Prenatal diagnosis of fetal hypothyroidism after maternal radioactive iodine exposure during pregnancy

Başbuğ, Mustafa; Özgün, Mahmut Tuncay; Murat, N.; Batukan, Cem; Özçelik, Bülent; Kurtoğlu, Selim

doi:10.1002/jcu.20737

Cited by 4 publications

(3 citation statements)

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“…Rarely, thyroidectomy can also be an option, but RAI is contraindicated (9). RAI is not used in known pregnancies, but its use in undetected pregnancies is rarely reported (1,6). RAI given to a pregnant woman crosses the placenta rapidly and reaches the fetus (10).…”

Section: Discussionmentioning

confidence: 99%

“…If a woman who has received RAI therapy is later detected to be pregnant, fetal thyroid function tests should be undertaken and prenatal treatment should be initiated (6). …”

Section: Discussionmentioning

confidence: 99%

“…The use of I131 is absolutely contraindicated during pregnancy principally because of the risk of damaging the fetal thyroid gland and thus leading to hypothyroidism or cretinism (1,2,3,4,5,6). Neonatal hyperthyrotropinemia is observed if the applieddose is below 10 mCi (7).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Congenital Hypothyroidism Due To Maternal Radioactive Iodine Exposure During Pregnancy

Kurtoğlu¹,

Akın²,

Daar³

et al. 2012

JCRPE

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Radioactive iodine (RAI) is used effectively in the treatment of hyperthyroidism and thyroid cancer, but it is contraindicated during pregnancy. RAI treatment during pregnancy can lead to fetal hypothyroidism, mental retardation and increased malignancy risk in the infant. Pregnancy tests must be performed before treatment in all women of reproductive age. However, at times, RAI is being used before ruling out pregnancy.We herein present a male newborn infant with congenital hypothyroidism whose mother was given a three-week course of methimazole therapy for her multiple hyperactive nodules and subsequently received 20 mCi RAI during the 12th week of her pregnancy. The patient was referred to our neonatology unit at age two weeks when his thyrotropin (TSH) level was reported to be high in the neonatal screening test. Physical examination was normal. Laboratory investigations revealed hypothyroidism (free triiodothyronine 1.55 pg/mL, free thyroxine 2.9 pg/mL, TSH 452 mU/L, thyroglobulin 20.1 ng/mL). The thyroid gland could not be visualized by ultrasonography. L-thyroxine treatment was initiated. Conflict of interest:None declared.

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Section: Discussionmentioning

confidence: 99%

“…If a woman who has received RAI therapy is later detected to be pregnant, fetal thyroid function tests should be undertaken and prenatal treatment should be initiated (6). …”

Section: Discussionmentioning

confidence: 99%