Prenatal diagnosis and postnatal management of congenital mesoblastic nephroma: Experience at a single center in China

Chen, Yanxiong; Huang, Chao; He, Qiuming; Wang, Zhe; Huang, Luyuan; Wang, Hai‐Yu; Mei, Shanshan; Chai, Chengwei; Zhang, Guanglan; Zhong, Wei; Li, Dong-Zhi

doi:10.1002/pd.5942

Cited by 4 publications

(4 citation statements)

References 22 publications

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“…Following abstract screening, 102 articles were determined to be outside the scope of the investigation and a further 14 full-text articles described cases of abdominal tumours without concomitant polyhydramnios. The remaining 27 publications describing 32 cases constituted the basis of this review ( Supplementary Table S1 ), [ 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 ].…”

Section: Resultsmentioning

confidence: 99%

Enlarged Abdominal Lymph Node as a Cause of Polyhydramnios in the Course of Congenital Neonatal Leukaemia: A Case Report and Review of the Literature on Foetal Abdominal Tumours with Coexisting Polyhydramnios

Salloum

Stanirowski

Symonides

et al. 2022

JCM

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Polyhydramnios represents a complication found in 0.2–2% of pregnancies, and it is usually diagnosed between 31 and 36 weeks of pregnancy. Although most cases of polyhydramnios are idiopathic, maternal diabetes or foetal malformations constitute frequent causes of the excessive accumulation of the amniotic fluid. Considering the latter, polyhydramnios may rarely be caused by foetal abdominal tumours, with the incidence rate of 2–14 cases per 100,000 live births. Congenital neonatal leukaemia (CNL) is a rare disease with a reported incidence rate of 5–8.6 cases per million live births. In the prenatal period, the ultrasound abnormalities associated with CNL include hepatomegaly and splenomegaly. In this paper, we presented a case of polyhydramnios caused by mechanical pressure on the foetal gastrointestinal tract by an enlarged lymph node in the course of CNL, as well as reviewing the available literature on foetal abdominal tumours with concurrent polyhydramnios.

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Section: Resultsmentioning

confidence: 99%

Enlarged Abdominal Lymph Node as a Cause of Polyhydramnios in the Course of Congenital Neonatal Leukaemia: A Case Report and Review of the Literature on Foetal Abdominal Tumours with Coexisting Polyhydramnios

Salloum

Stanirowski

Symonides

et al. 2022

JCM

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“…In a study by Chen et al, the perinatal characteristics of 11 CMN patients were retrospectively studied. The patients with CMN detected by prenatal ultrasound had an average gestational age of 35 weeks (25–39 weeks) ( 13 ). In our case, the renal mass was first seen at 33 weeks of gestational age and grew larger gradually.…”

Section: Discussionmentioning

confidence: 99%

“…Polyhydramnios occurs in 15%–36.4% of CMN cases, which increases the risk of premature birth. The cause of polyhydramnios may be high blood perfusion in the kidney and compression of the surrounding intestine ( 13 , 17 ). A foetus with CMN and oligohydramnios died one week after discovering the renal mass.…”

Section: Discussionmentioning

confidence: 99%

Prenatal diagnosis and postnatal management of congenital mesoblastic nephroma: A case report and literature review

Zhang

Wang

et al. 2022

Front. Pediatr.

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BackgroundCongenital mesoblastic nephroma (CMN) is a rare renal tumour in children, the most common kidney tumour in the neonatal period. It can be divided into three types, classical, cellular and mixed.Case presentationA 31-year-old Chinese woman had no apparent foetal abnormality in regular prenatal care during the first and second trimesters. At 33 weeks of gestation, a solid mass in the right kidney was noted with echoes similar to liver and hypervascularity. It grew larger during late pregnancy. The infant was transferred to have a radical nephrectomy on the 9th day after birth. The postoperative histopathological result indicated classical CMN.ConclusionCMN could be detected prenatally, mainly during late pregnancy. The postnatal outcome is good.

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“…CMN can be prenatally diagnosed by ultrasound and MRI. Several case/series reports of the prenatal diagnosis of CMN have been scatteringly published in the literature, and they are increasing in number [ 2 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 ]. However, to the best of our knowledge, the prenatal features and outcomes of pregnancies with fetal CMN have never been systematically reviewed and analyzed, whereas neonatal and pediatric series have been published several times.…”

Section: Introductionmentioning

confidence: 99%

Prenatal Course and Sonographic Features of Congenital Mesoblastic Nephroma

et al. 2022

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Background: Congenital mesoblastic nephroma (CMN) is the most common renal tumor among fetuses and infants before the age of 6 months. It usually behaves as a benign tumor. The prenatal features and outcomes of pregnancies with fetal CMN have never been systematically reviewed and analyzed, whereas neonatal or pediatric series have been published several times. The aims of this study are to (1) describe the prenatal natural course and prenatal sonographic char-acteristics of CMN; (2) determine the outcomes of pregnancies with fetal CMN; and (3) demonstrate typical sonographic images together with video clips of prenatal CMN, as an educational example based on our index case presented here. Methods: Studies focused on fetal CMN, including those consecutively published on PubMed from 1980 to June 2022 as well as the index case presented here, were identified and validated to perform a systematic review. The data of fetal imaging and the prenatal course of pregnancies were extracted for analysis. Results: The findings derived from 41 cases of review are as follows: (1) No single case has been diagnosed in the first half of pregnancy. No cases were detected during routine anomaly screening at mid-pregnancy. All cases were de-tected in the third trimester or late second trimester. (2) Polyhydramnios is very common and is the first clinical manifestation in most cases, leading to detailed ultrasound in the second half of pregnancy. (3) Preterm birth and low birth weight are the most common adverse pregnancy out-comes, resulting in neonatal morbidity. (4) Hydrops fetalis, though relatively rare, can be associated with CMN and is a grave sign. (5) Prenatal diagnosis is essential since it is critical for the antenatal plan, comprising either referral to a tertiary care center or proper surveillance to prevent serious obstetric complications, especially preterm birth. (6) Ultrasound is the primary tool for prenatal diagnosis of CMN, whereas MRI can be used as an adjunct if some other tumors are suspicious or sonographic features are not typical for CMN. Conclusion: In contrast to CMN in neonates, fetal CMN is much more serious since it significantly impacts adverse pregnancy outcomes and perinatal morbidity and mortality. The typical prenatal course and the sonographic features of CMN are described.

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Prenatal diagnosis and postnatal management of congenital mesoblastic nephroma: Experience at a single center in China

Cited by 4 publications

References 22 publications

Enlarged Abdominal Lymph Node as a Cause of Polyhydramnios in the Course of Congenital Neonatal Leukaemia: A Case Report and Review of the Literature on Foetal Abdominal Tumours with Coexisting Polyhydramnios

Enlarged Abdominal Lymph Node as a Cause of Polyhydramnios in the Course of Congenital Neonatal Leukaemia: A Case Report and Review of the Literature on Foetal Abdominal Tumours with Coexisting Polyhydramnios

Prenatal diagnosis and postnatal management of congenital mesoblastic nephroma: A case report and literature review

Prenatal Course and Sonographic Features of Congenital Mesoblastic Nephroma

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