Prenatal arsenic exposure, child marriage, and pregnancy weight gain: Associations with preterm birth in Bangladesh

Rahman, Mohammad L.; Kile, Molly L.; Rodrigues, Ema G.; Valeri, Linda; Raj, Anita; Mazumdar, Maitreyi; Mostofa, Golam; Quamruzzaman, Quazi; Rahman, Mahmudur; Hauser, Russ; Baccarelli, Andrea A.; Liang, Liming; Christiani, David C.

doi:10.1016/j.envint.2017.12.004

Cited by 42 publications

(34 citation statements)

References 81 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In this study, we observed that the effect of miR-1290 on birthweight was stronger when the arsenic concentration was higher in cord blood. In utero arsenic exposure has been associated with increased risk of preterm birth [57] and lower birthweight [27] in this population. Therefore, higher expression of miR-1290 in the placenta could potentially influence birthweight via shortened gestational age and increased arsenic toxicity.…”

Section: Discussionmentioning

confidence: 94%

“…During 2008-2011, we enrolled 1,613 pregnant women aged ≥ 18 years with an ultrasound-confirmed singleton pregnancy of ≤ 16 weeks of gestation and followed them throughout pregnancy. Details of this study, including recruitment and enrollment criteria were previously reported [25,27]. At the end of follow-up, 1,184 singleton live births were recorded after exclusions due to loss of contact before delivery (n = 99), participation withdrawal (n = 121), miscarriage (n = 132), stillbirth (n = 72), and multiple pregnancies (n = 5).…”

Section: Study Population and Subject Selectionmentioning

confidence: 99%

“…Furthermore, the expression of miRNAs is sensitive to environmental exposures, including inorganic arsenic [24], which is an independent risk factor for preterm birth [25] and lower birthweight [26,27]. Therefore, it is possible that the effect of placenta-derived miRNAs on birthweight can be modified by in utero arsenic exposure.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Regulation of birthweight by placenta-derived miRNAs: evidence from an arsenic-exposed birth cohort in Bangladesh

et al. 2018

Self Cite

View full text Add to dashboard Cite

Altered expression of microRNAs (miRNAs) is implicated in fetal growth. However, the mechanisms by which placenta-derived miRNAs regulate birthweight are not well understood. In Phase 1, we compared the expression of 754 miRNAs in the placenta of mothers from two extreme birthweight groups (0.8-2.2 kg vs. 3.3-3.9 kg, n = 77 each) selected from an arsenic-exposed Bangladeshi birth cohort (n = 1,141). We identified 49 miRNAs associated with the extreme birthweight groups and/or gestational age in Phase 1, which were further analyzed in Phase 2 among 364 randomly selected mother-infant pairs. Gestational age was determined by ultrasound. Causal mediation analysis was used to estimate the effect of miRNAs on birthweight considering gestational age a mediator, adjusting for core blood arsenic and other risk factors. miR-1290, miR-195, and let-7g showed significant inverse associations with gestational age, while miR-328 showed significant positive association [false discovery rate (FDR) <0.05]. Via changing gestational age, miR-1290, miR-195, and miR-27a showed significant inverse associations with birthweight, while miR-328 and miR-324-5p showed significant positive associations (FDR <0.05). The effect of miRNAs on birthweight varied by gestational age (for miR-1290, miR-195, miR-328) and in utero arsenic exposure (for miR-1290): stronger effect was observed among infants delivered early in gestation or exposed to higher concentrations of arsenic in cord blood. Gene enrichment analysis with in silico predicted targets identified cell proliferation, inflammation, apoptosis, insulin, and IGF family signaling cascades associated with these miRNAs. Future studies are warranted to replicate these findings and assess these miRNAs as early biomarkers of fetal growth.

show abstract

Section: Discussionmentioning

confidence: 94%

Section: Study Population and Subject Selectionmentioning

confidence: 99%

See 1 more Smart Citation

Regulation of birthweight by placenta-derived miRNAs: evidence from an arsenic-exposed birth cohort in Bangladesh

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

“…Early marriage is also responsible for other maternal risk factors associated with negative birth outcomes (Ikamari, 2005). Studies on how early marriage affects reproductive health revealed that early exposure to sexual life leads women more likely to have different sexually transmitted diseases, pre-term deliveries, pregnancy complications, complications during child birth and so on (Rahman et al, 2018;Kamal and Hassan, 2015). Moreover, poor adoption of family planning, low utilization of contraceptives, poor caring practice of child are also seen to be connected with early marriage.…”

