Prenatal ethanol exposure and enkephalinergic neurotransmission

Méndez, Milagros; Hernández-Fonseca, Karla; Abate, Paula

doi:10.1016/bs.vh.2019.05.005

Cited by 2 publications

(4 citation statements)

References 95 publications

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“…All these receptors are associated with Gi proteins. Furthermore, opioid receptors were found to participate in pain perception between the brain and spinal cord [ 167 ]. Additionally, they were reported to mediate emotions and behaviours such as distress (emotional pain), anger, anxiety, sadness, motivation, and social affiliative actions [ 168 ].…”

Section: Endogenous Neuromodulators and Pharmacological Agents In Bra...mentioning

confidence: 99%

“…Endogenous opioids were described as being negative growth factors during brain maturation, and opioid receptor antagonist naltrexone administration during pregnancy was found to increase proliferation of brain cells and overall brain weight [ 180 ]. Moreover, the abuse of some addictive agents or drugs (ethanol, and cocaine) that have neurodevelopmental consequences was clearly associated with elevated opioid signalling in different areas of the developing brain [ 79 , 167 , 181 ]. Therefore, neurodevelopmental changes produced by the addictive drugs during pregnancy can partially be explained by an opioid receptor upregulation mechanistically influencing neuron maturation[ 182 ].…”

Section: Endogenous Neuromodulators and Pharmacological Agents In Bra...mentioning

confidence: 99%

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Role of Brain Modulators in Neurodevelopment: Focus on Autism Spectrum Disorder and Associated Comorbidities

et al. 2022

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Autism spectrum disorder (ASD) and associated neurodevelopmental disorders share similar pathogenesis and clinical features. Pathophysiological changes in these diseases are rooted in early neuronal stem cells in the uterus. Several genetic and environmental factors potentially perturb neurogenesis and synaptogenesis processes causing incomplete or altered maturation of the brain that precedes the symptomology later in life. In this review, the impact of several endogenous neuromodulators and pharmacological agents on the foetus during pregnancy, manifested on numerous aspects of neurodevelopment is discussed. Within this context, some possible insults that may alter these modulators and therefore alter their role in neurodevelopment are high-lighted. Sometimes, a particular insult could influence several neuromodulator systems as is supported by recent research in the field of ASD and associated disorders. Dopaminergic hy-pothesis prevailed on the table for discussion of the pathogenesis of schizophrenia (SCH), atten-tion-deficit hyperactivity disorder (ADHD) and ASD for a long time. However, recent cumulative evidence suggests otherwise. Indeed, the neuromodulators that are dysregulated in ASD and comorbid disorders are as diverse as the causes and symptoms of this disease. Additionally, these neuromodulators have roles in brain development, further complicating their involvement in comorbidity. This review will survey the current understanding of the neuromodulating systems to serve the pharmacological field during pregnancy and to minimize drug-related insults in pa-tients with ASD and associated comorbidity disorders, e.g., SCH or ADHD.

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Section: Endogenous Neuromodulators and Pharmacological Agents In Bra...mentioning

confidence: 99%

Section: Endogenous Neuromodulators and Pharmacological Agents In Bra...mentioning

confidence: 99%

Role of Brain Modulators in Neurodevelopment: Focus on Autism Spectrum Disorder and Associated Comorbidities

et al. 2022

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show abstract

“…The endogenous opioid system plays a significant role in reward and reinforcement (Méndez, Hernández-Fonseca, & Abate, 2019). There are three distinct families of endogenous opioid system defined by their precursor molecules: pro-opiomelanocortin is the precursor for β-endorphins, pro-enkephalins for met-enkephalins, and prodynorphins gives rise to dynorphins.…”

Section: Prenatal Alcohol Consumption: Mechanisms To Aldmentioning

confidence: 99%

“…The μ and δ-opioid systems are involved in ethanol acceptance in adulthood (Méndez et al, 2019); the κ-opioid system causes the aversive effects of alcohol in older infants and adults (Pautassi, Nizhnikov, Spear, & Molina, 2012). However, in early postnatal life, the κ-opioid system confers an appetitive impact (Barr, Wang, & Carden, 1994).…”

Section: Prenatal Alcohol Consumption: Mechanisms To Aldmentioning

confidence: 99%

Early‐lifeexposure to alcohol and the risk ofalcohol‐inducedliver disease in adulthood

Asiedu

Nyakudya

Lembede

et al. 2021

Birth Defects Research

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Alcohol consumption remains prevalent among pregnant and nursing mothers despite the well‐documented adverse effects this may have on the offspring. Moderate‐to‐high levels of alcohol consumption in pregnancy result in fetal alcohol syndrome (FAS) disorders, with brain defects being chief among the abnormalities. Recent findings indicate that while light‐to‐moderate levels may not cause FAS, it may contribute to epigenetic changes that make the offspring prone to adverse health outcomes including metabolic disorders and an increased propensity in the adolescent‐onset of drinking alcohol. On the one hand, prenatal alcohol exposure (PAE) causes epigenetic changes that affect lipid and glucose transcript regulating genes resulting in metabolic abnormalities. On the other hand, it can program offspring for increased alcohol intake, enhance its palatability, and increase acceptance of alcohol's flavor through associative learning, making alcohol a plausible second hit for the development of alcohol‐induced liver disease. Adolescent drinking results in alcohol dependence and abuse in adulthood. Adolescent drinking results in alcohol dependence and abuse in adulthood. Alterations on the opioid system, particularly, the mu‐opioid system, has been implicated in the mechanism that induces increased alcohol consumption and acceptance. This review proposes a mechanism that links PAE to the development of alcoholism and eventually to alcoholic liver disease (ALD), which results from prolonged alcohol consumption. While PAE may not lead to ALD development in childhood, there are chances that it may lead to ALD in adulthood.

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Prenatal ethanol exposure and enkephalinergic neurotransmission

Cited by 2 publications

References 95 publications

Role of Brain Modulators in Neurodevelopment: Focus on Autism Spectrum Disorder and Associated Comorbidities

Role of Brain Modulators in Neurodevelopment: Focus on Autism Spectrum Disorder and Associated Comorbidities

Early‐lifeexposure to alcohol and the risk ofalcohol‐inducedliver disease in adulthood

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