Prenatal Caffeine Exposure and Child IQ at Age 5.5 Years: The EDEN Mother-Child Cohort

Galèra, Cédric; Bernard, Jonathan Y.; Waerden, Judith van der; Bouvard, M.; Lioret, Sandrine; Forhan, Anne; Agostini, Maria De; Melchior, Maria; Heude, Barbara

doi:10.1016/j.biopsych.2015.08.034

Cited by 42 publications

(38 citation statements)

References 27 publications

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“…Generalizing the results of animal studies to humans is always speculative, but these results strongly justify conducting prospective studies in humans. Interestingly, in keeping with animal data, greater exposure to caffeine during pregnancy is associated with a lower IQ in children at age 5.5 years (139). This finding again supports the need for additional studies in humans.…”

Section: Caffeine Toxicitysupporting

confidence: 64%

“…This study found no meaningful relationship between maternal caffeine intake during pregnancy and a range of behavioral and cognitive measures in children 4–7 years old. However, another study of 1,083 mother–child pairs revealed that children who were born to mothers who estimated caffeine intake >200 mg/day during pregnancy had an odds ratio of 2.3 (95% confidence interval of 1.13–4.69) of having a child with a lower IQ at age of 5.5 years compared to the reference population of mothers reporting <100 mg/day of caffeine consumption (139). A study by Li et al (154) reported that maternal caffeine intake was associated with increased odds of childhood obesity, with each 100-mg increase in daily maternal caffeine intake being associated with a 23% higher odds of obesity at age 15 years (127), although a study by Klebanoff and Keim found no relationships between maternal caffeine consumption and childhood obesity (152, 153).…”

Section: Caffeine Toxicitymentioning

confidence: 99%

“…These studies also measured different outcomes in the offspring. Klebanoff and Keim (152, 153) had the most comprehensive battery of cognitive and behavioral outcomes, but Galera et al (139) only measured IQ (The Wechsler Preschool and Primary Scale of Intelligence Third Edition), and Li et al (127) only measured weight and weight gain in the offspring (139, 152–154). Meaningful comparisons of studies are difficult when the methods for assessing caffeine intake and the outcomes are different.…”

Section: Caffeine Toxicitymentioning

confidence: 99%

See 2 more Smart Citations

The Safety of Ingested Caffeine: A Comprehensive Review

Temple¹,

Bernard²,

Lipshultz³

et al. 2017

Front. Psychiatry

381

254

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Caffeine is the most widely consumed psychoactive drug in the world. Natural sources of caffeine include coffee, tea, and chocolate. Synthetic caffeine is also added to products to promote arousal, alertness, energy, and elevated mood. Over the past decade, the introduction of new caffeine-containing food products, as well as changes in consumption patterns of the more traditional sources of caffeine, has increased scrutiny by health authorities and regulatory bodies about the overall consumption of caffeine and its potential cumulative effects on behavior and physiology. Of particular concern is the rate of caffeine intake among populations potentially vulnerable to the negative effects of caffeine consumption: pregnant and lactating women, children and adolescents, young adults, and people with underlying heart or other health conditions, such as mental illness. Here, we review the research into the safety and safe doses of ingested caffeine in healthy and in vulnerable populations. We report that, for healthy adults, caffeine consumption is relatively safe, but that for some vulnerable populations, caffeine consumption could be harmful, including impairments in cardiovascular function, sleep, and substance use. We also identified several gaps in the literature on which we based recommendations for the future of caffeine research.

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Section: Caffeine Toxicitysupporting

confidence: 64%

Section: Caffeine Toxicitymentioning

confidence: 99%

Section: Caffeine Toxicitymentioning

confidence: 99%

See 1 more Smart Citation

The Safety of Ingested Caffeine: A Comprehensive Review

Temple¹,

Bernard²,

Lipshultz³

et al. 2017

Front. Psychiatry

381

254

View full text Add to dashboard Cite

show abstract

“…In the study, detailed questionnaire and clinical data on phenotypes and exposures and biological samples were collected from pregnancy until the child was 8 years old. Relevant findings from the ALPHABET project include tracking of dietary patterns from infancy to preschool age (Lioret et al 2015), associations between maternal dietary factors (caffeine and fatty acids) with offspring IQ (Galera et al 2016), neurodevelopment (Bernard et al 2013) and DNA methylation (Azzi et al 2014), and between gestational weight change and offspring adiposity (Diouf et al 2014;Jacota et al 2017).…”

Section: The Eden Mother-child Cohort Studymentioning

confidence: 99%

Early‐life dietary and epigenetic influences on childhood musculoskeletal health: Update on the UK component of the ALPHABET project

