Prenatal cocaine decreases the trophic factor S-100β and induced microcephaly: Reversal by postnatal 5-HT1A receptor agonist

Akbari, Homayoon M.; Whitaker‐Azmitia, Patricia M.; Azmitia, Efrain C.

doi:10.1016/0304-3940(94)90259-3

Cited by 79 publications

(32 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The areas for analysis were photographed from coded slides to include layers II– V of the temporal and fusiform cortices, midbrain tegmentum, pontine fibers and cerebellar cortex. All pictures were stored by code for analysis using NIH ImageJ as previously described (see Akbari et al 1994; Azmitia et al 2011a, b). Stereological measures were made directly from the brain slides as previously described (Boldrini et al 2012).…”

Section: Methodsmentioning

confidence: 99%

Persistent Angiogenesis in the Autism Brain: An Immunocytochemical Study of Postmortem Cortex, Brainstem and Cerebellum

Azmitia

Saccomano

Alzoobaee

et al. 2015

J Autism Dev Disord

View full text Add to dashboard Cite

In the current work, we conducted an immunocytochemical search for markers of ongoing neurogenesis (e.g. nestin) in auditory cortex from postmortem sections of autism spectrum disorder (ASD) and age-matched control donors. We found nestin labeling in cells of the vascular system, indicating blood vessels plasticity. Evidence of angiogenesis was seen throughout superior temporal cortex (primary auditory cortex), fusiform cortex (face recognition center), pons/midbrain and cerebellum in postmortem brains from ASD patients but not control brains. We found significant increases in both nestin and CD34, which are markers of angiogenesis localized to pericyte cells and endothelial cells, respectively. This labeling profile is indicative of splitting (intussusceptive), rather than sprouting, angiogenesis indicating the blood vessels are in constant flux rather than continually expanding.

show abstract

Section: Methodsmentioning

confidence: 99%

Persistent Angiogenesis in the Autism Brain: An Immunocytochemical Study of Postmortem Cortex, Brainstem and Cerebellum

Azmitia

Saccomano

Alzoobaee

et al. 2015

J Autism Dev Disord

View full text Add to dashboard Cite

show abstract

“…However, higher (micromolar) levels of S100B can be cytotoxic (Fano et al 1993). In rodent models, decreased levels of S100B are found following several prenatal manipulations including stress (Van den Hove et al 2006) and cocaine (Akbari et al 1994) exposure. Such prenatal exposures, and concomitant S100B deficits, are associated with altered central serotonin levels, supporting the theory that increased extracellular serotonin levels (e.g., following SSRI exposure) in the developing brain may hinder the growth of 5-HT neurons via autoregulation.…”

Section: Serotonin Manipulation Effects On Brain and Behavior: Preclimentioning

confidence: 99%

Central nervous system effects of prenatal selective serotonin reuptake inhibitors: sensing the signal through the noise

2013

View full text Add to dashboard Cite

Rationale Women are increasingly prescribed selective serotonin reuptake inhibitors (SSRIs) during pregnancy, with potential implications for neurodevelopment. Whether prenatal SSRI exposure has an effect on neurodevelopment and behavior in the offspring is an important area of investigation. Objectives The aim of this paper was to review the existing preclinical and clinical literature of prenatal SSRI exposure on serotonin-related behaviors and markers in the offspring. The goal is to determine if there is a signal in the literature that could guide clinical care and/or inform research. Results Preclinical studies (n = 4) showed SSRI exposure during development enhanced depression-like behavior. Half of rodent studies examining anxiety-like behavior (n = 13) noted adverse effects with SSRI exposure. A majority of studies of social behavior (n = 4) noted a decrease in sociability in SSRI exposed offspring. Human studies (n = 4) examining anxiety in the offspring showed no adverse effects of prenatal SSRI exposure. The outcome of one study suggested that children with autism were more likely to have a mother who was prescribed an SSRI during pregnancy. Conclusions Preclinical findings in rodents exposed to SSRIs during development point to an increase in depression- and anxiety-like behavior and alteration in social behaviors in the offspring, though both the methods used and the findings were not uniform. These data are not robust enough to discourage use of SSRIs during human pregnancy, particularly given the known adverse effects of maternal mental illness on pregnancy outcomes and infant neurodevelopment. Future research should focus on consistent animal models and prospective human studies with larger samples.

show abstract

“…These effects are particularly profound in the fetus in which elevated sympathetic tone has been demonstrated 28–31. Cocaine affects neuronal formation, proliferation and early connectivity,32–34 and disrupts neuronal migration and resulting cortical architecture 35–38. Cocaine also affects the expression of transcription factors (IEGs or immediate early genes) along dopaminergic39,40 and serotonergic pathways 41.…”

Section: Cocainementioning

confidence: 99%

Fetal Effects of Psychoactive Drugs

Salisbury¹,

Ponder²,

Padbury³

et al. 2009

Clinics in Perinatology

View full text Add to dashboard Cite

There has been a longstanding concern with the fetal effects of psychoactive drug use by pregnant women. In this article we describe the effects of three drugs with similar molecular targets that involve monoaminergic transmitter systems. These stimulants include the illegal drugs cocaine and methamphetamine and the class of selective serotonin re-uptake inhibitors (SSRIs) used to treat maternal depression during pregnancy. We discuss the mechanisms of action of each drug, including a possible common epigenetic mechanism for their effects on the developing child. We also discuss fetal neurobehavioral techniques that may be useful in the early detection of the effects of in utero drug exposure.In the past three decades, the concept of behavioral teratology 1 expanded the field of teratology to examine behavioral effects in the neonate due to acute exposure to substances in utero, including environmental, nutritional, and drug exposures. 2,3 The developmental consequences of prenatal exposure to a toxic substance may include central nervous system (CNS) insult related to the period during gestation of the exposure. In contrast to the effects of drugs on the adult brain, which result in deformation of the developed brain, fetal effects are more likely to produce malformation in which the developing brain is prevented from forming normally. 4 The effects of exposure during the first half of gestation will impact processes related to cytogenesis and histogenesis whereas effects during the second half of gestation relate to brain growth and differentiation. During this organizational phase in the second half of gestation, progressive events (neuroblast proliferation and migration, axonal projection, and Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Recent years have seen further expansion of the principles of behavioral teratology to examine exposure effects on the human fetus at the time of the exposure. Epigenetic and organismic models of developmental theory suggest that true understanding of a developing system can occur with the study of its organization of form and structure as it moves toward a teleological state. 5,6 This study includes examination of the mutual influences of genes, physiology, and behavior as well as the physical, cultural, and social environments of the organism. 6 NIH Public AccessIncreasing evidence from preclinical, prospective clinical and epidemiological studies suggests that many biological factors acting during prenatal life are associated with adult disease as well as long term neurobehavioral abnormalities 7-17 and behavioral disorders. [18...

show abstract

Prenatal cocaine decreases the trophic factor S-100β and induced microcephaly: Reversal by postnatal 5-HT1A receptor agonist

Cited by 79 publications

References 12 publications

Persistent Angiogenesis in the Autism Brain: An Immunocytochemical Study of Postmortem Cortex, Brainstem and Cerebellum

Persistent Angiogenesis in the Autism Brain: An Immunocytochemical Study of Postmortem Cortex, Brainstem and Cerebellum

Central nervous system effects of prenatal selective serotonin reuptake inhibitors: sensing the signal through the noise

Fetal Effects of Psychoactive Drugs

Contact Info

Product

Resources

About