Prenatal environmental tobacco smoke exposure alters children’s cognitive control circuitry: A preliminary study

Margolis, Amy; Pagliaccio, David; Ramphal, Bruce; Banker, Sarah; Thomas, Lauren; Robinson, Morgan; Honda, Masato; Sussman, Tamara J.; Posner, Jonathan; Kannan, Kurunthachalam; Herbstman, Julie B.; Rauh, Virginia; Marsh, Rachel

doi:10.1016/j.envint.2021.106516

Cited by 16 publications

(14 citation statements)

References 56 publications

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“…As described previously ( 59 ), we recruited N = 53 children of ages 7 years and older from the Sibling-Hermanos birth cohort at Columbia University for a neuroimaging visit (see Supplemental Methods ). Mothers were nonsmokers.…”

Section: Methodsmentioning

confidence: 99%

Prenatal Exposure to Air Pollution and Early-Life Stress Effects on Hippocampal Subregional Volumes and Associations With Visuospatial Reasoning

Margolis

Cohen

Ramphal

et al. 2022

Biological Psychiatry Global Open Science

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Section: Methodsmentioning

confidence: 99%

Prenatal Exposure to Air Pollution and Early-Life Stress Effects on Hippocampal Subregional Volumes and Associations With Visuospatial Reasoning

Margolis

Cohen

Ramphal

et al. 2022

Biological Psychiatry Global Open Science

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“…To evaluate the effects of ETS exposure, Margolis et al recruited from a prospective longitudinal urban birth cohort, selecting non-smoking mothers and their children ages 7-9 years [40]. Prenatal maternal and postnatal child urine samples were analyzed for cotinine concentrations.…”

Section: Ets Multimodal Mri Cognitive Control Circuitry In Urban Chil...mentioning

confidence: 99%

“…Post-hoc analyses of postnatal exposure were not associated with brain measures when prenatal exposure was included in the model. Margolis et al suggested that maternal ETS exposure during pregnancy posited deleterious effects on the structure and function of cognitive control circuitry which impacted attentional capacity in school-age children [40].…”

Section: Ets Multimodal Mri Cognitive Control Circuitry In Urban Chil...mentioning

confidence: 99%

Pediatric Exposures to Neurotoxicants: A Review of Magnetic Resonance Imaging and Spectroscopy Findings

Cecil

2022

Diagnostics

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Heavy metals, including lead and manganese, air pollution, pesticides, environmental tobacco smoke, and flame retardants are among the known and suspected environmental neurotoxicant exposures examined with magnetic resonance imaging (MRI)-based studies of pediatric populations. Many studies feature morphological changes associated with the exposures while others employ magnetic resonance spectroscopy, diffusion imaging, task-based, and resting state functional magnetic resonance imaging to reveal abnormal metabolic concentrations, white matter disorganization, and atypical patterns of activation. Some studies follow pregnant women and their offspring throughout the lifespan with collection of individual specimens as exposure biomarkers. Others innovatively make use of public databases to obtain relevant exposure biomarkers while taking advantage of these studies in their efforts to monitor developmental features in large, population-based, imaging cohorts. As exposures to neurotoxicants in the womb and throughout childhood have life-long impacts on health and well-being, the importance of these innovative neuroimaging investigations is ever increasing.

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“…This association was also found in a study with a cohort of 574 children born from mothers who used NRTs during pregnancy[ 141 ]. Additionally, children prenatally exposed to smoke exhibited alterations in cognitive control circuitry and exhibited attention dysfunctions[ 142 ]. When taken together, the data strongly support the conclusion that nicotine during the prenatal period is associated with cognitive deficits.…”

Section: Pne Effects On Cognitive-based Behaviors That Could Involve ...mentioning

confidence: 99%

Prenatal nicotine alters development of the laterodorsal tegmentum: Possible role for attention-deficit/hyperactivity disorder and drug dependence

Polli¹,

Kohlmeier²

2022

WJP

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As we cycle between the states of wakefulness and sleep, a bilateral cholinergic nucleus in the pontine brain stem, the laterodorsal tegmentum (LDT), plays a critical role in controlling salience processing, attention, behavioral arousal, and electrophysiological signatures of the sub- and microstates of sleep. Disorders involving abnormal alterations in behavioral and motivated states, such as drug dependence, likely involve dysfunctions in LDT signaling. In addition, as the LDT exhibits connectivity with the thalamus and mesocortical circuits, as well as receives direct, excitatory input from the prefrontal cortex, a role for the LDT in cognitive symptoms characterizing attention-deficit/hyperactivity disorder (ADHD) including impulsivity, inflexibility, and dysfunctions of attention is suggested. Prenatal nicotine exposure (PNE) is associated with a higher risk for later life development of drug dependence and ADHD, suggesting alteration in development of brain regions involved in these behaviors. PNE has been shown to alter glutamate and cholinergic signaling within the LDT. As glutamate and acetylcholine are major excitatory mediators, these alterations would likely alter excitatory output to target regions in limbic motivational circuits and to thalamic and cortical networks mediating executive control. Further, PNE alters neuronal development and transmission within prefrontal cortex and limbic areas that send input to the LDT, which would compound effects of differential processing within the PNE LDT. When taken together, alterations in signaling in the LDT are likely to play a role in negative behavioral outcomes seen in PNE individuals, including a heightened risk of drug dependence and ADHD behaviors.

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Prenatal environmental tobacco smoke exposure alters children’s cognitive control circuitry: A preliminary study

Cited by 16 publications

References 56 publications

Prenatal Exposure to Air Pollution and Early-Life Stress Effects on Hippocampal Subregional Volumes and Associations With Visuospatial Reasoning

Prenatal Exposure to Air Pollution and Early-Life Stress Effects on Hippocampal Subregional Volumes and Associations With Visuospatial Reasoning

Pediatric Exposures to Neurotoxicants: A Review of Magnetic Resonance Imaging and Spectroscopy Findings

Prenatal nicotine alters development of the laterodorsal tegmentum: Possible role for attention-deficit/hyperactivity disorder and drug dependence

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