Prenatal course and outcome in 103 cases of fetal spina bifida: a single center experience

Amari, F.; Junkers, Wiebe; Hartge, D.R.; Beyer, Dániel; Axt-Fliedner, R; Weichert, J.

doi:10.3109/00016349.2010.512062

Cited by 14 publications

(11 citation statements)

References 22 publications

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“…In our cohort, 57% of the parents elected to terminate the pregnancy. This rate is similar to that reported in the literature. In a retrospective study including 103 cases in which spina bifida was diagnosed prenatally, 66% of the parents elected for termination.…”

Section: Discussionsupporting

confidence: 88%

“…This rate is similar to that reported in the literature. In a retrospective study including 103 cases in which spina bifida was diagnosed prenatally, 66% of the parents elected for termination. However, in a large study evaluating prenatal diagnosis and rate of termination of pregnancy affected by neural tube defects in different centers across Europe, the corresponding rate of termination in fetuses with isolated spina bifida varied between 17 and 100%.…”

Section: Discussionsupporting

confidence: 85%

See 1 more Smart Citation

Prenatal prediction of need for ventriculoperitoneal shunt in open spina bifida

Khalil

Caric

Papageorghiou

et al. 2014

Ultrasound in Obstet & Gyne

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 85%

Prenatal prediction of need for ventriculoperitoneal shunt in open spina bifida

Khalil

Caric

Papageorghiou

et al. 2014

Ultrasound in Obstet & Gyne

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“…We identified 15 articles meeting inclusion criteria using the search strategy (Harmon et al, 1995;Forrester and Merz, 2000;Waller et al, 2000;Olde Scholtenhuis et al, 2003;Biggio et al, 2004;Garne et al, 2005;Ghi et al, 2006;Nikkila et al, 2006;Tairou et al, 2006;Poretti et al, 2008;Aguilera et al, 2009;Amari et al, 2010;Lu et al, 2011;Machado et al, 2012). One additional article was found using Google Scholar (this article had cited one of the articles identified using the search strategy) (Adama van and one article was known to the authors and included (Shulman et al, 1994).…”

Section: Resultsmentioning

confidence: 99%

Pregnancy termination following prenatal diagnosis of anencephaly or spina bifida: A systematic review of the literature

Johnson¹,

Honein²,

Flanders³

et al. 2012

Birth Defects Research

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Background-In regions where prenatal screening for anencephaly and spina bifida is widespread, many cases of these defects are prenatally diagnosed. The purpose of this study was to estimate the frequency of termination of pregnancy (TOP) following prenatal diagnosis of anencephaly or spina bifida and to investigate factors associated with TOP that might lead to selection bias in epidemiologic studies.

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“…Long‐term follow‐up demonstrated good cognitive outcome in infants born since 2000, with intelligence quotient within the normal range in 81.4% of children with open SB and 77.8% of children with closed SB. In the subgroup of open SB defects, the percentage of subjects needing a wheelchair decreased between time periods; in Group 2, about 68% of infants were able to walk, with or without an orthopedic device (Table ), whereas other studies reported a lower proportion (54–59%). About 38% of subjects with a repaired open SB defect reported normal or only mildly impaired sphincteric function (Table ).…”

Section: Discussionmentioning

confidence: 98%

Prenatal diagnosis, natural history, postnatal treatment and outcome of 222 cases of spina bifida: experience of a tertiary center

Masini

Luca

Noia

et al. 2019

Ultrasound in Obstet & Gyne

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Objectives To report on the prenatal ultrasonographic diagnosis of spina bifida (SB) and its natural history, treatment and long‐term outcome in a large tertiary referral center. Methods All cases of SB diagnosed between February 1980 and December 2015 in the Obstetric Prenatal Diagnosis Day Unit of the Obstetrics and Gynecology Department at the Catholic University of the Sacred Heart, Rome, were reviewed. All infants with an open defect were delivered by elective Cesarean section and underwent early repair of the spinal defect. A ventriculoperitoneal (VP) shunt and/or third ventriculostomy was performed when needed. Complete postnatal follow‐up was carried out by our multidisciplinary team in the majority of cases. The cohort was analyzed in two groups: Group 1 included patients referred between February 1980 and December 1999; Group 2 included patients referred between January 2000 and December 2015. Results There was a total of 222 cases of SB with a prenatal diagnosis rate of 94.6% (n = 210), with the majority of defects being meningomyeloceles (n = 142 (64.0%)), affecting the lumbosacral level (n = 110 (49.5%)) and being ≥ 2 cm in size (n = 163/195 (83.6%)). There were 174 (78.4%) live births, with more terminations in Group 2 (26.1%) than in Group 1 (10.8%; P = 0.003). Postnatal surgical repair was conducted in 157 cases (99.4% of eligible cases), with death of an infant who was operated on occurring more often in Group 1 (14.1%) than in Group 2 (4.2%; P = 0.03). VP shunt placement was required in 60.3% of infants operated on after January 2000. Long‐term follow‐up was available for 136 children (111 with open defects and 25 with closed defects). Infants born since 2000 with an open defect had normal ambulation or a mild defect in 50% of cases and normal or mild deficit of sphincter function in 37.8% of cases. An intelligence quotient of ≥ 70 was observed in the majority of children (81.4%; 35/43 cases). Worse motor function was associated with progressive prenatal ventriculomegaly, level of lesion and VP shunt placement. Conclusions We describe the prenatal diagnosis, natural history and long‐term outcome of a large contemporary cohort of SB fetuses and infants. In an era of pioneering fetal surgical techniques for in‐utero SB repair, it is important to acknowledge that advances in conventional neonatology and pediatric neurosurgery have allowed increased life expectancy and improved quality of life in patients with SB. Copyright © 2018 ISUOG. Published by John Wiley & Sons Ltd.

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Prenatal course and outcome in 103 cases of fetal spina bifida: a single center experience

Abstract: Spina bifida can result in a spectrum of disabilities that frequently lead to an impairment of bladder, bowel and motor function. The motor function depended on level of the lesion.

Cited by 14 publications

References 22 publications

Prenatal prediction of need for ventriculoperitoneal shunt in open spina bifida

Prenatal prediction of need for ventriculoperitoneal shunt in open spina bifida

Pregnancy termination following prenatal diagnosis of anencephaly or spina bifida: A systematic review of the literature

Prenatal diagnosis, natural history, postnatal treatment and outcome of 222 cases of spina bifida: experience of a tertiary center

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