Prenatal diagnosis of portal vein thrombosis by ultrasound

Stiller, Robert J.; Neale, Donna M; Schwartz, Dana; Laifer, Steven A.; Kleinman, G

doi:10.1002/uog.216

Cited by 15 publications

(9 citation statements)

References 11 publications

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“…One older case study from 1998 was incorporated because of the unique, descriptive information provided, resulting in a total of 72 available publications for data assessment. Following critical appraisal of the resources and selection criteria, 19 were retained (Table ) . All of the publications over the 19 years were case reports or case series.…”

Section: Resultsmentioning

confidence: 99%

“…Following critical appraisal of the resources and selection criteria, 19 were retained (Table 4). 2,4,6,12,[16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] All of the publications over the 19 years were case reports or case series. Excluded articles were either nonspecific to PVT, did not include any specific case scenarios (infants or neonates were not individually identifiable or combined with results of children), failed to meet age criteria or did not specify ages of the subjects or did not specifically discuss the use of ACT.…”

Section: Resultsmentioning

confidence: 99%

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Outcomes following neonatal portal vein thrombosis: A descriptive, single‐center study and review of anticoagulant therapy

Bhatt

Patel

Butt

et al. 2018

Pediatric Blood & Cancer

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Background Neonatal portal vein thrombosis (PVT) is uncommon with potentially serious complications that may manifest in infancy and childhood. Objective The primary aim of our study was to describe the short‐term and long‐term outcomes of neonatal PVT. Methods A retrospective chart review was conducted from 2008 to 2016 of neonates diagnosed with PVT. A systematic review was also performed from 2000 to 2018 to evaluate anticoagulant therapy (ACT) in neonatal PVT. Results Forty‐four premature and 30 term infants (mean gestational age 30.7 vs 39.1 weeks, respectively) had PVT. Sixty‐eight involved the left portal vein, one involved only the main portal vein, and 5 involved ≥1 vein. PVT was catheter associated in 46 (62%); none of the 7 neonates tested had thrombophilia. Of 74 neonates, 19 (26%) received ACT and 55 (74%) were untreated. The mean follow‐up duration was 16.6 months (SD = 17.62; range, 0–89.6); 59.5% were followed for ≥6 months. On last ultrasound examination, thrombus resolution was documented in treated (ACT; n = 19) and nontreated (n = 55) neonates: 12 (63%) versus 32 (58%) with complete resolution, 1 (5%) versus 6 (11%) partial, 0 versus 1 (2%) extension, and 6 (32%) versus 16 (29%) had nonprogressive lesions, respectively. Seventy‐one (96%) had no complications. Seventy‐one articles met inclusion criteria for the systematic review and 19 were retained for analysis after assessment. Conclusions PVT resolution rate was similar to previous reports. Although a low complication rate was detected, longer follow‐up is necessary to determine the need for early treatment and the precise incidence of outcomes such as portal hypertension.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Outcomes following neonatal portal vein thrombosis: A descriptive, single‐center study and review of anticoagulant therapy

Bhatt

Patel

Butt

et al. 2018

Pediatric Blood & Cancer

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“…Possible etiologies could include inherited thrombophilias, maternal disease that is prothrombotic, and anatomic variations altering blood flow. One case of fetal portal vein thrombosis of undetermined etiology diagnosed via antenatal ultrasonography has been reported, 8 along with several cases of fetal renal and inferior vena cava thrombosis. We know of no known reported cases of fetal venous thromboses related to the in utero withdrawal of renin-angiotensin system inhibiting agents.…”

Section: Commentmentioning

confidence: 98%

In Utero Losartan Withdrawal and Subsequent Development of Fetal Inferior Vena Cava Thrombosis

Bakkum¹,

Brost

Johansen³

et al. 2006

Obstetrics &Amp; Gynecology

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“…Intrahepatic umbilical vein dilatation has been reported as an early, indirect sign of fetal portal vein thrombosis [17] .…”

Section: Discussionmentioning

confidence: 99%

Call for Caution: Neonatal Portal Vein Thrombosis following Enbucrilate Embolization of Placental Chorioangioma

Voon

Amin²,

Kok³

et al. 2017

Fetal Diagn Ther

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We illustrate a case of giant placental chorioangioma presenting at 20 weeks of gestation. Subsequent monitoring revealed enlargement of the lesion, associated with fetal anemia and cardiac failure, prompting in utero intervention. Amnioreduction followed by percutaneous embolization of the tumour with enbucrilate:Lipiodol Ultra-Fluid™ at a dilution of 1:5 was successfully performed. No repeat intervention or additional supportive measures were required throughout pregnancy and the baby was delivered at 36 weeks of gestation, following spontaneous labour. Due to prolonged neonatal jaundice, further investigations were undertaken, demonstrating subacute right portal vein thrombosis. Other previously reported causes of neonatal portal vein thrombosis such as umbilical vein thrombosis, neonatal umbilical vein catheterization, thrombophilia and sepsis were excluded. There was resolution of the thrombus by 6 months of life. A brief discussion of measures to minimize the risk of such an event and the long-term outcomes of neonatal portal vein thrombosis was included. Whilst the simplicity and efficacy of the procedure has been demonstrated in a handful of patients, judgment on its safety is best deferred. Counselling should be comprehensive, as even rare complications can result in significant postnatal morbidity.

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Prenatal diagnosis of portal vein thrombosis by ultrasound

Abstract: Neonatal portal vein thrombosis (PVT) is

Cited by 15 publications

References 11 publications

Outcomes following neonatal portal vein thrombosis: A descriptive, single‐center study and review of anticoagulant therapy

Outcomes following neonatal portal vein thrombosis: A descriptive, single‐center study and review of anticoagulant therapy

In Utero Losartan Withdrawal and Subsequent Development of Fetal Inferior Vena Cava Thrombosis

Call for Caution: Neonatal Portal Vein Thrombosis following Enbucrilate Embolization of Placental Chorioangioma

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