Prenatal and childhood exposure to phthalates and motor skills at age 11 years

Balalian, Arin A.; Whyatt, Robin M.; Liu, Xinhua; Insel, Beverly J.; Rauh, Virginia; Herbstman, Julie B.; Factor-Litvak, Pam

doi:10.1016/j.envres.2019.01.046

Cited by 37 publications

(26 citation statements)

References 85 publications

(132 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a recent study, evaluating phthalate exposure during pregnancy and several times in childhood period, higher prenatal exposure to specific phthalates was associated with lower motor function among 11-year old girls while higher postnatal exposure to DEHP metabolites was associated with lower scores among boys (Balalian et al, 2019). The negative impact of prenatal exposure to several phthalates on child motor functions at age of 2 years was observed in our previous analysis (based on a subsample of the REPRO_PL cohort) (Polańska et al, 2014).…”

Section: Discussionmentioning

confidence: 98%

Prenatal and early postnatal phthalate exposure and child neurodevelopment at age of 7 years – Polish Mother and Child Cohort

Jankowska

Polańska

Hanke

et al. 2019

Environmental Research

View full text Add to dashboard Cite

Phthalates are among of the most frequently investigated environmental chemicals influencing children's health and particularly their neuropsychological development. However, the reported effects of these compounds on child behavior, cognitive and psychomotor outcome are not fully consistent. The aim of this study is to evaluate the associations between prenatal and early postnatal phthalate exposures and child neurodevelopment at age of 7 years. A total of 134 mother-child pairs from Polish Mother and Child cohort (REPRO_PL) constitute the basis for current analysis. Eleven phthalate metabolites were measured in urine samples collected from mothers in the 3 rd trimester of pregnancy and from children at the age of 2 years. Child neuropsychological development at early school age (7 years) was assessed by both the Strengths and Difficulties Questionnaire (SDQ) filled by mothers and the Polish adaptation of the Intelligence and Development Scales (IDS) performed by psychologists. MEP concentration during pregnancy was significantly associated with increased risk of peer relationship problems in SDQ (OR=2.7, p=0.03). The concentration of two phthalate metabolites (oxo-MEHP and MiBP) in the urine collected from mothers during pregnancy, as well as MnBP concentration at age of 2 years were of borderline significance on prosocial behaviour and hyperactivity/inattention problems, respectively (OR=2.6, p=0.08; OR=2.2, p=0.07; OR=2.6, p=0.08). The results of the IDS analyses focused on child's cognitive and psychomotor development are not fully conclusive. Negative associations were evident between some phthalates in early childhood period and fluid intelligence and cognition (MEP: β=-5.2; p=0.006; β=-4.2; p=0.006; MnBP: β=-4.9; p=0.03; β=-4.0; p=0.03; respectively) and psychomotor skills (OH-MiNP: β=-1.2; p=0.07), while positive associations have been found in the prenatal period (MEP: β=2.9; p=0.07 for cognition; β=1.4; p=0.06 for language skills; oxo-MEHP: β=3.6; p=0.03 for fluid intelligence; β=2.9; p=0.03 for cognition; β=1.2; p=0.08 for psychomotor development). Further studies are required in order to elucidate which are the most critical periods of phthalate exposure on children's neurodevelopmental outcomes.

show abstract

Section: Discussionmentioning

confidence: 98%

Prenatal and early postnatal phthalate exposure and child neurodevelopment at age of 7 years – Polish Mother and Child Cohort

Jankowska

Polańska

Hanke

et al. 2019

Environmental Research

View full text Add to dashboard Cite

show abstract

“…Phthalates cross the placental barrier. Exposure during gestation adversely affects juvenile neurodevelopment (Balalian et al, 2019). Phthalates may alter cerebral neural growth and differentiation and have negative neurocognitive and behavioral effects (Owens, 2015).…”

Section: Suggested Effects Of Phthalates On Health As Endocrine Disrumentioning

confidence: 99%

Di-(2-ethylhexyl) Phthalate (DEHP) and Uterine Histological Characteristics

Cheon¹

2020

Dev. Reprod.

