Prenatal development of sympathetic innervation of the human pancreas

Krivova, Yuliya; Proshchina, Alexandra; Otlyga, Dmitry; Леонова, О.Г.; Saveliev, S. V.

doi:10.1016/j.aanat.2021.151880

Cited by 7 publications

(4 citation statements)

References 54 publications

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“…[25] In addition to mesenchyme, progenitors of endothelial and neural lineages infiltrate the pancreas during the secondary transition attracted by signals from pro-endocrine trunk regions and repelled by tip cells. [59][60][61][62][63] Ongoing vascularization regulates pancreas growth and branching by inhibiting tip cell growth in the trunk region. [18,19] In the above examples, the global mesenchymal and endothelial populations in the pancreas were targeted, yet studies targeting more specific mesenchymal subpopulations are needed to uncover the functionality beyond the molecular mesenchymal and endocrine heterogeneity.…”

Section: Pancreatic Niche Controls Plexus-to-duct Remodeling and Bran...mentioning

confidence: 99%

Deep into the niche: Deciphering local endoderm‐microenvironment interactions in development, homeostasis, and disease of pancreas and intestine

et al. 2023

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Unraveling molecular and functional heterogeneity of niche cells within the developing endoderm could resolve mechanisms of tissue formation and maturation. Here, we discuss current unknowns in molecular mechanisms underlying key developmental events in pancreatic islet and intestinal epithelial formation. Recent breakthroughs in single‐cell and spatial transcriptomics, paralleled with functional studies in vitro, reveal that specialized mesenchymal subtypes drive the formation and maturation of pancreatic endocrine cells and islets via local interactions with epithelium, neurons, and microvessels. Analogous to this, distinct intestinal niche cells regulate both epithelial development and homeostasis throughout life. We propose how this knowledge can be used to progress research in the human context using pluripotent stem cell‐derived multilineage organoids. Overall, understanding the interactions between the multitude of microenvironmental cells and how they drive tissue development and function could help us make more therapeutically relevant in vitro models.

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Section: Pancreatic Niche Controls Plexus-to-duct Remodeling and Bran...mentioning

confidence: 99%

Deep into the niche: Deciphering local endoderm‐microenvironment interactions in development, homeostasis, and disease of pancreas and intestine

et al. 2023

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“…Interestingly, innervation is found most densely at the head of the pancreas and decreases toward the tail ( 17 ). The sympathetic system seems to develop during this early fetal period and may have a role in endocrine pancreas development ( 18 ). Understanding sympathetic innervation of the exocrine pancreas is in its infancy.…”

Section: Intrauterine Pancreas Developmentmentioning

confidence: 99%

Development of the human pancreas and its exocrine function

Mehta

Hopson²,

Smadi³

et al. 2022

Front. Pediatr.

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The pancreas has both endocrine and exocrine function and plays an important role in digestion and glucose control. Understanding the development of the pancreas, grossly and microscopically, and the genetic factors regulating it provides further insight into clinical problems that arise when these processes fail. Animal models of development are known to have inherent issues when understanding human development. Therefore, in this review, we focus on human studies that have reported gross and microscopic development including acinar-, ductal-, and endocrine cells and the neural network. We review the genes and transcription factors involved in organ formation using data from animal models to bridge current understanding where necessary. We describe the development of exocrine function in the fetus and postnatally. A deeper review of the genes involved in pancreatic formation allows us to describe the development of the different groups (proteases, lipids, and amylase) of enzymes during fetal life and postnatally and describe the genetic defects. We discuss the constellation of gross anatomical, as well as microscopic defects that with genetic mutations lead to pancreatic insufficiency and disease states.

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“…Our data also revealed an unexpected interaction between immature Schwann cells and endocrine progenitor cells, indicated by their close spatial proximity and we have proposed that this interaction may be required for endocrine progenitor maturation. 11 Indeed, extensive development of the sympathetic nervous system and neuronal interactions with endocrine progenitors have been observed in the developing human pancreas by immunohistochemistry 56 and neural crest cells, which are precursors of Schwann cells, are important in regulating beta cell maturation and mass in mice. 57 , 58 We also identified potential ligand‐receptor pairs by which the different cell types can potentially influence endocrine progenitors (Figure 2b ).…”

Section: Pancreatic Microenvironmentmentioning

confidence: 99%

Using single‐cell multi‐omics screening of human fetal pancreas to identify novel players in human beta cell development

2022

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Islet transplantation from organ donors can considerably improve glucose homeostasis and well‐being in individuals with type 1 diabetes, where the beta cells are destroyed by the autoimmune attack, but there are insufficient donor islets to make this a widespread therapy. Strategies are therefore being developed to generate unlimited amounts of insulin‐producing beta cells from pluripotent stem cells, with the aim that they will be transplanted to treat diabetes. Whilst much progress has been made in recent years in the directed differentiation of pluripotent stem cells to beta‐like cells, essential gaps still exist in generating stem cell‐derived beta cells that are fully functional in vitro. This short review provides details of recent multi‐‘omics’ studies of the human fetal pancreas, which are revealing granular information on the various cell types in the developing pancreas. It is anticipated that this fine mapping of the pancreatic cells at single‐cell resolution will provide additional insights that can be utilised to reproducibly produce human beta cells in vitro that have the functional characteristics of beta cells within native human islets.

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Prenatal development of sympathetic innervation of the human pancreas

Cited by 7 publications

References 54 publications

Deep into the niche: Deciphering local endoderm‐microenvironment interactions in development, homeostasis, and disease of pancreas and intestine

Deep into the niche: Deciphering local endoderm‐microenvironment interactions in development, homeostasis, and disease of pancreas and intestine

Development of the human pancreas and its exocrine function

Using single‐cell multi‐omics screening of human fetal pancreas to identify novel players in human beta cell development

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