Prenatal and Perinatal Risk Factors for Autism in China

Zhang, Xin; Lv, Cong Chao; Tian, Jingjing; Miao, Ru Juan; Wei, Xi; Hertz‐Picciotto, Irva; Qi, Lihong

doi:10.1007/s10803-010-0992-0

Cited by 155 publications

(162 citation statements)

References 63 publications

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“…Varying reports have also implicated measles and mumps (Deykin and MacMahon, 1979), cytomegalovirus (Libbey et al, 2005), polyomaviruses (Lintas et al, 2010), and influenza (Atladottir et al, 2012;Deykin and MacMahon, 1979;Shi et al, 2003;Zhang et al, 2010) in the incidence of ASD. Some studies suggest fever as a correlate (Atladottir et al, 2012), with this risk potentially tempered by anti-fever medications, such as Advil, Tylenol, or Nyquil (Zerbo et al, 2013).…”

Section: Congenital Infectionmentioning

confidence: 99%

“…Given the diversity of infections that show a connection to the spectrum of autism disorders (Boksa, 2010;Libbey et al, 2005), as well as evidence from MIA models that reaction to infection rather than infection itself may lead to autismrelated symptoms (Shi et al, 2003), a possible common etiology may be the influence of the immune system (Gottfried et al, 2015;Lintas et al, 2010;Zhang et al, 2010). Cytokines, small cell-signaling proteins that act as immunomodulatory and endocrine messengers, have been implicated throughout the process of CNS development (Boulanger, 2009;Jones and Thomsen, 2013).…”

Section: Cytokinesmentioning

confidence: 99%

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The Role of the Immune System in Autism Spectrum Disorder

Meltzer

Water

2016

Neuropsychopharmacol

405

293

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Autism is a neurodevelopmental disorder characterized by deficits in communication and social skills as well as repetitive and stereotypical behaviors. While much effort has focused on the identification of genes associated with autism, research emerging within the past two decades suggests that immune dysfunction is a viable risk factor contributing to the neurodevelopmental deficits observed in autism spectrum disorders (ASD). Further, it is the heterogeneity within this disorder that has brought to light much of the current thinking regarding the subphenotypes within ASD and how the immune system is associated with these distinctions. This review will focus on the two main axes of immune involvement in ASD, namely dysfunction in the prenatal and postnatal periods. During gestation, prenatal insults including maternal infection and subsequent immunological activation may increase the risk of autism in the child. Similarly, the presence of maternally derived anti-brain autoantibodies found in~20% of mothers whose children are at risk for developing autism has defined an additional subphenotype of ASD. The postnatal environment, on the other hand, is characterized by related but distinct profiles of immune dysregulation, inflammation, and endogenous autoantibodies that all persist within the affected individual. Further definition of the role of immune dysregulation in ASD thus necessitates a deeper understanding of the interaction between both maternal and child immune systems, and the role they have in diagnosis and treatment.

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Section: Congenital Infectionmentioning

confidence: 99%

Section: Cytokinesmentioning

confidence: 99%

The Role of the Immune System in Autism Spectrum Disorder

Meltzer

Water

2016

Neuropsychopharmacol

405

293

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“…106,109,139,140 Two 141,142 of three cohort studies [141][142][143] found a significant association between either prepregnancy weight, pregnancy weight gain or early-life obesity and ASD. A 2009 metaanalysis found a positive association between maternal gestational diabetes and ASD.…”

Section: Parental Agementioning

confidence: 99%

“…157 However, a more recent systematic review 13 indicated mixed findings. Since then, three [158][159][160] of five studies 106,109,[158][159][160] have found a significant association between low birth weight and ASD. In most studies, the low birth weight threshold was 2500 g.…”

Section: Pregnancy Complicationsmentioning

confidence: 99%

Environmental factors associated with autism spectrum disorder: a scoping review for the years 2003–2013

Montigny

Ofner

et al. 2017

Health Promot Chronic Dis Prev Can

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Introduction: The number of children diagnosed with autism spectrum disorder (ASD) has been rapidly rising in the past decade. The etiology of this disorder, however, is largely unknown, although the environmental relative to the genetic contribution is substantial. We conducted a scoping review to comprehensively assess the current state of knowledge of the environmental factors present from preconception to early life associated with ASD, and to identify research gaps.

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“…Dealberto also emphasizes the additional risk of autism to offspring of veiled women. Similarly, Zhang et al have described a "maternal unhappy emotional state" as a risk factor for autism [90]. James has suggested that the association between maternal migration, the accompanying stress, and autism is mediated by high maternal adrenal androgen concentrations [91].…”

Section: Environmental Factorsmentioning

confidence: 99%

Autism-A Multifaceted Diffuse Pathology

Brejlova¹,

Domkarova²,

Stefano³

2015

J Psychiatry

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Journal of Psychiatry AbstractThe causes of pervasive developmental disorders have yet to be resolved. Needless to say, the etiology is complex as are the individual factors, especially in regard to autism. Certain findings may be integrated into early coherent models, but the heterogeneity of findings remains a central feature of autism. The present review examines contemporary areas of research and a few prominent theories specifically dealing with autism. The areas under scrutiny are divided into common academic compartments, such as biological, environmental. Autism represents a very timely topic due to its rising incidence in the population as well as changes in previous concepts occurring at this time. Besides the neurological, biological and epidemiological factors contributing and possibly initiating this disorder we discuss the possible involvement of endogenous morphine, especially in regard to depression and limbic functions. Lastly, we advance the theory that dysfunctional mitochondria appear to be involved in autism as well, explaining the widespread occurrence of its characteristics within the construct of susceptibility to stress and trauma. Thus, the diffuse manifestations of Pervasive Developmental Disorder occur potentially by altering energy processes.

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Prenatal and Perinatal Risk Factors for Autism in China

Cited by 155 publications

References 63 publications

The Role of the Immune System in Autism Spectrum Disorder

The Role of the Immune System in Autism Spectrum Disorder

Environmental factors associated with autism spectrum disorder: a scoping review for the years 2003–2013

Autism-A Multifaceted Diffuse Pathology

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