View full text Add to dashboard Cite

Phthalates have a long industrial history. It is suspected that phthalates and their metabolites have detrimental effects on reproduction and development. They are well-known for their anti-androgenic effects. Several studies have indicated that phthalates and their metabolites are reprotoxic in males and endocrine disruptors. Reproduction and embryogenesis occur in the uterus of female eutherian mammals. A horizontal analytical method is preferred to elucidate the toxic effects of phthalates on human reproduction. Nevertheless, there are vast numbers of known phthalates and not all of their modes of action have been clarified. Di-(2-ethylhexyl) phthalate (DEHP) is a commonly used plasticizer and has been the subject of numerous toxicological studies. However, few of these have reported on the toxic effects of DEHP, its metabolites, other phthalates, or mixtures on female reproduction. Acute and high doses of DEHP adversely affect uterine histology. Recently, it was disclosed that chronic exposures to low doses of DEHP have endocrine disruption efficacy. DEHP induces various cellular responses including modulation of the expression and regulation of steroid hormone receptors and transcription and paracrine factors. Uteri do not respond uniformly to DEHP exposure. The phenotypic manifestations and effects on fertility in response to DEHP and its metabolites may vary with species, developmental stage, and generation. Hence, DEHP exposure may histological alter the uterus and induce endometriosis, endometriosis, hyperplasia, myoma, and developmental and reproductive toxicity.

show abstract

“…Higher pre-birth presentation to explicit phthalates was related with lower engine work among 11-year old young ladies while higher postnatal introduction to DEHP metabolites was related with lower scores among young men. As lower scores on proportions of engine improvement have been related with more issues in intellectual, motional feelings working and conduct, the discoveries have suggestions identified with in general kid advancement (Balalian et al, 2019). Taiwan's pork and chicken are satisfactory in quality and are adequately protected.…”

Section: Mammalsmentioning

confidence: 99%

Consequences of Exposure to Phthalates, Micro Plastics and Nano-Plastics on the Organisms

Simran¹,

Singh²

2021

PLANT ARCHIVES

View full text Add to dashboard Cite

Study of Microplastice, Polystyrene and phthalates (BPA, DBP, and DEHP) is as popular as scientists use them as a key point to reach up the new approaches. Toxicity of Phthalates and plastic components come through various sources that we are using in our daily life and it results in hazardous impacts on vertebrates and non-vertebrates organisms. Previous researches on the effect of these components have been done by using the model organisms. This review paper contains the information of past studies regarding toxicity of Microplastic and phthalates in vertebrates like mammals (human beings and whale), aquatic organisms, Zebra fish (Danio rerio) and invertebrates including D. melanogaster, D. pulex and D. magna. Ingestion of phthalates and plastic components in organisms takes place due to the contaminated water and food. Many research papers studies have explained that, those 44 organisms (weather aquatic or terrestrial) who consume plastic and phthalates through their contaminated food with different concentrations always suffer from some morphological, behavioral, biochemical and reproductive deformities. Ingestion of these components into the organisms contains a proper cycle of food web. Each and every organism hasa direct or indirect impact of Micro plastic and phthalates. Some scientists also explained that how a pregnant woman can be responsible for the disease in fetus and infants after consumption of these compounds. Male and female have different types of toxicity in their body functions including hormonal disturbance. So, plastic and phthalates have adverse consequences on aquatic life and human health

show abstract

Prenatal and childhood exposure to phthalates and motor skills at age 11 years

Cited by 37 publications

References 85 publications

Prenatal and early postnatal phthalate exposure and child neurodevelopment at age of 7 years – Polish Mother and Child Cohort

Prenatal and early postnatal phthalate exposure and child neurodevelopment at age of 7 years – Polish Mother and Child Cohort

Di-(2-ethylhexyl) Phthalate (DEHP) and Uterine Histological Characteristics

Consequences of Exposure to Phthalates, Micro Plastics and Nano-Plastics on the Organisms

Contact Info

Product

Resources

About