Section: Discussionmentioning

confidence: 99%

“…Lower fertility control can lead to adverse fertility outcomes such as termination of pregnancy and unplanned pregnancy (Godha et al, 2013). In another study carried out in Bangladesh to identify the association between child marriage and preterm birth considering pregnancy weight gain as mediator showed a small but statistically significant indirect effect on preterm birth (RR indirect effect = 1.02; 95% CI: 1.00,1.05) (Rahman et al, 2018). A study which was based in BDHS 2011, showed that still birth, miscarriage and pregnancy termination are significantly associated with child marriage and it was also found that 70.4 % and 23.4% women who got early marriage had still birth and pregnancy termination which were greater than that women who married after getting adult (Kamal and Hassan, 2015).…”

Section: Children Bearing and Delivering Children; A Major Consequencmentioning

confidence: 99%

Causes of Early Marriage and Its Effect on Reproductive Health of Young Mothers in Bangladesh

Kabir¹,

Ghosh²,

Shawly³

2019

American Journal of Applied Sciences

View full text Add to dashboard Cite

The ubiquitous nature of early marriage which practiced across all background and social divides in Bangladesh causing a lot of concerns as according to UNICEF report on "The state of world's children 2017" Bangladesh has the fourth highest prevalence rate of child marriage in the world (59% marriage of women is happened before the age of 18 years). Poverty and low literacy are deciding factors; however, this phenomenon has severe health consequences which most of the times are overlooked and takes for granted in a country like Bangladesh. The study aims on the present situation of early marriage in Bangladesh, its social context and also identifies its effect on reproductive health. The tradition driven by poverty, unwillingness of parents to invest in girl's education, superstition, lack of social security and awareness directly affects girls' education, physical health, psychological well-being and consequently the health of their offspring. Though prohibition of child marriage is legal, but incidents of child marriage are still pervasive, especially in remote areas of Bangladesh due to proper enactment and social insecurity. A study conducted in rural Noakhali, Bangladesh revealed that more than 80% of marriage happened for women under 18 years of age. A study which found that still birth, miscarriage and pregnancy termination are significantly associated with child marriage. Early marriage often followed by adolescent pregnancies has enormous harmful effect on women's health as they are not ready physically and psychologically, hence increases the risk for different sexually transmitted diseases, obstetric fistulas, pre-term deliveries, miscarriage accompanied by mental depression, physical abuse, lack of social coherence and isolation and so on. To prevent child marriage, focusing on the underlying causes of child marriage is imperative and its serious health consequences warrant proper enactment of legislation and addressing the socioeconomic causes that propitiates child marriage.

show abstract

Associations between early marriage and preterm delivery: Evidence from lowland Nepal

Miller

Marphatia

Wells

et al. 2021

American J Hum Biol

View full text Add to dashboard Cite

Objectives: Preterm delivery (<37 weeks gestation) is the largest cause of child mortality worldwide. Marriage and pregnancy during adolescence have been associated with an increased risk of preterm delivery. We investigate independent associations of age at marriage and age at first pregnancy with preterm delivery in a cohort of women from rural lowland Nepal. Methods:We analyzed data from 17 974 women in the Low Birth Weight South Asia Trial. Logistic regression models tested associations of age at marriage and age at first pregnancy with preterm delivery, for primigravida (n = 6 243) and multigravida (n = 11 731) women. Models were adjusted for maternal education, maternal caste, and household asset score.Results: Ninety percent of participants had married at <18 years and 58% had their first pregnancy at <18 years. 20% of participants delivered preterm.Primigravida participants married at ≤14 years had higher odds of preterm delivery than those married ≥18 years, when adjusting for study design (adjusted odds ratio (aOR) 1.45, 95% CI: 1.15-1.83), confounders (aOR 1.28:1.01-1.62) and confounders + age at pregnancy (aOR 1.29: 1.00-1.68). Associations were insignificant for multigravida women. No significant associations were observed between age at first pregnancy and preterm delivery. Discussion: In this population, early marriage, rather than pregnancy, is a risk factor for preterm delivery. We hypothesize that psychological stress, a driver of preterm delivery which is increased among those marrying young, rather than physiological immaturity, drives this association. Further research into the psychological consequences of child marriage in Nepal is needed.

show abstract

Prenatal arsenic exposure, child marriage, and pregnancy weight gain: Associations with preterm birth in Bangladesh

Abstract: Reducing arsenic exposure and ending child marriage could reduce the risk of preterm birth in Bangladesh. Furthermore, enhancing nutritional support to ensure adequate weight gain during pregnancy may provide additional benefits especially for women with a history of child marriage.

Cited by 42 publications

References 81 publications

Regulation of birthweight by placenta-derived miRNAs: evidence from an arsenic-exposed birth cohort in Bangladesh

Regulation of birthweight by placenta-derived miRNAs: evidence from an arsenic-exposed birth cohort in Bangladesh

Causes of Early Marriage and Its Effect on Reproductive Health of Young Mothers in Bangladesh

Associations between early marriage and preterm delivery: Evidence from lowland Nepal

Contact Info

Product

Resources

About