Prenatal diagnosis of congenital Wilms' tumor (nephroblastoma) presenting as fetal hydrops

Vadeyar, S.; Ramsay, Margaret M.; James, Deborah; O'Neill, David

doi:10.1046/j.1469-0705.2000.00169.x

Cited by 46 publications

(36 citation statements)

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“…Of these three deaths, two were attributed to hydrops and one to recurrence. [126] The cause of such rapid progression of disease in our patient is difficult to point but was probably due to the unusually aggressive tumor coupled with delayed presentation and lack of radiotherapy.…”

Section: Discussionmentioning

confidence: 91%

Is antenatal detection of Wilms′ tumor a bad prognostic marker?

Jain

Mohta

Sengar

et al. 2011

Indian Journal of Medical and Paediatric Oncology

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Antenatal detection of Wilms’ tumor is rare and only nine cases have been reported till now in the English literature. We report a case of a 7-month-old child with prenatally detected renal mass managed by nephroureterectomy associated with intraoperative spill. The child developed recurrence while on DD4A chemotherapy. Salvage chemotherapy was initiated but there was no response after two cycles and the child expired due to tumor rupture.

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Section: Discussionmentioning

confidence: 91%

Is antenatal detection of Wilms′ tumor a bad prognostic marker?

Jain

Mohta

Sengar

et al. 2011

Indian Journal of Medical and Paediatric Oncology

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“…Polyhydramnios has been described, but less often than in CMN. Rarely, WT may present with fetal hydrops [15] .…”

Section: Discussionmentioning

confidence: 99%

“…In addition, the technique provides more information with regard to adjacent organs and may define anomalies that could support an associated syndrome. MRI also better defines tumor relationship to the vessels [15] . The single case report of prenatal MRI of WT demonstrated a solid T 2 -hyperintense mass arising from the left kidney displacing but not invading adjacent structures.…”

Section: Discussionmentioning

confidence: 99%

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Contribution of Magnetic Resonance Imaging to Prenatal Differential Diagnosis of Renal Tumors: Report of Two Cases and Review of the Literature

Linam

Yu²,

Calvo-Garcia³

et al. 2010

Fetal Diagn Ther

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Enlargement of a kidney on prenatal imaging is usually due to hydronephrosis or cystic renal disease, and much less often results from solid tumors such as mesoblastic nephroma, Wilms’ tumor, nephroblastomatosis, renal sarcoma, and angiomyolipoma. All can be diagnosed by ultrasound. Magnetic resonance imaging is useful not only in confirming the presence of a renal mass, but also in the evaluation of the contralateral kidney for subtle abnormalities. We present one case each of Wilms’ tumor and mesoblastic nephroma, both detected on antenatal ultrasound and further studied with fetal magnetic resonance imaging.

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“…Moreover, childhood cancers have been associated with congenital anomalies in several studies (8)(9)(10). Proof-of-principle has been shown by case reports of prenatal diagnosis of several cancer types (11)(12)(13)(14)(15)(16)(17)(18)(19) and the detection of leukemic translocations in biospecimens taken at birth (20). The well-known association of vaginal clear-cell carcinoma with prenatal diethylstilbestrol exposure extends the observation of prenatal carcinogenesis to a diagnosis made primarily during young adulthood (21).…”

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confidence: 96%