Prenatal and Childhood Smoke Exposure Associations with Cognition, Language, and Attention-Deficit/Hyperactivity Disorder

Fuemmeler, Bernard F.; Glasgow, Trevin E.; Schechter, Julia C.; Maguire, Rachel; Sheng, Yaou; Bidopia, Tatyana; Barsell, D. Jeremy; Ksinan, Albert J.; Zhang, Junfeng; Yang, Lin; Hoyo, Cathrine; Murphy, Susan K.; Qin, Jian; Wang, Xiangtian; Kollins, Scott H.

doi:10.1016/j.jpeds.2022.11.041

Cited by 5 publications

(2 citation statements)

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“…The China Health and Retirement Longitudinal Study (CHARLS) has shown that secondhand smoke exposure significantly reduced visual-spatial ability and situational memory function among elderly females 34 . Childhood tobacco smoke exposure has been linked to the impaired development of the cerebral cortex, frontal lobe, parietal lobe and temporal lobe 26 , resulting in poor attention, language acquisition and visual processing ability 25 . Animal experiments have shown that attention cognitive impairment caused by prenatal nicotine exposure can be improved by galantamine in mice 35 .…”

Section: Discussionmentioning

confidence: 99%

“…The developmental neurotoxicity of nicotine may disrupt the balance of cholinergic transmission, and prenatal exposure to nicotine severely affects the neurodevelopment, cognition, and behavioral production of offspring [22][23][24] . Childhood tobacco smoke exposure can have sustained negative effects on cognitive function and brain structure 25,26 , and even affect cognitive ability in middle age 27 . Aging-related environmental tobacco smoke exposure is associated with poorer cognitive performance 28,29 .…”

Section: Discussionmentioning

confidence: 99%

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Urinary nicotine metabolites are associated with cognitive impairment among the elderly in southern China

Huang,

Ren,

et al. 2023

Tob. Induc. Dis.

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INTRODUCTION This study comprehensively assessed the association between eight metabolites of urinary nicotine and cognitive impairment. METHODS This cross-sectional study was based on the data of Shenzhen Aging Related Disorder Cohort (SADC), including 51 elderly community data variables such as demographic characteristics, neuropsychological assessment and environmental factors, from July 2017 to November 2018. Participant’s cognitive function was assessed by Mini-Mental State Examination (MMSE) scale and urinary nicotine metabolite [including cotinine N-β-D-glucuronide (CotGluc), rac 4-hydroxy-4-(3-pyridyl) butanoic acid dicyclohexylamine salt (HyPyBut), trans-3’-hydroxy cotinine O-β-D-glucuronide (OHCotGluc), and cotinine (Cot), etc.] concentrations were measured by high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS). Generalized linear models and restricted cubic spline models were used to explore the relationships between the urinary levels of nicotine metabolite and cognitive function. RESULTS A total of 296 individuals aged >60 years were included. Individuals in the third quartile of CotGluc had a 0.786 point (95% CI: -1.244 – -0.329) decrease or in the highest quartile of OHCotGluc had a 0.804 point (95% CI: -1.330 – -0.278) decreased in attention and calculation compared to those in the lowest quartile (all p for trend <0.05). Compared with those in the lowest quartile, individuals in the highest quartile of CotGluc, HyPyBut, OHCotGluc and Cot, respectively, corresponded to a 1.043 point (95% CI: -2.269–0.182), 1.101 points (95% CI: -2.391–0.188), 2.318 points (95% CI: -3.615 – -1.020), and 1.460 points (95% CI: -2.726 – -0.194) decreased in MMSE total score (all p for trend <0.05). A non-linear dose-response relationship between urinary levels of CotGluc, HyPyBut, OHCotGluc or Cot and cognitive function (all overall p<0.05, non-linear p<0.05). Subgroup analysis showed that urinary levels of CotGluc, OHCotGluc or Cot were significantly negatively associated with cognitive function (all p for trend <0.05) among females and non-smokers. CONCLUSIONS The findings highlight the public health implications of environmental tobacco smoke exposure, and effective interventions need to be performed for vulnerable populations.

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