Prenatal Diagnosis of Hydro(metro)colpos: A Series of 20 Cases

Abstract

Background: Hydrocolpos and hydrometrocolpos are rare malformations caused by accumulation of secretion due to congenital obstruction of the vagina. Hydro(metro)colpos may be isolated or can be combined with other malformations as part of a syndromic disorder. We report on a series of 20 cases with hydro(metro)colpos diagnosed prenatally, delineate the differential diagnoses, and illustrate the spectrum of associated malformations. Subjects and Methods: This was a retrospective study involving 20 fetuses with hydro(metro)colpos at two large tertiary referral centers in Germany over an 18-year period (2000–2017). Results: The median diagnosis was made at 30⁺⁴ weeks of gestation, the earliest at 20⁺⁶ weeks, the latest at 37⁺² weeks. All 20 fetuses presented with the typical cystic structure behind the fetal bladder. Additional malformations included urogenital malformations, hexadactyly, and heart defects. Postnatal follow-up revealed that hydro(metro)colpos was associated with anorectal malformation in 11/20 fetuses, McKusick-Kaufman syndrome or Bardet-Biedl syndrome in 4/20 fe tuses, Mayer-Rokitansky-Küster-Hauser syndrome in 3/20 fetuses, and Herlyn-Werner-Wunderlich syndrome in 1/20. In 1 fetus pressure from an intraabdominal teratoma resulted in prenatal hydro(metro)colpos. Conclusion: Hydro(me tro)colpos is a rare prenatal sonographic feature. Multidisciplinary prenatal counseling should include all potential syndromes that can present with hydro(metro)colpos in the prenatal setting.

Síndrome de Herlyn-Werner-Wunderlich: reporte de caso y revisión de la literatura

“…Posteriormente, nueve estudios fueron excluidos por no tener acceso al texto completo; finalmente, se incluyeron 74 publicaciones que cumplieron con los criterios de inclusión (Tabla 1). En las 74 publicaciones incluidas se encontraron 6 estudios observacionales retrospectivos (4, 13-17), 10 series de casos (10)(11)(18)(19)(20)(21)(22)(23)(24)(25) y 58 reportes de caso (12,, que incluyeron un total de 663 pacientes. La mayoría de las publicaciones fueron en India con 11 estudios (17,29,39,(44)(45)(46)(47)52,60,62,63), seguido de USA con 9 estudios (30,32,53,56,69,70,72,75,78), China (10,11,13,15,24,25,33,67) e It alia (4,20,23,34,37,51,66,…”

“…La población incluida presenta una edad media al diagnóstico de 16,8 años (0 a 53 años). Un reporte de caso de diagnóstico ecográfico antenatal (54), 4 de diagnóstico neonatal (22,26,38,50), 12 entre 1 y 12 años (28,37,48,51 ,52,59,61,66,73,78,80,82), 26 entre 13 y 19 años (27,29,30,32,39,41,42,(44)(45)(46)(47)49,55,56,58,60,63,(68)(69)(70)(71)(72)74,76,77,79) y 15 reportes de mayores de 20 años (31,(33)(34)(35)(36)40,43,53,57,62,64,65,67,75,81).…”

Effectiveness of Prenatal Intervention on the Outcome of Diseases That Have a Postnatal Urological Impact

“…A retrovesical cystic mass in a female fetus usually represent a Mullerian structure filled with fluid. Mallman et al reported 20 cases which illustrate the spectrum of differential diagnoses, associated malformations and possible course of action (30). Most of the cases were detected in the late ultrasound screening, and only one in the second semester screening (median gestational age at diagnosis 30 weeks).…”

Hydrometrocolpos in Infants: Etiologies and Clinical Presentations

“…HMC can sometimes be part of several syndromes. One case series [12] [18,19], and renal, skeletal, ear, and cardiac malformations of Mayer-Rokitansky-Küster-Hauser syndrome [20,21]. It is difficult to distinguish McKusick Kaufman syndrome and Bardet-Biedl syndrome in the neonatal period.…”