Prenatal and Postpartum Zidovudine Adherence Among Pregnant Women with HIV

Maternal-Fetal Attachment and Health Behaviors among Women with HIV/AIDS

“…Then, social workers could develop effective interventions aiming to remove barriers and promote facilitators for the sustained health and wellbeing of these mothers and infants. Ickovics et al (2002) found a decline in medication adherence from pregnancy to the postpartum period, from low to very low; however, in contrast to findings in this and previously discussed studies, they reported low adherence during pregnancy. The 31% of women in this sample who show detectable amounts of viral load and low CD4 counts could be interpreted in this study as having poor adherence and/or poor response to the prescribed ART regimens.…”

“…Antiretroviral adherence. HIV-infected pregnant women have reported higher rates of adherence across different types of ART regimens during pregnancy compared to the postpartum period (Bardeguez et al, 2008;D'Auria et al, 2006;Ickovics et al, 2002;Kreitchman et al, 2012;Nachega et al, 2012). None of these national and international surveys of pregnant women with HIV/AIDS measured the relationship between maternalfetal attachment and ART adherence.…”

“…Nonetheless, research reveals inconsistent and problematic health behaviors in pregnant women with HIV, especially during the postnatal period when the family, medical and community attention extant in the prenatal period has ceased or diminished (Bardeguez et al, 2008;Ickovics et al, 2002;Wood et al, 2004). An unsteady transition to the postnatal stage places the HIV-infected mother at risk for postpartum depression, HIV-related posttraumatic stress, domestic violence or relapse in substance abuse, all of which disrupt the parental caregiving role and mother-infant relationship.…”

Adherence to Zidovudine for the Prevention of Perinatal Transmission in HIV-Infected Pregnant Women: The Impact of Social Network Factors, Side Effects, and Perceived Treatment Efficacy

“…A majority of women (80%) participatingin the Perinatal Guidelines Evaluation Project (PGEP)-a large, multisite study funded by the CDC in 5 states-reported missing no ZDV doses in the 4 days prior to interview (Wilson et al, 2001); missing ZDV doses was associated with self-reported prenatal drug use (heroin, cocaine) and missing prenatal vitamins. A subset of PGEP women (n = 53) were also assessed with electronic monitors, the Medication Event Monitoring System (MEMS) (Ickovics et al, 2004). In contrast to self-report, the mean rate of adherence (% of prescribed doses taken) for the three weeks prior to delivery was only 50%.…”

Electronic monitoring device event modelling on an individual‐subject basis using adaptive Poisson regression

“…It is possible to use simple pairwise comparison between two time points, more extensive repeated measures analysis of variance, or more general mixed e ects models [2][3][4]. A few studies have developed other means of interpreting and analysing EMD data.…”