“…In animal models, agnathia otocephaly has been seen spontaneously in teratogen exposure e.g., irradiation, hyperthermia, trypan blue and streptonigrin [ 1 , 24 , 25 ]. Furthermore, case reports in humans have demonstrated cases of AOC associated to the exposure to salicylates, alcohol, radiation, oxymetazoline, mycophenolate, phenytoin, amidopyrine and beclomethasone [ 1 , 5 , 6 , 26 ].…”