citation statements)

References 26 publications

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“…The likely explanation being the capacity for plasticity in the early CNS, which allows for a range of normal or mildly abnormal outcomes despite malformations or insults. Evidence for this has emerged from studies that contain neurodevelopmental outcomes after several years of follow up, and which demonstrate a high proportion of neurologically normal outcomes despite structural malformations 22–25. Thus a longer period of follow up in the present study may allow for brain maturation and emergence of the likely long-term neurodevelopmental status for these subjects against which in utero GM assessment could be assessed.…”

Section: Discussionmentioning

confidence: 79%

Neurodevelopmental Correlates of Fetal Motor Behavior Assessed Using Cine MR Imaging

Hayat

Martinez‐Biarge

Kyriakopoulou

et al. 2018

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:Fetal motor behavior is widely used as a clinical indicator for healthy development; however, our understanding of its potential as a marker for neurologic integrity is underdeveloped. MR imaging allows complete views of the whole fetus, which, combined with brain imaging, may improve the characterization of this relationship. This study aimed to combine an analysis of fetal motor behavior, brain MR imaging, and postnatal outcome, to provide insight into neurodevelopmental correlates of motor behavior.

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Section: Discussionmentioning

confidence: 79%

Neurodevelopmental Correlates of Fetal Motor Behavior Assessed Using Cine MR Imaging

Hayat

Martinez‐Biarge

Kyriakopoulou

et al. 2018

AJNR Am J Neuroradiol

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“…The cavum septum pellucidum (CSP) is a fluid‐filled cavity found between the leaves of the septum pellucidum in the fetus . Enlarged CSP has often been considered a marker for fetal neural maldevelopment affecting the septo‐hippocampal and limbic systems, and a maker for aneuploidy .…”

Section: Discussionmentioning

confidence: 99%

“…8 The cavum septum pellucidum (CSP) is a fluidfilled cavity found between the leaves of the septum pellucidum in the fetus. 12 Enlarged CSP has often been considered a marker for fetal neural maldevelopment affecting the septo-hippocampal and limbic systems, 13 and a maker for aneuploidy. 7 Several investigations have shown that a wide (>1 cm) CSP and persistence of a CSP beyond infancy served as significant markers of cerebral dysfunction and may be accompanied by a significantly increased risk of mental retardation, developmental delay and neuropsychiatric disturbances.…”

Section: Discussionmentioning

confidence: 99%

The ratio of cavum septi pellucidi width to anteroposterior cerebellar diameter: A novel index as a diagnostic adjunct for prenatal diagnosis of trisomy 18

Xie

et al. 2019

J of Obstet and Gynaecol

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Aim To explore the effectiveness of cavum septi pellucidi (CSP) width to anteroposterior cerebellar diameter (APCD) ratio as a diagnostic adjunct for prenatal diagnosis of trisomy 18. Methods Images of normal fetal brain within 15 and 35 weeks were stored in our center from 2016 to 2017. Images of aneuploid fetuses were retrospectively collected from 2004 to 2017. The transverse cerebellar diameter, APCD and CSP width were measured. CSP/APCD and APCD/transverse cerebellar diameter ratios were calculated and compared between euploid and aneuploid fetuses. Results One thousand and forty one fetuses were analyzed, including 817 euploid fetuses and 224 aneuploid fetuses (trisomy 21 117 cases, trisomy 18 82 cases, trisomy 13 9 cases, sex‐linked 16 cases). No correlation had been found between both ratios and gestational weeks (P > 0.05). In aneuploid groups, means of ratios were both significantly different just between trisomy 18 group and euploid group (P < 0.05). The best area under the curve was shown by the CSP/APCD ratio. The cutoff value of CSP/APCD was 0.46 (sensitivity 87.0%, specificity 85.0%). Conclusion A wide CSP or cerebellar hypoplasia warrants a more detailed ultrasound screening and genetic counseling. A larger CSP/APCD ratio alerts us to trisomy 18 syndrome, especially in cases with subtle anomalies.

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“…Mild ventriculomegaly (ventricle width of 10–12 mm) without other systemic malformations is usually considered to have normal neurodevelopmental processes [ 16 ]. Without of aneuploidy and other associated fetal abnormalities, the neurodevelopment appears to be normal in the abnormal width of the CSP prenatally [ 17 ]. Because of the prognosis, these fetuses were considered to be low risk and selected in the study.…”

Section: Methodsmentioning

confidence: 99%

Fetal magnetic resonance imaging of lumbar spine development in vivo: a retrospective study

Yin

Xin

et al. 2022

Childs Nerv Syst

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Objective The aim of this study is to describe MR imaging appearances of the fetal lumbar spine in vivo at different gestational ages (GAs). Methods This retrospective study was approved by the Third Affiliated Hospital of Zhengzhou University. We collected MR images and clinical data of 93 fetuses in our hospital. All the MR images were obtained by 3-T MR. All had the mid-sagittal plane of steady state free precession sequence (Trufi) of the lumbar spine, which could show the lumbar vertebra and conus medullaris (CM). Regression analysis was made between GA and heights of lumbar vertebral body ossification center (LVBOC), lengths of LVBOC, and heights of intervertebral gap (IVG). Results There were good linear correlations between the heights of LVBOC and GA (P < 0.001), lengths of LVBOC and GA (P < 0.001), and heights of IVG and GA (P < 0.001). Conclusion We showed the different development of each LVBOC and IVG which caused the difference of the shape of LVBOC and IVG.

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Prenatal abnormal width of the cavum septum pellucidum – MRI features and neurodevelopmental outcome

Cited by 14 publications

References 26 publications

Neurodevelopmental Correlates of Fetal Motor Behavior Assessed Using Cine MR Imaging

Neurodevelopmental Correlates of Fetal Motor Behavior Assessed Using Cine MR Imaging

The ratio of cavum septi pellucidi width to anteroposterior cerebellar diameter: A novel index as a diagnostic adjunct for prenatal diagnosis of trisomy 18

Fetal magnetic resonance imaging of lumbar spine development in vivo: a retrospective study

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