Prenatal Diagnosis of Fetal Goitrous Hypothyroidism in a Euthyroid Mother: A Management Challenge

Aubry, Gabrielle; Pontvianne, M.; Chesnais, Marion; Weingertner, Anne Sophie; Guerra, Fernando; Favre, R.

doi:10.1002/jum.14275

Cited by 11 publications

(15 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Multiple causes must be considered in fetal neck masses investigation, such as cystic hygroma, teratoma, angioma, lymphangioma, and goiter, among others. Thus, imaging exams like US and, when not well clarified, fetal MRI assume a relevant role in clarifying the underlying cause [1, 6, 7]. After the fetal goiter diagnosis, initial assessment should include maternal medication or supplementation, iodine status, thyroid function, and autoimmune thyroid disorders (TSH, fT3, fT4, anti-TPO, anti-TG, and TSH receptor blocking antibodies) [1, 7].…”

Section: Discussionmentioning

confidence: 99%

“…Amniocentesis is better accepted by parents when both methods are proposed to assess fetal thyroid status. However, experts have expressed some doubts about accuracy and correlation between thyroid hormonal levels in amniotic fluid and fetal hormonal status [1, 6, 7].…”

Section: Discussionmentioning

confidence: 99%

“…It should be noticed that there is no consensus regarding who should be treated or when the treatment should be started, which hormone to use, appropriate dose, number of administrations, and the interval between them [1, 7]. Treatment is controversial because this pathology is rare and there are few published cases reviews.…”

Section: Discussionmentioning

confidence: 99%

“…It can be associated with fetal hyperthyroidism and hypothyroidism and even rarely with euthyroid status. Congenital hypothyroidism (CH) is the most frequent congenital endocrine disorder and an usual and preventable cause of intellectual disability [1–3]. The most common cause of CH is thyroid dysgenesis (agenesis, hypoplasia, or ectopy) and only 15-20% is due to specific errors in thyroid hormones synthesis-dyshormonogenesis, which is usually hereditary with autosomal recessive inheritance [2, 4].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Prenatal Diagnosis and Management of a Fetal Goiter Hypothyroidism due to Dyshormonogenesis

Figueiredo

Falcão

Vilaverde

et al. 2018

Case Reports in Endocrinology

View full text Add to dashboard Cite

Fetal goiter is a rare disorder not expected to be found during a healthy woman's pregnancy. It can be a prenatal manifestation of congenital hypothyroidism due to thyroid dyshormonogenesis and it can lead to serious perinatal complications. A vascularized fetal neck mass was detected at 29 weeks' gestation of a healthy primigravida. Magnetic resonance was suggestive of goiter causing airway deviation without polyhydramnios. Maternal thyroid function was normal and thyroid antibodies were negative. Two intra-amniotic levothyroxine infusions were performed at 32 and 33 weeks. Serial imaging control showed no progression of the mass. Elective caesarean section was performed at 38 weeks. The male newborn was admitted to the intensive care unit due to cardiorespiratory insufficiency with pulmonary hypertension. Hormonal assays revealed primary congenital hypothyroidism and ultrasonography confirmed diffuse goiter. Levothyroxine was started. Currently, he is 6 years old with adequate growth and normal psychomotor development. Genetic study found a heterozygous mutation in the TPO gene.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Prenatal Diagnosis and Management of a Fetal Goiter Hypothyroidism due to Dyshormonogenesis

Figueiredo

Falcão

Vilaverde

et al. 2018

Case Reports in Endocrinology

View full text Add to dashboard Cite

show abstract

“…Fetal goiter can cause fetal, obstetric, and neonatal complications including polyhydramnios secondary to reduced swallowing ability, cervical dystocia, and mechanical obstruction of the fetal airway respectively [ 58 , 66 , 67 ]. Cesarean delivery may be preferred due to high risk of labor dystocia from a deflexed head [ 68 ].…”

Section: Introductionmentioning

confidence: 99%

Graves’ hyperthyroidism in pregnancy: a clinical review

Nguyen

Sasso

Barton

et al. 2018

Clin Diabetes Endocrinol

View full text Add to dashboard Cite

BackgroundGraves’ hyperthyroidism affects 0.2% of pregnant women. Establishing the correct diagnosis and effectively managing Graves’ hyperthyroidism in pregnancy remains a challenge for physicians.MainThe goal of this paper is to review the diagnosis and management of Graves’ hyperthyroidism in pregnancy. The paper will discuss preconception counseling, etiologies of hyperthyroidism, thyroid function testing, pregnancy-related complications, maternal management, including thyroid storm, anti-thyroid drugs and the complications for mother and fetus, fetal and neonatal thyroid function, neonatal management, and maternal post-partum management.ConclusionEstablishing the diagnosis of Graves’ hyperthyroidism early, maintaining euthyroidism, and achieving a serum total T4 in the upper limit of normal throughout pregnancy is key to reducing the risk of maternal, fetal, and newborn complications. The key to a successful pregnancy begins with preconception counseling.

show abstract

Intra‐amniotic levothyroxine infusions in a case of fetal goiter due to novel Thyroglobulin gene variants

Pollé

Gheldof²,

Lysy

et al. 2021

Clinical Case Reports

View full text Add to dashboard Cite

show abstract

Prenatal Diagnosis of Fetal Goitrous Hypothyroidism in a Euthyroid Mother: A Management Challenge

Cited by 11 publications

References 43 publications

Prenatal Diagnosis and Management of a Fetal Goiter Hypothyroidism due to Dyshormonogenesis

Prenatal Diagnosis and Management of a Fetal Goiter Hypothyroidism due to Dyshormonogenesis

Graves’ hyperthyroidism in pregnancy: a clinical review

Intra‐amniotic levothyroxine infusions in a case of fetal goiter due to novel Thyroglobulin gene variants

Contact Info

Product

Resources

About