Prenatal and postnatal probiotics reduces maternal but not childhood allergic diseases: a randomized, double‐blind, placebo‐controlled trial

Ou, Chia-Yu; Kuo, Ho‐Chang; Wang, L.; Hsu, Te‐Yao; Chuang, Hai‐Hua; Liu, C.‐A.; Chang, Jen-Chieh; Yu, Hong‐Ren; Yang, Kuender D.

doi:10.1111/j.1365-2222.2012.04037.x

Cited by 83 publications

(100 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…22 Asthma/wheeze was only reported by parents using a questionnaire, 18,20,25,27,36,37 and in 5 studies, verified by a physician, nurse, or asthma medication record. 16,19,22,24,26 A few studies used the same populations, Kalliomäki et al included a cohort of 159 mothers recruited in Finland in 3 studies 20,28,38 ; 3 studies 26,29,30 studied a cohort of 231 atopic pregnant women delivering in Australia; and Wickens et al focused on 223 Kiwi pregnant women where they or the infant' s father were atopic in 2 studies. 27,31 However, these cohorts were included only once in the different analyses (the most recent report in each case).…”

Section: Resultsmentioning

confidence: 99%

“…Excluded studies are listed in Supplemental Table 2. 31 Probiotics were administered prenatally (to pregnant mothers) in 2 trials, 18,24 prenatally to pregnant mothers and postnatally directly to children in 10 trials, 16,17,[19][20][21][22][23]26,39,40 and only postnatally to children in 9 studies. 25 31 Rautava et al, 39 and Gore et al 36 used separate Lactobacillus and Bifidobacterium arms compared with 1 placebo group.…”

Section: Resultsmentioning

confidence: 99%

“…[16][17][18][19][20][23][24][25][26][27]39,40 One tested only for food allergens 21 and another only for inhalant allergens. 22 Asthma/wheeze was only reported by parents using a questionnaire, 18,20,25,27,36,37 and in 5 studies, verified by a physician, nurse, or asthma medication record.…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Probiotic Administration in Early Life, Atopy, and Asthma: A Meta-analysis of Clinical Trials

Elazab

Mendy

Gasana³

et al. 2013

Pediatrics

234

174

View full text Add to dashboard Cite

WHAT'S KNOWN ON THIS SUBJECT:The intestinal microbiome may play a role in immune system maturation, and it has been postulated that early-life probiotic administration may reduce the risk of allergies and asthma in childhood. To date, however, results from clinical trials have been inconsistent. WHAT THIS STUDY ADDS:In this meta-analysis, administration of probiotics in early life may reduce total immunoglobulin E level and protect against atopic sensitization but do not seem to protect against asthma/wheezing. Future trials should carefully select probiotic strains and include longer follow-up. abstract BACKGROUND AND OBJECTIVE: Probiotics may reduce the risk of atopy and asthma in children. However, results from clinical trials have been conflicting, and several of them may have been underpowered. We performed a meta-analysis of randomized, placebo-controlled trials to assess the effects of probiotic supplementation on atopic sensitization and asthma/wheeze prevention in children. METHODS:Random-effects models were used to calculate pooled risk estimates. Meta-regression was conducted to examine the effect of potential factors on probiotics efficacy.RESULTS: Probiotics were effective in reducing total immunoglobulin E (IgE) (mean reduction: -7.59 U/mL [95% confidence interval (CI): -14.96 to -0.22]; P = .044). Meta-regression showed that the reduction in IgE was more pronounced with longer follow-up. Probiotics significantly reduced the risk of atopic sensitization when administered prenatally (relative risk: 0.88 [95% CI: 0.78 to 0.99]; P = .035 for positive result on the skin prick test and/or elevated specific IgE to common allergens) and postnatally (relative risk: 0.86 [95% CI: 0.75 to 0.98]; P = .027 for positive result on skin prick test). Administration of Lactobacillus acidophilus, compared with other strains, was associated with an increased risk of atopic sensitization (P = .002). Probiotics did not significantly reduce asthma/wheeze (relative risk: 0.96 [95% CI: 0.85 to 1.07]).CONCLUSIONS: Prenatal and/or early-life probiotic administration reduces the risk of atopic sensitization and decreases the total IgE level in children but may not reduce the risk of asthma/wheeze. Follow-up duration and strain significantly modified these effects. Future trials for asthma prevention should carefully select probiotic strain and consider longer follow-up. Pediatrics 2013;132:e666-e676 AUTHORS:

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Probiotic Administration in Early Life, Atopy, and Asthma: A Meta-analysis of Clinical Trials

