Prenatal dietary exposure to chemicals and allergy or respiratory diseases in children in the EDEN mother–child cohort

Ghozal, Manel; Kadawathagedara, Manik; Delvert, Rosalie; Adel-Patient, Karine; Tafflet, Muriel; Annesi-Maesano, Isabella; Crépet, Amélie; Sirot, Véronique; Charles, Marie Aline; Heude, Barbara; de Lauzon-Guillain, Blandine

doi:10.1016/j.envint.2023.108195

Cited by 8 publications

(4 citation statements)

References 63 publications

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“…In the LaSalle EUC Retrospective Mortality Cohort, prenatal exposure to PCBs was positively associated with the risk of eczema up to 10 years [ 46 ]. In the EDEN mother-child cohort, prenatal dietary exposure to the mixture TE-F-PAH was associated with higher risk of allergic rhinitis but not with eczema, and none of the other mixtures was associated with allergic or respiratory diseases up to 8 years [ 21 ]. In our study, we did not examine associations with allergic rhinitis because it was not collected in the ELFE study before age of 5.5 years, and 5 years of age is too early to properly examine allergic rhinitis [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

“…In the Eden mother-child cohort, eight mixtures of chemicals were identified from maternal dietary exposure in pregnancy using sparse non-negative matrix underapproximation (SNMU) [ 62 ]. We previously reported a positive association between prenatal dietary exposure to a mixture composed mainly by trace elements, furans and PAHs and allergic rhinitis up to 8 years [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

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Prenatal dietary exposure to mixtures of chemicals is associated with allergy or respiratory diseases in children in the ELFE nationwide cohort

Ghozal,

Kadawathagedara,

Delvert

et al. 2024

Environ Health

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Introduction Prenatal exposure to environmental chemicals may be associated with allergies later in life. We aimed to examine the association between prenatal dietary exposure to mixtures of chemicals and allergic or respiratory diseases up to age 5.5 y. Methods We included 11,638 mother-child pairs from the French “Étude Longitudinale Française depuis l’Enfance” (ELFE) cohort. Maternal dietary exposure during pregnancy to eight mixtures of chemicals was previously assessed. Allergic and respiratory diseases (eczema, food allergy, wheezing and asthma) were reported by parents between birth and age 5.5 years. Associations were evaluated with adjusted logistic regressions. Results are expressed as odds ratio (OR[95%CI]) for a variation of one SD increase in mixture pattern. Results Maternal dietary exposure to a mixture composed mainly of trace elements, furans and polycyclic aromatic hydrocarbons (PAHs) was positively associated with the risk of eczema (1.10 [1.05; 1.15]), this association was consistent across sensitivity analyses. Dietary exposure to one mixture of pesticides was positively associated with the risk of food allergy (1.10 [1.02; 1.18]), whereas the exposure to another mixture of pesticides was positively but slightly related to the risk of wheezing (1.05 [1.01; 1.08]). This last association was not found in all sensitivity analyses. Dietary exposure to a mixture composed by perfluoroalkyl acids, PAHs and trace elements was negatively associated with the risk of asthma (0.89 [0.80; 0.99]), this association was consistent across sensitivity analyses, except the complete-case analysis. Conclusion Whereas few individual chemicals were related to the risk of allergic and respiratory diseases, some consistent associations were found between prenatal dietary exposure to some mixtures of chemicals and the risk of allergic or respiratory diseases. The positive association between trace elements, furans and PAHs and the risk of eczema, and that between pesticides mixtures and food allergy need to be confirmed in other studies. Conversely, the negative association between perfluoroalkyl acids, PAHs and trace elements and the risk of asthma need to be further explored.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prenatal dietary exposure to mixtures of chemicals is associated with allergy or respiratory diseases in children in the ELFE nationwide cohort

Ghozal,

Kadawathagedara,

Delvert

et al. 2024

Environ Health

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“…Interesting results regarding the correlation between prenatal dietary exposure to different food components, mainly chemicals, and the risk of allergic diseases came from a very recently published, large cohort study involving 1248 mother-child pairs observed up to 8 years of age. Prenatal dietary exposure to resveratrol was associated with a lower risk of both wheezing and allergic rhinitis, while most tested food chemicals increased the risk of asthma, wheezing, and allergic rhinitis [70].…”

