Prenatal Cocaine Exposure: Drug and Environmental Effects at 9 Years

Singer, Lynn T.; Nelson, Suchitra; Short, Elizabeth J.; Min, Meeyoung O.; Lewis, Barbara; Russ, Sandra W.; Minnes, Sonia

doi:10.1016/j.jpeds.2008.01.001

Cited by 98 publications

(131 citation statements)

References 26 publications

Supporting

Mentioning

123

Contrasting

Order By: Relevance

“…We found a significant association between PCE and short-term memory (Richardson et al, 2009), and other researchers have reported deficits in specific areas such as verbal reasoning/memory (Bennett et al, 2002), executive function , cognitive processing/learning (Bridgett et al, 2011;Mayes et al, 2005Mayes et al, , 2007, visual spatial/math skills (Singer et al, , 2008, visual motor integration Schroder et al, 2004), and attention, inhibitory control, and impulsivity (Accornero et al, 2007;Bandstra et al, 2001;Bendersky et al, 2003;Carmody et al, 2011;Noland et al, 2005;Rose-Jacobs et al, 2009). However, there are also reports that show no negative effects of PCE on specific areas of cognition (Betancourt et al, 2011;Eyler et al, 2009;Hurt et al, 2009;Li et al, 2009;, and most groups, including ours, do not find a relation between PCE and global cognitive development (Accornero et al, 2007;Bandstra et al, 2002;Frank et al, 2005;Hurt et al, 1997Hurt et al, , 2001Messinger et al, 2004;Morrow et al, 2004Morrow et al, , 2006Singer et al, 2004).…”

Section: Introductionsupporting

confidence: 74%

Effects of prenatal cocaine exposure on adolescent development

Richardson

Goldschmidt

Day

2009

Neurotoxicology and Teratology

View full text Add to dashboard Cite

The associations between prenatal cocaine exposure (PCE) and adolescent behavior, cognitive development, and physical growth were examined in 219 15-year-olds who have participated in a longitudinal study since their fourth gestational month. During the first trimester, 42% of the women used cocaine, with use declining across pregnancy. At the 15-year follow-up, the caregivers were, on average, 43 years old, had 13 years of education, and 50% were African American. First trimester PCE was not associated with global cognitive development or with measures of learning and memory. First trimester PCE was significantly related to adolescentreported delinquent behavior, poorer problem solving and abstract reasoning, and reduced weight, height, and head circumference at 15 years. These results were significant after other factors that affect these domains were controlled in regression analyses. In addition, exposure to violence partially mediated the effect of PCE on delinquent behavior. These adolescent domains are important because they are predictors of poorer adult functioning.

show abstract

Section: Introductionsupporting

confidence: 74%

Effects of prenatal cocaine exposure on adolescent development

Richardson

Goldschmidt

Day

2009

Neurotoxicology and Teratology

View full text Add to dashboard Cite

show abstract

“…Morrow et al (2006) reported IUCE was not associated with the Wechsler Individual Achievement Test-Second Edition (WIAT-II) or IQ at age 7; however, children with IUCE were 2.8 times more likely to have a learning disability. In contrast, Singer et al (2008) reported that at 9 years, achievement scores were associated with prenatal alcohol and marijuana, postnatal lead exposures, and home environment. IUCE was linked to perceptual reasoning.…”

Section: Introductionmentioning

confidence: 91%

Intrauterine substance exposures and Wechsler Individual Achievement Test-II scores at 11 years of age

Rose-Jacobs

Augustyn

Martin

et al. 2012

Vulnerable Children and Youth Studies

View full text Add to dashboard Cite

The goal of this study was to evaluate whether intrauterine exposure to cocaine, alcohol, tobacco, or marijuana was associated with unique variance in children's academic achievement test scores after controlling for other substance exposures and contextual variables. Academic achievement scores (Wechsler Individual Achievement Test-Second Edition (WIAT-II)) were collected from 119, low-income, urban 11-year-olds enrolled in a prospective longitudinal study of intrauterine cocaine exposure (IUCE). Newborn recruitment eligibility included >36 weeks gestational age, no neonatal intensive care, no intrauterine exposure to illicit drugs except cocaine or marijuana, and no evidence of fetal alcohol syndrome (FAS). Intrauterine substance exposures (cocaine, marijuana, alcohol, tobacco) were documented in the newborn period using biological assays and maternal self-report. Multivariate analyses evaluated the relationship of each intrauterine exposure and each WIAT-II score controlling for contextual variables and the other substance exposures. In secondary analyses, the Child Depression Inventory (CDI) was added to final models. Results indicate that neither IUCE nor intrauterine exposure to marijuana or tobacco was associated with lower WIAT-II scores in multivariable analyses. Intrauterine alcohol exposure predicted significant variance in Math Reasoning and Spelling scores, but inclusion of children's depressive symptoms attenuated the relationship. Lower maternal education and maternal US birth were also associated with lower WIAT-II scores. Our analyses indicate that among low-income, urban 11-year-olds without a diagnosis of FAS, intrauterine alcohol exposure was negatively associated with math and spelling achievement scores after controlling for other intrauterine substance exposures and contextual factors. That relationship in this sample was partially mediated by children's depressive symptoms, but we cannot establish whether these lower achievement scores precede or follow depressive symptoms. Our findings highlight that neurobehavioral studies evaluating a primary potential neuroteratogen should evaluate other associated intrauterine exposures and contextual factors.

show abstract

“…Resolving the consequences of prenatal THC on human fetal brain development is complicated by variable THC exposures (dose, timing, and duration) between pregnancies, confounding exposures to multiple illicit drugs [29], and genotype-dependent effects [30]. Because neural cells differentiated from human-induced pluripotent stem cells (hiPSCs) most resemble fetal brain tissue [31,32,33,34], they provide an unprecedented platform for studying the molecular, cellular, and functional results of fetal THC exposure to neural cells, across a variety of genetic backgrounds.…”

Section: Introductionmentioning

confidence: 99%

THC Treatment Alters Glutamate Receptor Gene Expression in Human Stem Cell-Derived Neurons

et al. 2017

View full text Add to dashboard Cite

Given the cognitive and behavioral effects following in utero Δ9-tetrahydrocannabinol (THC) exposure that have been reported in humans and rodents, it is critical to understand the precise consequences of THC on developing human neurons. Here, we utilize excitatory neurons derived from human-induced pluripotent stem cells (hiPSCs), and report that in vitro THC exposure reduced expression of glutamate receptor subunit genes (GRIA1, GRIA2, GRIN2A, and GRIN2B). By expanding these studies across hiPSC-derived neurons from individuals with a variety of genotypes, we believe that a hiPSC-based model will facilitate studies of the interaction of THC exposure and the genetic risk factors underlying neuropsychiatric disease vulnerability.

show abstract

Prenatal Cocaine Exposure: Drug and Environmental Effects at 9 Years

Cited by 98 publications

References 26 publications

Effects of prenatal cocaine exposure on adolescent development

Effects of prenatal cocaine exposure on adolescent development

Intrauterine substance exposures and Wechsler Individual Achievement Test-II scores at 11 years of age

THC Treatment Alters Glutamate Receptor Gene Expression in Human Stem Cell-Derived Neurons

Contact Info

Product

Resources

About