Prenatal exposure of staphylococcal enterotoxin B attenuates the development and function of blood regulatory T cells to repeated staphylococcal enterotoxin B exposure in adult offspring rats

Gao, Shanjun; Sun, Jing; Li, Huihui; Chen, Jie; Kashif, Mohsin Raza; Zhou, Ping; Li, Wei; Zheng, Qingwei; Wu, Ligao; Guan, Jun-Chang

doi:10.1099/jmm.0.001152

Cited by 3 publications

(1 citation statement)

References 38 publications

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“…Recently, Jacobs proposed that long-COVID could be due in part to SARS-CoV-2 superantigen-mediated immune suppression, leading to persistent systemic SARS-CoV-2 infection [98]. In terms of pregnancy, prenatal exposure of rats to SEB was shown to attenuate the development and function of regulatory T cells in adult offspring [103] and alter the behaviour (i.e., increased anxiety and locomotion) of mice offspring [104].…”

Section: The Sars-cov-2 Spike Protein Triggers Autoimmune Responsesmentioning

confidence: 99%

Maternal COVID-19 Vaccination and Its Potential Impact on Fetal and Neonatal Development

et al. 2021

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Vaccines have been developed at “warp speed” to combat the COVID-19 pandemic caused by the SARS-CoV-2 coronavirus. Although they are considered the best approach for preventing mortality, when assessing the safety of these vaccines, pregnant women have not been included in clinical trials. Thus, vaccine safety for this demographic, as well as for the developing fetus and neonate, remains to be determined. A global effort has been underway to encourage pregnant women to get vaccinated despite the uncertain risk posed to them and their offspring. Given this, post-hoc data collection, potentially for years, will be required to determine the outcomes of COVID-19 and vaccination on the next generation. Most COVID-19 vaccine reactions include injection site erythema, pain, swelling, fatigue, headache, fever and lymphadenopathy, which may be sufficient to affect fetal/neonatal development. In this review, we have explored components of the first-generation viral vector and mRNA COVID-19 vaccines that are believed to contribute to adverse reactions and which may negatively impact fetal and neonatal development. We have followed this with a discussion of the potential for using an ovine model to explore the long-term outcomes of COVID-19 vaccination during the prenatal and neonatal periods.

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Section: The Sars-cov-2 Spike Protein Triggers Autoimmune Responsesmentioning

confidence: 99%

Maternal COVID-19 Vaccination and Its Potential Impact on Fetal and Neonatal Development

et al. 2021

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Booster immunization improves the generation of T follicular helper (Tfh) cells specific to hepatitis B surface antigen (HBsAg) after prenatal HBsAg exposure

Wang

Chen

Wang

et al. 2021

Vaccine

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The significance of long chain non-coding RNA signature genes in the diagnosis and management of sepsis patients, and the development of a prediction model

Bai,

Gao,

Yan

et al. 2024

Front. Immunol.

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BackgroundSepsis is a life-threatening organ dysfunction condition produced by dysregulation of the host response to infection. It is now characterized by a high clinical morbidity and mortality rate, endangering patients’ lives and health. The purpose of this study was to determine the value of Long chain non-coding RNA (LncRNA) RP3_508I15.21, RP11_295G20.2, and LDLRAD4_AS1 in the diagnosis of adult sepsis patients and to develop a Nomogram prediction model.MethodsWe screened adult sepsis microarray datasets GSE57065 and GSE95233 from the GEO database and performed differentially expressed genes (DEGs), weighted gene co-expression network analysis (WGCNA), and machine learning methods to find the genes by random forest (Random Forest), least absolute shrinkage and selection operator (LASSO), and support vector machine (SVM), respectively, with GSE95233 as the training set and GSE57065 as the validation set. Differentially expressed genes (DEGs), weighted gene co-expression network analysis (WGCNA), boxplot statistical analysis, and ROC analysis by Random Forest, Least Absolute Shrinkage and Selection Operator (LASSO), and Support Vector Machine (SVM) machine learning methods were used to identify characteristic genes and build the Nomogram Prediction model.ResultsGSE95233 yielded a total of 1069 genes, 102 of which were sepsis-related and 22 of which were non-sepsis controls. GSE57065 yielded a total of 899 genes, with 467 up-regulated and 432 down-regulated, including 82 sepsis-related genes and 25 non-sepsis control genes. WGCNA analysis excluded outlier samples, leaving 2,029 genes for relationship analysis between sepsis- and non-sepsis patient-associated LncRNA network representation modules, as well as Wein plots of differential genes versus genes in key modules of weighted co-expression network analysis to analyze gene intersections. Machine Learning found the sepsis-related characteristic LncRNAs RP3-508I15.21, RP11-295G20.2, LDLRAD4-AS1, and CTD-2542L18.1. The datasets GSE95233 and GSE57065 were analyzed using Boxplot against the screened genes listed above, respectively. The p-value between the sepsis and non-sepsis groups was less than 0.05, indicating that anomalies were statistically significant. CTD-2542L18.1 in dataset GSE57065 had an AUC value of 0.638, which was less than 0.7 and did not indicate diagnostic significance, but RP3-508I15.21, RP11-295G20.2, and LDLRAD4-AS1 had AUC values more than 0.7 after ROC analysis. All four sepsis-associated LncRNA ROC analyses in dataset GSE95233 exhibited AUC values more than 0.7, indicating diagnostic significance.ConclusionLncRNAs RP3_508I15.21, RP11_295G20.2, and LDLRAD4_AS1 have some utility in the diagnosis and treatment of adult sepsis patients, as well as some reference importance in guiding the diagnosis and treatment of clinical sepsis.

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Prenatal exposure of staphylococcal enterotoxin B attenuates the development and function of blood regulatory T cells to repeated staphylococcal enterotoxin B exposure in adult offspring rats

Cited by 3 publications

References 38 publications

Maternal COVID-19 Vaccination and Its Potential Impact on Fetal and Neonatal Development

Maternal COVID-19 Vaccination and Its Potential Impact on Fetal and Neonatal Development

Booster immunization improves the generation of T follicular helper (Tfh) cells specific to hepatitis B surface antigen (HBsAg) after prenatal HBsAg exposure

The significance of long chain non-coding RNA signature genes in the diagnosis and management of sepsis patients, and the development of a prediction model

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