Curtis

Suderman²,

Phillips

et al. 2018

Nutrition Bulletin

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The ALPHABET project, funded through the European Research Area Healthy Diet for a Healthy Life Biomarkers call, aims to expand the knowledge base regarding interactions between diet, epigenetics and offspring health, characterising biomarkers that may inform future health strategies. This review focuses on the UK Biotechnology and Biological Sciences Research Council (BBSRC)‐funded component in which the aim was to (1) generate and collate early‐life epigenetic data and (2) investigate early diet and epigenetic marks as predictors of later bone health. The project builds on a wealth of evidence implicating environmental factors, such as maternal diet and body composition, as influences on the long‐term health and development of the offspring, and that these relationships might be mediated at least in part through epigenetic signals. Experimental studies in animal models have demonstrated that manipulation of maternal diet during pregnancy leads to altered offspring epigenetic marking and phenotype. Human studies convincingly demonstrate associations between early environment and later health and disease for outcomes across musculoskeletal, respiratory, neurodevelopmental and cardiometabolic health. The priority now is to find ways in which such observations can be translated into improved lifelong health. A key approach is to identify early biomarkers of adverse health outcomes and then to test these, and subsequent interventions, in trials aimed at identifying strategies to optimise health throughout the life course. The ALPHABET project will inform this process for musculoskeletal outcomes, and the project as a whole should help elucidate not only novel mechanisms, but also potential strategies to reduce the burden of musculoskeletal, respiratory, neurodevelopmental and cardiometabolic disease in future generations.

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“…In mice, caffeine exposure during pregnancy and until weaning delays 63 the migration and integration of GABA neurons, enhances seizure susceptibility, as well as 64 alters brain rhythms and hippocampus-dependent memory function in the offspring (Silva et 65 al., 2013;Fazeli et al, 2017). Although it is difficult to generalize rodent studies to humans, a 66 study in mother-child pairs showed an association between caffeine exposure during pregnancy 67 and impaired cognitive development (Galéra et al, 2015). Guidelines for pregnant women 68 recommend to limit the amount of caffeine consumption to 200-300 mg/kg (Gynecologists, 69 2010).…”

Section: Introduction 35mentioning

confidence: 99%

Caffeine consumption during pregnancy accelerates the development of cognitive deficits in offspring in a model of tauopathy

Bernard

Zappettini

Faivre

et al. 2019

Preprint

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20Psychoactive drugs used during pregnancy can affect the development of the brain of offspring, 21 directly triggering neurological disorders or increasing the risk for their occurrence. Caffeine is 22 the most widely consumed psychoactive drug, including during pregnancy. In Wild type mice, 23 early life exposure to caffeine renders offspring more susceptible to seizures. Here, we tested 24 the long-term consequences of early life exposure to caffeine in THY-Tau22 transgenic mice, 25 a model of Alzheimer's disease-like Tau pathology. Caffeine exposed mutant offspring 26 developed cognitive earlier than water treated mutants. Electrophysiological recordings of 27 hippocampal CA1 pyramidal cells in vitro revealed that early life exposure to caffeine changed 28 the way the glutamatergic and GABAergic drives were modified by the Tau pathology. We 29 conclude that early-life exposure to caffeine affects the Tau phenotype and we suggest that 30 caffeine exposure during pregnancy may constitute a risk-factor for early onset of Alzheimer's 31 disease-like pathology. 32 33 34 6 gluconate, 10.0 mM HEPES, 15.0 mM sodium gluconate, 0.2 mM EGTA, 4.0 mM NaCl, pH 126 7.2. After 20 minutes recovery in a preincubation solution (110 mM Choline chloride, 2.5 mM 127KCl, 1.25 mM NaH2PO4, 10 mM MgCl2, 0.5 mM CaCl2, 25 mM NaHCO3, 10 mM D-glucose, 128 5 mM sodium pyruvate equilibrated with 5% CO2 in 95% O2 at room temperature), slices were 129 perfused for at least one hour with aCSF containing 126.0 mM NaCl, 25.0 mM NaHCO3, 10.0 130 mM D-glucose, 3.5 mM KCl, 2.0 mM CaCl2, 1.3 mM MgCl2.6H2O and 1.2 mM NaH2PO4 131 equilibrated with 5% CO2 in 95% O2 at room temperature and transferred to a chamber 132 containing the same aCSF, kept at a temperature between 33 ºC and 35 ºC. Cells were recorded 133 under visual control (Nikon FN1 microscope -Scientifica Patch Star manipulators) with an 134

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Prenatal Caffeine Exposure and Child IQ at Age 5.5 Years: The EDEN Mother-Child Cohort

Cited by 42 publications

References 27 publications

The Safety of Ingested Caffeine: A Comprehensive Review

The Safety of Ingested Caffeine: A Comprehensive Review

Early‐life dietary and epigenetic influences on childhood musculoskeletal health: Update on the UK component of the ALPHABET project

Caffeine consumption during pregnancy accelerates the development of cognitive deficits in offspring in a model of tauopathy

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