Prenatal antioxidant-enriched and pro-oxidant-contained food, IL4 and IL13 pathway genes, and cord blood IgE

Abstract

Prenatal oxidative balance might influence cord blood IgE (cIgE) levels. We aimed to explore if certain prenatal dietary sources of antioxidants and pro-oxidants are associated with cIgE elevation and if they interact with IL4 and IL13 pathway genes. A structured questionnaire was completed during the third trimester of pregnancy for 1107 full-term newborns. Surveyed antioxidant-enriched food included fish, shellfish, and fruit, whereas surveyed pro-oxidant-contained food included fried fish sticks and canned fish. Cord blood was collected for measuring cIgE levels and genotyping IL13 rs1800925, rs20541, rs848, IL4 rs2243250, and STAT6 rs324011. Fairly lean fish consumption showed protection against cIgE elevation (odds ratio [OR] 0.66; 95% CI 0.49–0.90) in the whole sample, while daily fruit (OR 0.46; 95% CI 0.27–0.79) and ≥ monthly canned fish (OR 2.81; 95% CI 1.24–6.36) exhibited associations only in genetically susceptible babies. A prenatal food protective index, comprising any fairly lean fish, daily fruit, and the absence of any canned fish, exerted dose–response protection against cIgE elevation in babies carrying the IL13 rs20541 GA or AA genotype (P for trend < 0.0001; P for interaction = 0.004). We concluded that prenatal antioxidant-enriched and pro-oxidant-contained food consumption may influence cIgE, especially in genetically susceptible babies.

Mollusc and crustacean consumption in the first 1000 days: a scoping review

“…Generally, the researchers found no associations with the outcomes of interest. They did, however, find a gene-specific relationship for interleukin 13 (IL13); for the IL13 gene variant rs20541, statistically significant relationships were found for infants with the GG genotype (40) .…”

“…A study from the United States also found non-significant relationships between average shellfish intake during the first and second trimester and allergy biomarkers in early childhood (39) . One study from China explored the relationship between prenatal shellfish intake and cord blood IgE levels as well as genes implicated in the pathways for interleukins 4 and 13 (40) . Generally, the researchers found no associations with the outcomes of interest.…”