Elazab

Mendy

Gasana³

et al. 2013

Pediatrics

234

174

View full text Add to dashboard Cite

show abstract

“…Consistently, a recent RDBPC trial using the same Lactobacillus GG single strain starting at the second trimester of pregnancy did not find differences in the incidence of sensitization to food allergens (sIgE) in the offspring of actively treated mothers compared to the placebo group [82].…”

Section: Clinical Studiesmentioning

confidence: 53%

“…Ou et al [82] pregnant women with personal history of allergic disease Lactobacillus GG 24 w.gestation/until delivery RDPPC Reduced severity of maternal allergic disease but not the incidence of childhood allergic disease. Table 3: Clinical studies assessing the preventive effect of probiotic intake during pregnany/lactation in children's food allergy [95].…”

Section: Chinese Herbs Food Allergy Herbal Formula-2mentioning

confidence: 99%

The Potential of Maternal Dietary Modification for Prevention of Food Allergy

Luengo¹,

Song²

2013

J Aller Ther

View full text Add to dashboard Cite

Effective primary preventions strategies aimed at reducing the onset of IgE sensitization are urgently needed as the incidence of childhood food allergy keeps increasing.Studies eliminating food allergens during pregnancy have failed to show reduction in the prevalence of long-term IgE-mediated food allergy in children, and recent data provides direct evidence supporting early oral exposure as a means of preventing development of allergy. Since effects on early immune programming may be more significant in utero, there has been increasing interest in the potential protective role of maternal dietary modifications on the development of FA in offspring.In this article, we will review the current knowledge from animal and clinical studies on the role of maternal dietary modification, mainly through supplementation with vitamins, polyunsaturated fatty acids and probiotics, for the prevention of food allergy. Besides, the potential role of some promising FA treatments like Chinese herbal formula FAHF-2 for the primary prevention of FA in offspring will be reviewed. be due to uncontrolled environmental factors, timing of introduction to PN and different study protocols and populations, as well as undefined co-factors in maternal diet such as microbes [18][19][20]. In addition, retrospective maternal recall of dietary intake during pregnancy (and or lactation), sometimes months or years later, may contain recall bias. At present, the standard practice for PNA and other food allergies is strict allergen avoidance. There is no clinical study reporting whether peanut allergic mother consumption of controlled low doses of peanut that do not trigger clinical reactions would prevent offspring peanut or other food allergies. The Potential of Maternal Dietary Modification for Prevention of Food AllergyOlga Maternal allergenic food consumption for preventing food allergy in offspring: Animal studiesIn recent years several studies in animal models have provided direct evidence supporting early oral exposure as a means of preventing development of allergy.Melkild et al. [21] showed that intraperitoneal immunization of naïve mice with ovalbumin and adjuvant (Al(OH) 3 ) during pregnancy and lactation significantly reduced the specific IgE response and increased the IgG2a response in their offspring. Moreover, the IgE suppression was stronger if maternal allergen exposure was during early pregnancy (3 days into pregnancy) compared to a late pregnancy exposure (17 days into pregnancy). The same group reported that the protective effect of maternal immunization was affected by the type of adjuvant used: while offspring from mothers immunized with OVA and either pertussis toxin (PT) or Al(OH) 3 showed reduced levels of OVA-specific IgE and IgG1 and increased levels of OVA-specific IgG2a antibodies, maternal immunization with CpG and OVA did not affect antibody responses in offspring [22]. However, whether this effect is dependent on the specific adjuvant and/or the route of exposure employed has to be further investigated. Le...

show abstract

Probiotics for treating eczema

Makrgeorgou¹,

Leonardi‐Bee

Bath‐Hextall

et al. 2018

Cochrane Database of Systematic Reviews

View full text Add to dashboard Cite

show abstract

Prenatal and postnatal probiotics reduces maternal but not childhood allergic diseases: a randomized, double‐blind, placebo‐controlled trial

Abstract: LGG administration beginning at the second trimester of pregnancy reduced the severity of maternal allergic disease through increment of Th1 response, but not the incidence of childhood allergic sensitization or allergic diseases (ClinicalTrials.govnumber, IDNCT00325273).

Cited by 83 publications

References 40 publications

Probiotic Administration in Early Life, Atopy, and Asthma: A Meta-analysis of Clinical Trials

Probiotic Administration in Early Life, Atopy, and Asthma: A Meta-analysis of Clinical Trials

The Potential of Maternal Dietary Modification for Prevention of Food Allergy

Probiotics for treating eczema

Contact Info

Product

Resources

About