Prenatal exposure to acid‐suppressive drugs and the risk of childhood asthma: a population‐based <scp>D</scp>anish cohort study

Andersen, Ane Birgitte Telén; Erichsen, Rune; Farkas, Dóra Körmendiné; Mehnert, Frank; Ehrenstein, Véra; Sørensen, Henrik Toft

doi:10.1111/j.1365-2036.2012.05073.x

Cited by 39 publications

(43 citation statements)

References 41 publications

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“…Gastric acid suppression may predispose patients to develop food allergy [90]. Acid inhibiting medication during pregnancy was reported to increase the risk to develop asthma in the offspring [90,91].…”

Section: Therapeutic Optionsmentioning

confidence: 98%

An updated review on gastro-esophageal reflux in pediatrics

Vandenplas¹,

Hauser

2015

Expert Review of Gastroenterology & Hepatology

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Comprehensive guidelines for the diagnosis and management of gastro-esophageal reflux (GER) and GER disease (GERD) were developed by the European and North American Societies for Pediatric Gastroenterology, Hepatology and Nutrition. GERD is reflux associated with troublesome symptoms or complications. The recognition of GER and GERD is relevant to implement best management practices. A conservative management is indicated in infants with uncomplicated physiologic reflux. Children with GERD may benefit from further evaluation and treatment. Since the publications of the European and North American Societies for Pediatric Gastroenterology, Hepatology and Nutrition guidelines in 2009, no important novelties in drug treatment have been reported. Innovations are mainly restricted to the management of regurgitation in infants. During the last 5 years, pros and cons of multichannel intraluminal impedance have been highlighted. However, overall 'not much has changed' in the diagnosis and management of GER and GERD in infants and children.

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Section: Therapeutic Optionsmentioning

confidence: 98%

An updated review on gastro-esophageal reflux in pediatrics

Vandenplas¹,

Hauser

2015

Expert Review of Gastroenterology & Hepatology

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“…Gastric acid suppression predisposes patients to develop food allergy [173][174][175]. Antiacid medication during pregnancy was reported to increase the risk to develop asthma in the offspring [176].…”

Section: H²-receptor Antagonists and Proton Pump Inhibitorsmentioning

confidence: 99%

Gastroesophageal Reflux

Vandenplas¹

2015

Textbook of Pediatric Gastroenterology, Hepatology and Nutrition

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“…Examples include exposure to house dust mites and dampness [93,94], older siblings and number of siblings [95,96], pollen [97], paracetamol, both prenatally and in adulthood [98,99], maternal acid-suppressive medication during pregnancy [100] and birth by cesarean section [101,102]. The evidence linking vitamin D levels to risk of allergic disease is conflicting [103,104], but if a correlation does exist it could potentially be epigenetically mediated.…”

Section: Dna Methylation and Allergic Diseasementioning

confidence: 99%

Epigenomics and Allergic Disease

et al. 2013

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Allergic disease development is affected by both genes and the environment, and epigenetic mechanisms are hypothesized to mediate these environmental effects. In this article, we discuss the link between the environment, DNA methylation and allergic disease, as well as questions of causality inherent to analyses of DNA methylation. From the practical side, we describe characteristics of allergic phenotypes and contrast different epidemiologic study designs used in epigenetic research. We examine methodological considerations, how best to conduct preprocessing and analysis of DNA methylation data sets, and the latest methods, technologies and discoveries in this rapidly advancing field. DNA methylation and other epigenetic marks are firmly entwined with allergic disease, a link that may hold the basis for future allergic disease diagnosis and treatment.

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Prenatal exposure to acid‐suppressive drugs and the risk of childhood asthma: a population‐based Danish cohort study

Abstract: SUMMARY BackgroundProton pump inhibitors (PPIs) may activate the immune system and cause asthma.

Cited by 39 publications

References 41 publications

An updated review on gastro-esophageal reflux in pediatrics

An updated review on gastro-esophageal reflux in pediatrics

Gastroesophageal Reflux

Epigenomics and Allergic Disease

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