Prenatal diagnosis of persistent left superior vena cava: a retrospective study of associated congenital anomalies

Özsürmeli, Mehmet; Büyükkurt, Selim; Sucu, Mete; Arslan, Erol; Akçabay, Çiğdem; Misirlioğlu, Seli̇m; Kayapınar, Masum; Özbarlas, Nazan; Demir, Süleyman Cansun; Evrüke, Cüneyt

doi:10.4274/tjod.galenos.2019.02679

Cited by 8 publications

(4 citation statements)

References 17 publications

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“…It is difficult to estimate the occurrence of abnormalities associated with the prenatal diagnosis of single LSVC (absent RSVC) from isolated case reports, some describing association with significant abnormalities and others with single LSVCs [14][15][16][17][18]. In this small series, 14 cases of prenatal detection of a single LSVC correspond to 0.07% of patients undergoing fetal echocardiography.…”

Section: Discussionmentioning

confidence: 87%

“…Prenatal detection of a single LSVC has been rare, and previous publications are limited to case reports of 1-5 patients [14,17]. O ¨zsu ¨rmeli reported a series of 32 cases of prenatal diagnosis of persistent LSVC, all but one had bilateral SVCs [18]. Three other series include 325 combined patients with a prenatal diagnosis of persistent LSVC with no cases of absent RSVC noted [4,19,20].…”

Section: Discussionmentioning

confidence: 99%

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Prenatal Diagnosis of Absent Right Superior Vena Cava in Referrals for Fetal Echocardiography

Acherman

Evans

Restrepo

2021

Journal of Fetal Medicine

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A persistent LSVC with an absent right superior vena cava (RSVC) is unusual, encountered in about 10% of patients with persistent LSVC. We present 14 patients with a prenatal diagnosis of single LSVC and situs solitus, including prenatal findings and information on medium-term follow-up. We identified patients with situs solitus and a persistent LSVC born between March 2004 and March 2020, which had been diagnosed prenatally between December 2003 and November 2019. From this cohort, we identified those with absent RSVC. In the population of women undergoing fetal echocardiography, the prevalence of persistent LSVC in situs solitus was 0.43% (84/19,712). For the 84 identified patients and for the entire population respectively, 14/84 (17%) and 14/19,712 (0.07%) had a single LSVC (absent RSVC). Of 14 patients with a single LSVC, 8 (57%) were male. For the 84 identified patients and for the entire population respectively, 70/84 (83%) and 70/19,712 (0.36%) had bilateral SVCs. For a single LSVC (absent RSVC) and situs solitus, the majority had no associated cardiac, extracardiac, or syndromic abnormalities.

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Prenatal Diagnosis of Absent Right Superior Vena Cava in Referrals for Fetal Echocardiography

Acherman

Evans

Restrepo

2021

Journal of Fetal Medicine

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“…The fetus with PLSVC is often associated with intra-cardiac and/or extra-cardiac anomalies. Ventricular septal defect, endocardial cushion defect and tetralogy of Fallot are common intra-cardiac malformations, while single umbilical artery is a common extra-cardiac malformation (Berg et al, 2006 ). Intra-cardiac and/or extra-cardiac anomalies in our patient were demonstrated by ventricular septal defect and single umbilical artery.…”

Section: Discussionmentioning

confidence: 99%

Case Report: Candidate Genes Associated With Prenatal Ultrasound Anomalies in a Fetus With Prenatally Detected 1q23.3q31.2 Deletion

et al. 2021

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Background: Patients with deletions involving the long arm of chromosome 1 are rare, and the main aim of this study was to refine the genotype-phenotype correlation.Case Report: In this report, a 28-year-old pregnant woman, gravida 2 para 1, at 25+4 weeks of gestation underwent ultrasound examination in our institute. The ultrasonographic findings of the fetus were as follows: (1) fetal growth restriction; (2) cleft lip and palate; (3) bilateral renal hypoplasia; (4) lateral ventriculomegaly; (5) single umbilical artery; (6) absent stomach; (7) coronary sinus dilatation with persistent left superior vena cava, ventricular septal defect and unroofed coronary sinus syndrome. Chromosomal microarray analysis of amniotic fluid from the fetus revealed a 28.025 Mb deletion in 1q23.3q31.2, spanning from position 164,559,675 to 192,584,768 (hg19).Conclusion: Genotype-phenotype correlation might improve prenatal diagnosis of fetuses with chromosome 1q deletion. PBX1 could be a candidate gene for fetal growth restriction, renal hypoplasia and congenital heart disease. Fetal growth restriction was accompanied by decreased renal volume in the fetus. Combined with ultrasonic examination, the application of chromosomal microarray analysis will provide accurate prenatal diagnosis.

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“…Persistent left superior vena cava (PLSVC) is a frequent congenital heart anomaly reported in 0.3-0.5% of the general population. Generally, is a benign finding, without hemodynamic consequences, but its association with congenital heart diseases (CHD) in 4-8% is significant and requires a detailed prenatal cardiac evaluation and a systematic follow-up of the apparently isolated PLSVC to exclude unfavorable outcomes [1,2]. Cardio-vascular system development starts early in embryonic life, and around the 23rd day the primitive heart starts beating.…”

Section: Introductionmentioning

confidence: 99%

Persistent Left Superior Vena Cava Significance in Prenatal Diagnosis—Case Series

Poenaru

Hamoud

Sima

et al. 2022

JCM

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The persistent left superior vena cava (PLSVC) is a congenital heart anomaly reported in 0.3–0.5% of the general population and can be associated with congenital heart diseases in up to 8% of cases. Prenatal identification of PLSVC is important to prompt an extended cardiac and extracardiac fetal examination. We retrospectively reevaluated anomaly scans performed in our unit in a 2-year interval according to the national guidelines to evaluate the incidence of PLSVC and its association with prenatal morbidity. In our population, the incidence of PLSVC was 0.31%, and we found a low association with cardiac and extracardiac anomalies. The standard sections (three-vessel and trachea view, four-chamber view and outflow tract’s view) are insufficient to exclude cardiac anomalies whenever PLSVC is found. In our case series, only one newborn required postnatal surgery for total pulmonary vein anomaly, and at 2 years of life all babies had a normal evolution. Prenatal diagnosis of PLSVC can raise counseling issues; therefore, awareness of its good outcome when isolated and need for an extended examination to rule out other anomalies is very important.

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Prenatal diagnosis of persistent left superior vena cava: a retrospective study of associated congenital anomalies

Cited by 8 publications

References 17 publications

Prenatal Diagnosis of Absent Right Superior Vena Cava in Referrals for Fetal Echocardiography

Prenatal Diagnosis of Absent Right Superior Vena Cava in Referrals for Fetal Echocardiography

Case Report: Candidate Genes Associated With Prenatal Ultrasound Anomalies in a Fetus With Prenatally Detected 1q23.3q31.2 Deletion

Persistent Left Superior Vena Cava Significance in Prenatal Diagnosis—Case Series

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