2016
DOI: 10.1111/jog.13014
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Prenatal diagnosis and physical model reconstruction of agnathia–otocephaly with limb deformities (absent ulna, fibula and digits) following maternal exposure to oxymetazoline in the first trimester

Abstract: Agnathia-otocephaly or agnathia-sinotia-microstomy syndrome is the most severe malformation affecting the first branchial arch. It is a rare congenital anomaly characterized by absence of the lower jaw and abnormal ear positioning. Prenatal diagnosis is possible on conventional 2-D ultrasound in the second trimester. Three-dimensional ultrasound enhances detection of abnormal facial phenotype, especially in surface rendering mode. In addition, 3-D volume datasets are used to produce a physical model of the ano… Show more

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Cited by 11 publications
(6 citation statements)
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“…Also, this method is valid when there is no need to reconstruct internal bone structures such as presented in [ 17 19 ] where, to better study the case of different fetal pathologies, authors recommend to use procedures supplementing information from ultrasound images with information coming from CT and/or MRI scans.…”
Section: 3d Fetal Face Reconstruction Methodsmentioning
confidence: 99%
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“…Also, this method is valid when there is no need to reconstruct internal bone structures such as presented in [ 17 19 ] where, to better study the case of different fetal pathologies, authors recommend to use procedures supplementing information from ultrasound images with information coming from CT and/or MRI scans.…”
Section: 3d Fetal Face Reconstruction Methodsmentioning
confidence: 99%
“…Also, the use of 3D fetal printing is considered as a support for both physicians and parents. In fact, physicians may use 3D models reconstructed from ultrasound, CT, and/or MRI data sets, for the representation of specific pathologies that would prepare them for dealing with different clinical scenarios of the future newborn [ 17 19 ], while parents can get ready to receive their newborn more consciously.…”
Section: Introductionmentioning
confidence: 99%
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“…In animal models, agnathia otocephaly has been seen spontaneously in teratogen exposure e.g., irradiation, hyperthermia, trypan blue and streptonigrin [ 1 , 24 , 25 ]. Furthermore, case reports in humans have demonstrated cases of AOC associated to the exposure to salicylates, alcohol, radiation, oxymetazoline, mycophenolate, phenytoin, amidopyrine and beclomethasone [ 1 , 5 , 6 , 26 ].…”
Section: Discussionmentioning
confidence: 99%
“…They conclude that the physical 3D models allow greater interaction between the parent(s) and the fetus, as well as representing a method of continuing medical education. Since 2010, this research group has conducted a number of studies proposing the use of virtual and physical 3D models-based on data obtained with 3D-US, MRI, and CT-in the evaluation of various fetal malformations (11,14) , intrauterine infections (15,16) and maternal-fetal interaction in blind couples (17) . In all of those studies, the 3D models have allowed a better understanding of fetal disease by the medical team and by the parents, as well as enabling greater maternal-fetal interaction.…”
mentioning
confidence: 99%