Prenatal exposure to ambient air pollutants and congenital heart defects: An umbrella review

Michel, Sophie; Atmakuri, Aishwarya; Ehrenstein, Ondine S. von

doi:10.1016/j.envint.2023.108076

Cited by 5 publications

(3 citation statements)

References 123 publications

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“…It is worth noting that although embryonic mortality occurred after ZnO NPs treatment, there was no statistically significant difference in mortality rate between ZnO NPs treatment group and control group, which indicated that the negative impact of ZnO NPs exposure on embryonic development mainly manifests as teratogenicity rather than lethality under the experimental conditions of this study. The above result is consistent with the findings of previous studies, which have confirmed the strong association between environmental exposure to nanoparticles during pregnancy and adverse pregnancy outcomes, including low birth weight and preterm birth (Dadvand et al 2013 ; Pedersen et al 2013 ), risks of adverse pregnancy (Gómez-Roig et al 2021 ; Yu et al 2022 ), cardiovascular disease (Kim et al 2020 ; Michel et al 2023 ), respiratory problems (Bharadwaj et al 2016 ; Hehua et al 2017 ) and neurodevelopmental changes (Lertxundi et al 2019 ; Song et al 2021 ; Sunyer and Dadvand 2019 ). In addition, studies have confirmed that compared with the peri-implantation period of pregnancy, maternal mice in the organogenesis period are more susceptible to the effects of ZnO NPs, potentially leading to embryotoxicity (Teng et al 2020 ).…”

Section: Discussionsupporting

confidence: 91%

Zinc oxide nanoparticles induces cell death and consequently leading to incomplete neural tube closure through oxidative stress during embryogenesis

Yan,

Huang,

et al. 2024

Cell Biol Toxicol

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The implementation of Zinc oxide nanoparticles (ZnO NPs) raises concerns regarding their potential toxic effects on human health. Although more and more researches have confirmed the toxic effects of ZnO NPs, limited attention has been given to their impact on the early embryonic nervous system. This study aimed to explore the impact of exposure to ZnO NPs on early neurogenesis and explore its underlying mechanisms. We conducted experiments here to confirm the hypothesis that exposure to ZnO NPs causes neural tube defects in early embryonic development. We first used mouse and chicken embryos to confirm that ZnO NPs and the Zn2+ they release are able to penetrate the placental barrier, influence fetal growth and result in incomplete neural tube closure. Using SH-SY5Y cells, we determined that ZnO NPs-induced incomplete neural tube closure was caused by activation of various cell death modes, including ferroptosis, apoptosis and autophagy. Moreover, dissolved Zn2+ played a role in triggering widespread cell death. ZnO NPs were accumulated within mitochondria after entering cells, damaging mitochondrial function and resulting in the over production of reactive oxygen species, ultimately inducing cellular oxidative stress. The N-acetylcysteine (NAC) exhibits significant efficacy in mitigating cellular oxidative stress, thereby alleviating the cytotoxicity and neurotoxicity brought about by ZnO NPs. These findings indicated that the exposure of ZnO NPs in early embryonic development can induce cell death through oxidative stress, resulting in a reduced number of cells involved in early neural tube closure and ultimately resulting in incomplete neural tube closure during embryo development. The findings of this study could raise public awareness regarding the potential risks associated with the exposure and use of ZnO NPs in early pregnancy. Graphical Abstract

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Section: Discussionsupporting

confidence: 91%

Zinc oxide nanoparticles induces cell death and consequently leading to incomplete neural tube closure through oxidative stress during embryogenesis

Yan,

Huang,

et al. 2024

Cell Biol Toxicol

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“…It is interesting to note that others have evaluated systematic reviews of environmental health studies (notably on air pollution and reproductive and child health) from a methodological point of view. 12 After examining no less than 177 systematic reviews, the authors found that only 18 of these used some kind of evidence grading system. A wide variety of approaches and systems was identified, effectively making it impossible to draw firm conclusions about these methods' validity and results.…”

Section: Reviewing Umbrella Reviews Of Systematic Reviews Of Original...mentioning

confidence: 99%

Reviewing umbrella reviews of systematic reviews of original studies on the effects of air pollution on disease

Brunekreef,

Straif,

Pearce

2024

Environmental Epidemiology

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“…Methodological weaknesses specific to assessing evidence related to environment exposures [ 40 , 41 ], and specifically ambient air pollution [ 42 ], and pregnancy outcomes [ 43 , 44 ], were previously identified among systematic reviews, particularly related to assessing internal validity and a lack of transparent evidence grading methodologies. Because systematic review methodologies were primarily developed for clinical trials, their suitability for evaluating evidence from observational/ environmental health, and how these methods can best be adapted, has been debated [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Systems for rating bodies of evidence used in systematic reviews of air pollution exposure and reproductive and children’s health: a methodological survey

Michel,

Atmakuri,

von Ehrenstein

2024

Environ Health

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Background Translating findings from systematic reviews assessing associations between environmental exposures and reproductive and children’s health into policy recommendations requires valid and transparent evidence grading. Methods We aimed to evaluate systems for grading bodies of evidence used in systematic reviews of environmental exposures and reproductive/ children’s health outcomes, by conducting a methodological survey of air pollution research, comprising a comprehensive search for and assessment of all relevant systematic reviews. To evaluate the frameworks used for rating the internal validity of primary studies and for grading bodies of evidence (multiple studies), we considered whether and how specific criteria or domains were operationalized to address reproductive/children’s environmental health, e.g., whether the timing of exposure assessment was evaluated with regard to vulnerable developmental stages. Results Eighteen out of 177 (9.8%) systematic reviews used formal systems for rating the body of evidence; 15 distinct internal validity assessment tools for primary studies, and nine different grading systems for bodies of evidence were used, with multiple modifications applied to the cited approaches. The Newcastle Ottawa Scale (NOS) and the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) framework, neither developed specifically for this field, were the most commonly used approaches for rating individual studies and bodies of evidence, respectively. Overall, the identified approaches were highly heterogeneous in both their comprehensiveness and their applicability to reproductive/children’s environmental health research. Conclusion Establishing the wider use of more appropriate evidence grading methods is instrumental both for strengthening systematic review methodologies, and for the effective development and implementation of environmental public health policies, particularly for protecting pregnant persons and children.

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Prenatal exposure to ambient air pollutants and congenital heart defects: An umbrella review

Cited by 5 publications

References 123 publications

Zinc oxide nanoparticles induces cell death and consequently leading to incomplete neural tube closure through oxidative stress during embryogenesis

Zinc oxide nanoparticles induces cell death and consequently leading to incomplete neural tube closure through oxidative stress during embryogenesis

Reviewing umbrella reviews of systematic reviews of original studies on the effects of air pollution on disease

Systems for rating bodies of evidence used in systematic reviews of air pollution exposure and reproductive and children’s health: a methodological survey

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