Section: Evidence From Epidemiological Studiesmentioning

confidence: 95%

Dietary Polyphenols—Natural Bioactive Compounds with Potential for Preventing and Treating Some Allergic Conditions

Dębińska,

Sozańska

2023

Nutrients

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In light of the constantly increasing prevalence of allergic diseases, changes in dietary patterns have been suggested as a plausible environmental explanation for the development and progression of these diseases. Nowadays, much attention has been paid to the development of dietary interventions using natural substances with anti-allergy activities. In this respect, dietary polyphenols have been studied extensively as one of the most prominent natural bioactive compounds with well-documented anti-inflammatory, antioxidant, and immunomodulatory properties. This review aims to discuss the mechanisms underlying the potential anti-allergic actions of polyphenols related to their ability to reduce protein allergenicity, regulate immune response, and gut microbiome modification; however, these issues need to be elucidated in detail. This paper reviews the current evidence from experimental and clinical studies confirming that various polyphenols such as quercetin, curcumin, resveratrol, catechins, and many others could attenuate allergic inflammation, alleviate the symptoms of food allergy, asthma, and allergic rhinitis, and prevent the development of allergic immune response. Conclusively, dietary polyphenols are endowed with great anti-allergic potential and therefore could be used either for preventive approaches or therapeutic interventions in relation to allergic diseases. Limitations in studying and widespread use of polyphenols as well as future research directions are also discussed.

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“…The study found that for every additional 10 g of olive oil consumed per day, the risk of asthma decreased by an additional 20% [ 55 ]. In another study, exposure to resveratrol in the diet during pregnancy was linked to a reduced likelihood of experiencing wheeze and allergic rhinitis [ 56 ].…”

Section: The Influence Of Diet and Nutritional Status On Allergic Rea...mentioning

confidence: 99%

Dietary Polyphenols, Plant Metabolites, and Allergic Disorders: A Comprehensive Review

Farhan,

Rizvi,

Aatif

et al. 2024

Pharmaceuticals

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Given the ongoing rise in the occurrence of allergic disorders, alterations in dietary patterns have been proposed as a possible factor contributing to the emergence and progression of these conditions. Currently, there is a significant focus on the development of dietary therapies that utilize natural compounds possessing anti-allergy properties. Dietary polyphenols and plant metabolites have been intensively researched due to their well-documented anti-inflammatory, antioxidant, and immunomodulatory characteristics, making them one of the most prominent natural bioactive chemicals. This study seeks to discuss the in-depth mechanisms by which these molecules may exert anti-allergic effects, namely through their capacity to diminish the allergenicity of proteins, modulate immune responses, and modify the composition of the gut microbiota. However, further investigation is required to fully understand these effects. This paper examines the existing evidence from experimental and clinical studies that supports the idea that different polyphenols, such as catechins, resveratrol, curcumin, quercetin, and others, can reduce allergic inflammation, relieve symptoms of food allergy, asthma, atopic dermatitis, and allergic rhinitis, and prevent the progression of the allergic immune response. In summary, dietary polyphenols and plant metabolites possess significant anti-allergic properties and can be utilized for developing both preventative and therapeutic strategies for targeting allergic conditions. The paper also discusses the constraints in investigating and broad usage of polyphenols, as well as potential avenues for future research.

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Prenatal dietary exposure to chemicals and allergy or respiratory diseases in children in the EDEN mother–child cohort

Cited by 8 publications

References 63 publications

Prenatal dietary exposure to mixtures of chemicals is associated with allergy or respiratory diseases in children in the ELFE nationwide cohort

Prenatal dietary exposure to mixtures of chemicals is associated with allergy or respiratory diseases in children in the ELFE nationwide cohort

Dietary Polyphenols—Natural Bioactive Compounds with Potential for Preventing and Treating Some Allergic Conditions

Dietary Polyphenols, Plant Metabolites, and Allergic Disorders: A Comprehensive Review

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