Prenatal Environmental Exposure to Persistent Organic Pollutants and Indices of Overweight and Cardiovascular Risk in Dutch Adolescents

Berghuis, Sietske A.; Bos, Arend F.; Sauer, Pieter; Bocca, Gianni

doi:10.3390/nu14112269

Cited by 10 publications

(4 citation statements)

References 48 publications

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“…BWQS regressions were stratified by sex due to potential sex-specific effects of some EDCs. [35][36][37] We note that sex interactions were not tested due to the absence of interaction testing functions in the BWQS package. Sensitivity analyses to ensure results robustness included (1) single-exposure analyses using linear regressions, correcting for multiple testing with false discovery rate (FDR) and assessment of between-cohort heterogeneity using the I 2 statistic of association 38 ; (2) mixture analyses for lipophilic compounds, stratifying mothers by gestational weight gain according to the Institute of Medicine guidelines 39 ; (3) phthalate mixture analysis, incorporating molar sums of DEHP and DiNP metabolites; (4) metal and persistent mixture analysis, including sum of PCBs, and nonpersistent mixture analysis, incorporating molar sums of DEHP, DiNP, and parabens; and (5) testing main significant mixture associations with a binarized MetS risk outcome, using the 80th percentile as the cutoff.…”

Section: Discussionmentioning

confidence: 99%

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Prenatal Exposure to Chemical Mixtures and Metabolic Syndrome Risk in Children

Güil-Oumrait,

Stratakis,

Maitre

et al. 2024

JAMA Netw Open

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ImportancePrenatal exposure to ubiquitous endocrine-disrupting chemicals (EDCs) may increase the risk of metabolic syndrome (MetS) in children, but few studies have studied chemical mixtures or explored underlying protein and metabolic signatures.ObjectiveTo investigate associations of prenatal exposure to EDC mixtures with MetS risk score in children and identify associated proteins and metabolites.Design, Setting, and ParticipantsThis population-based, birth cohort study used data collected between April 1, 2003, and February 26, 2016, from the Human Early Life Exposome cohort based in France, Greece, Lithuania, Norway, Spain, and the UK. Eligible participants included mother-child pairs with measured prenatal EDC exposures and complete data on childhood MetS risk factors, proteins, and metabolites. Data were analyzed between October 2022 and July 2023.ExposuresNine metals, 3 organochlorine pesticides, 5 polychlorinated biphenyls, 2 polybrominated diphenyl ethers (PBDEs), 5 perfluoroalkyl substances (PFAS), 10 phthalate metabolites, 3 phenols, 4 parabens, and 4 organophosphate pesticide metabolites measured in urine and blood samples collected during pregnancy.Main Outcomes and MeasuresAt 6 to 11 years of age, a composite MetS risk score was constructed using z scores of waist circumference, systolic and diastolic blood pressures, triglycerides, high-density lipoprotein cholesterol, and insulin levels. Childhood levels of 44 urinary metabolites, 177 serum metabolites, and 35 plasma proteins were quantified using targeted methods. Associations were assessed using bayesian weighted quantile sum regressions applied to mixtures for each chemical group.ResultsThe study included 1134 mothers (mean [SD] age at birth, 30.7 [4.9] years) and their children (mean [SD] age, 7.8 [1.5] years; 617 male children [54.4%] and 517 female children [45.6%]; mean [SD] MetS risk score, −0.1 [2.3]). MetS score increased per 1-quartile increase of the mixture for metals (β = 0.44; 95% credible interval [CrI], 0.30 to 0.59), organochlorine pesticides (β = 0.22; 95% CrI, 0.15 to 0.29), PBDEs (β = 0.17; 95% CrI, 0.06 to 0.27), and PFAS (β = 0.19; 95% CrI, 0.14 to 0.24). High-molecular weight phthalate mixtures (β = −0.07; 95% CrI, −0.10 to −0.04) and low-molecular weight phthalate mixtures (β = −0.13; 95% CrI, −0.18 to −0.08) were associated with a decreased MetS score. Most EDC mixtures were associated with elevated proinflammatory proteins, amino acids, and altered glycerophospholipids, which in turn were associated with increased MetS score.Conclusions and RelevanceThis cohort study suggests that prenatal exposure to EDC mixtures may be associated with adverse metabolic health in children. Given the pervasive nature of EDCs and the increase in MetS, these findings hold substantial public health implications.

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Section: Discussionmentioning

confidence: 99%

“…BWQS characteristics are available in eAppendix 2 in Supplement 1. BWQS regressions were stratified by sex due to potential sex-specific effects of some EDCs . We note that sex interactions were not tested due to the absence of interaction testing functions in the BWQS package.…”

Section: Methodsmentioning

confidence: 99%

Prenatal Exposure to Chemical Mixtures and Metabolic Syndrome Risk in Children

Güil-Oumrait,

Stratakis,

Maitre

et al. 2024

JAMA Netw Open

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“…Recently, the discovery that PCBs can undergo hydroxylation through natural and anthropogenic means to form hydroxylated polychlorinated biphenyls (OH‐PCBs) has raised serious environmental concern because OH‐PCBs are known to be several orders of magnitude more toxic than the parent PCBs (Tehrani & Van Aken, 2014). Previous studies have shown that exposure of humans and animals to OH‐PCBs causes certain biological perturbations that are linked to the following downstream events and adverse outcomes: disruption of thyroid homeostasis, breast cancer, prolonged estrous cycle, decreased mental development index, low birth weight, alteration in steroid homeostasis, increased incidences of cervicovaginal track tumor, and increased levels of cardiometabolic risk factors (Berghuis et al, 2022; Dirinck et al, 2016; Kezios et al, 2017; Martinez et al, 2005; Meerts et al, 2004; Nomiyama et al, 2010; Park et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of Predictive Quantitative Structure–Activity Relationship Models for Estrogenic Activities of Hydroxylated Polychlorinated Biphenyls

Akinola

Uzairu

Shallangwa

et al. 2023

Enviro Toxic and Chemistry

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Disruption of the endocrine system by hydroxylated polychlorinated biphenyls (OH‐PCBs) is hypothesized, among other potential mechanisms, to be mediated via nuclear receptor binding. Due to the high cost and lengthy time required to produce high‐quality experimental data, empirical data to support the nuclear receptor binding hypothesis are in short supply. In the present study, two quantitative structure–activity relationship models were developed for predicting the estrogenic activities of OH‐PCBs. Findings revealed that model I (for the estrogen receptor α dataset) contained five two‐dimensional (2D) descriptors belonging to the classes autocorrelation, Burden modified eigenvalues, chi path, and atom type electrotopological state, whereas model II (for the estrogen receptor β dataset) contained three 2D and three 3D descriptors belonging to the classes autocorrelation, atom type electrotopological state, and Radial Distribution Function descriptors. The internal and external validation metrics reported for models I and II indicate that both models are robust, reliable, and suitable for predicting the estrogenic activities of untested OH‐PCB congeners. Environ Toxicol Chem 2023;42:823–834. © 2023 SETAC

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“…However, whether lower birth weight and lower thyroid levels are related to the development of overweight and obesity is unclear. In this Special Issue, Berghuis et al showed that higher levels of the contaminants, PCB, OH-PCB and PBDEs, in mothers were associated with metabolic cardiovascular risk markers for developing obesity and cardiovascular diseases in their offspring when measured during adolescence, especially in boys [8].…”

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confidence: 99%