Prenatal Diagnosis in France

Aymé, Ségolène; Morichon, Nicole; Goujard, J; Nisand, I.

doi:10.1159/000484812

Cited by 21 publications

(6 citation statements)

References 3 publications

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“…The triple test was an indication in 72 cases or 5% of all performed analyses which completely concurs with the observations of (8,9,11,12,13 (7,9,14,15,16 (3,17). During the period of six years, a positive ultrasound result as an indication was a means of foetal karyotype analysis in 24 cases, which is 1.7% of all analyses; in contrast, Webley and Halliday observed 20% and Chaabouni et al gave data of 8.2% of foetal karyotype analysis (9,12).…”

Section: Discussionsupporting

confidence: 87%

Justifiability of amniocentesis on the basis of positive findings of triple test, ultrasound scan and advanced maternal age

Bukvic¹,

Fanelli

Guanti

et al. 2011

AMA

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Objective. To assess the effectiveness of antenatal screening for chromosomal abnormalities based on maternal age (≥35 years), positive ultrasound findings or a positive triple test. Materials and methods. Retrospective six-year study. The pregnant women routinely underwent established clinical and laboratory practice at the Department of Medical Genetics between 1997 and 2003. The women's case notes were examined to identify indications for karyotyping, gestation period and the outcome of karyotyping and pregnancy. Results. Invasive antenatal tests were performed on 1440 cases, 1168 (81.11%) age 35(a), 72 (5.00%) positive triple test (b), 24 (1.67%) positive ultrasound scanning (c) and 176 (12.2%) other (psychological, personal reasons, etc) (d). The overall positive predictive value was 1.67% (1.6%(a), 1.4% (b), 12.5% (c), 0.0% (d). The constructed model of logistic regression gave an odds-ratio of 8.647 for the "positive ultrasound result vs. maternal age ≥35" indication, while the odds-ratio for the triple test vs. maternal age ≥35 was 0.854. Conclusions. Amniocentesis and cytogenetic analysis of foetal karyotype should be presented as a diagnostic possibility to all women over 35 years. The application of biochemical markers was far from the expected results. If we compare results for indication positive ultrasound scanning vs. maternal age, an oddsratio of ~9 was obtained. These results demonstrate that the likelihood of obtaining positive results (i.e. the presence of chromosome alterations) from an amniocentesis having this indication is almost 9 times higher than from having an amniocentesis performed solely for advanced maternal age.

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Section: Discussionsupporting

confidence: 87%

Justifiability of amniocentesis on the basis of positive findings of triple test, ultrasound scan and advanced maternal age

Bukvic¹,

Fanelli

Guanti

et al. 2011

AMA

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“…France pursues an active policy of antenatal surveillance, particularly for prenatal diagnosis of congenital anomalies 11,12 . Prenatal diagnosis of structural CHD with transabdominal ultrasonography began in the early 1980s and became widespread in the late 1980s 13 .…”

Section: Introductionmentioning

confidence: 99%

Trends in Prenatal Diagnosis, Pregnancy Termination, and Perinatal Mortality of Newborns With Congenital Heart Disease in France, 1983–2000: A Population-Based Evaluation

et al. 2005

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“…France pursues an active national prenatal testing policy, which is well codified and aims to provide reimbursed access to prenatal testing for all women. [18][19][20][21] Important changes have taken place in this policy over time, which has evolved from a programme essentially based on offer of amniocentesis for women 38 years of age or older to a regulated system of universal, reimbursed access to both ultrasound and maternal serum screening. Use of ultrasound screening has increased steadily since 1996 and it is now routinely offered for measurement of nuchal translucency.…”

Section: Introductionmentioning

confidence: 99%

Long‐term trends for socio‐economic differences in prenatal diagnosis of Down syndrome: diffusion of services or persistence of disparities?

Khoshnood

Vigan

Blondel

et al. 2008

BJOG

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Objective To assess long‐term trends in disparities for prenatal diagnosis of Down syndrome in relation to policy changes. Design Population‐based observational study. Setting Paris. Population Residents of Paris who gave birth or had a termination of pregnancy in Paris during 1983–2003 (approximately 23 000 births per year). Methods Using population‐based data from the Paris Registry of Congenital Malformations on 1934 cases of Down syndrome, we assessed differences in prenatal diagnosis proportions by maternal profession and geographical origin for the years 1983–2003. Analyses included locally weighted scatter plot smoother curves and binomial regression. Main outcome measure Trends in proportion of Down syndrome cases diagnosed prior to birth for different maternal occupation groups and women of different geographical origins. Results The proportion of prenatally diagnosed cases increased substantially, reaching to about 85–90% of cases in 2003 for most socio‐economic groups. This increase was accompanied by a significant decrease in disparities in prenatal diagnosis. Nonetheless, the proportion of prenatally diagnosed cases remained 12% lower for women without a profession compared with those in the highest occupational category (maternal age‐adjusted risk difference −12.0%, 95% CI −17.1 to −6.9). Conclusions Together with the implementation of policies aimed at providing access to prenatal screening for all women, socio‐economic differences in prenatal diagnosis of Down syndrome decreased over time. These trends need to be monitored, particularly in light of technical advances and alternative strategies for prenatal testing. However, while monitoring the proportion of cases with prenatal diagnosis is important, the ideal evaluation of prenatal testing programmes should also include measures of informed choice.

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Prenatal Diagnosis in France

Cited by 21 publications

References 3 publications

Justifiability of amniocentesis on the basis of positive findings of triple test, ultrasound scan and advanced maternal age

Justifiability of amniocentesis on the basis of positive findings of triple test, ultrasound scan and advanced maternal age

Trends in Prenatal Diagnosis, Pregnancy Termination, and Perinatal Mortality of Newborns With Congenital Heart Disease in France, 1983–2000: A Population-Based Evaluation

Long‐term trends for socio‐economic differences in prenatal diagnosis of Down syndrome: diffusion of services or persistence of disparities?

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