Prenatal complications and neurodevelopmental outcomes in offspring: interactions and confounders

Schoretsanitis, Georgios; Deligiannidis, Kristina M.

doi:10.1111/acps.13236

Cited by 4 publications

(3 citation statements)

References 17 publications

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“…Moreover, this type of studies is vulnerable to bias because of unmeasured confounding and lower internal validity compared with randomised controlled trials. 83,84 In fact, it is unclear if some of the investigated factors were proxies for other factors or shared background risk. It should be noted, however, that this risk of bias is taken into consideration by GRADE, which suggests rating the certainty of estimates from observational studies as low quality instead of high quality, to acknowledge issues with internal validity.…”

Section: ≥1000mentioning

confidence: 99%

Risk factors of postpartum depression and depressive symptoms: umbrella review of current evidence from systematic reviews and meta-analyses of observational studies

et al. 2022

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Background Evidence on risk factors for postpartum depression (PPD) are fragmented and inconsistent. Aims To assess the strength and credibility of evidence on risk factors of PPD, ranking them based on the umbrella review methodology. Method Databases were searched until 1 December 2020, for systematic reviews and meta-analyses of observational studies. Two reviewers assessed quality, credibility of associations according to umbrella review criteria (URC) and evidence certainty according to Grading of Recommendations-Assessment-Development-Evaluations criteria. Results Including 185 observational studies (n = 3 272 093) from 11 systematic reviews, the association between premenstrual syndrome and PPD was the strongest (highly suggestive: odds ratio 2.20, 95%CI 1.81–2.68), followed by violent experiences (highly suggestive: odds ratio (OR) = 2.07, 95%CI 1.70–2.50) and unintended pregnancy (highly suggestive: OR=1.53, 95%CI 1.35–1.75). Following URC, the association was suggestive for Caesarean section (OR = 1.29, 95%CI 1.17–1.43), gestational diabetes (OR = 1.60, 95%CI 1.25–2.06) and 5-HTTPRL polymorphism (OR = 0.70, 95%CI 0.57–0.86); and weak for preterm delivery (OR = 2.12, 95%CI 1.43–3.14), anaemia during pregnancy (OR = 1.47, 95%CI 1.17–1.84), vitamin D deficiency (OR = 3.67, 95%CI 1.72–7.85) and postpartum anaemia (OR = 1.75, 95%CI 1.18–2.60). No significant associations were found for medically assisted conception and intra-labour epidural analgesia. No association was rated as ‘convincing evidence’. According to GRADE, the certainty of the evidence was low for Caesarean section, preterm delivery, 5-HTTLPR polymorphism and anaemia during pregnancy, and ‘very low’ for remaining factors. Conclusions The most robust risk factors of PDD were premenstrual syndrome, violent experiences and unintended pregnancy. These results should be integrated in clinical algorithms to assess the risk of PPD.

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Section: ≥1000mentioning

confidence: 99%

Risk factors of postpartum depression and depressive symptoms: umbrella review of current evidence from systematic reviews and meta-analyses of observational studies

et al. 2022

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“…The results of our prospective cohort study showed that women who conceived after IVF have an increased risk of antenatal anxiety and decreased risk of antenatal depression between the 30th and 32nd gestational week in comparison with women who conceived spontaneously, although both associations were not significant before and after propensity score matching to account for potential confounders [ 7 ]. After propensity score matching, the IVF group had a significantly higher total HAM-A score.…”

Section: Discussionmentioning

confidence: 99%

Is Conception by Means In Vitro Fertilization Associated With Increased Risk of Antenatal Anxiety and Depression?

Arvanitidou¹,

Kalaitzopoulos²,

Samartzis³

et al. 2023

Cureus

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Mental health during pregnancy is a very important public health issue with negative effects on both maternal and child outcomes. The aim of our study is to examine the possible association between conception via in vitro fertilization (IVF) and anxiety or depression during the third pregnancy trimester in the Greek population during the years of financial crisis. Materials and MethodsThis single-center prospective cohort study was conducted in a tertiary university hospital during the period 2017-2018. Pregnant women attending the Antenatal Care Program between 30th-32nd gestational week were asked to complete Hamilton Anxiety Rating Scale (HAM-A) and Beck Depression Inventory (BDI). A propensity score match for 10 variables was conducted in a 1:3 ratio. ResultsOf the 521 eligible patients, 446 women were included in our study. Four hundred fourteen of them conceived spontaneously, and 32 via IVF. After propensity score matching, 76 remained in the analysis, of whom 57 conceived spontaneously and 19 with IVF. The IVF group had a higher rate of anxiety (18.8%) and a lower rate of depression (9.4%) than the spontaneous conception group (13.5% and 13.5%, respectively), but the differences were not statistically significant before and after propensity score matching. ConclusionOur study showed that pregnancies after IVF had a higher incidence of antenatal anxiety and a lower incidence of antenatal depression in comparison to pregnancies that were conceived naturally, although the differences did not reach statistical significance.

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“…However, the literature suffers from considerable inconsistencies depending on the methodological approach, including the type of outcomes used as fetal growth proxy. 8,13,14 Ultrasonography studies in women have suggested increased motor activity, altered rapid-eye eye movement sleep, and decreased fetal heart variability in fetuses with versus without exposure to antidepressants. [15][16][17] A more recent fetal echocardiography study of 40 antidepressant-treated pregnant women reported septal defects in 7 fetuses in different phases of the gestation.…”

mentioning

confidence: 99%

Antenatal Antidepressant Prescription Associated With Reduced Fetal Femur Length but Not Estimated Fetal Weight

Schoretsanitis

Carlini

John

et al. 2021

J Clin Psychopharmacol

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Prenatal complications and neurodevelopmental outcomes in offspring: interactions and confounders

Cited by 4 publications

References 17 publications

Risk factors of postpartum depression and depressive symptoms: umbrella review of current evidence from systematic reviews and meta-analyses of observational studies

Risk factors of postpartum depression and depressive symptoms: umbrella review of current evidence from systematic reviews and meta-analyses of observational studies

Is Conception by Means In Vitro Fertilization Associated With Increased Risk of Antenatal Anxiety and Depression?

Antenatal Antidepressant Prescription Associated With Reduced Fetal Femur Length but Not Estimated Fetal Weight

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